No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Citicoline 250 mg Ingredients & Drug Interactions

by AN Amazing Nutrition Amazing Formulas

Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Citicoline 250 mg is a dietary supplement by AN Amazing Nutrition Amazing Formulas with 1 active ingredient. Its ingredients are commonly taken for memory and thinking, brain health and aging, stroke recovery support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: citicoline, a compound your body naturally makes that plays a role in brain cell function and signaling. The capsule also contains inactive ingredients — gelatin, rice flour, silicon dioxide, and vegetable magnesium stearate — which help form and preserve the supplement.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain health, memory, concentration and cognitive function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cerebrovascular disease, Stroke, Traumatic brain injury (TBI) — and 4 related terms.
  • The strongest evidence on file: Citicoline is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Citicoline is rated "Possibly Ineffective" for Stroke.
  • Also on file: Citicoline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cerebrovascular disease, Vascular dementia, and more.

The evidence for citicoline is mixed. For age-related cognitive decline and glaucoma, the research suggests it's possibly effective — meaning there's some promising data, but it's not yet ironclad.

For stroke, the evidence currently points toward it being possibly ineffective. For Alzheimer disease, traumatic brain injury, and cardiac arrest, we don't yet have enough reliable evidence to say whether it works.

The evidence, ingredient by ingredient Citicoline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Citicoline is generally well tolerated in studies, though long-term safety isn't fully established. The side effects seen in trials were mild — a small number of patients reported abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, insomnia, nausea, or rash.

There isn't enough safety data to know whether it's safe during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Citicoline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for citicoline. That said, talk with your pharmacist about your specific medications — they can spot anything we might have missed and give you personalized advice.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Citicoline might be worth considering if you're interested in brain health and age-related cognitive support, since some research suggests it may help with those areas. If you're pregnant, breastfeeding, or taking any medications, check with your doctor or pharmacist first to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Citicoline 250 mg, straight from the product label.

Brand AN Amazing Nutrition Amazing Formulas
Barcode (UPC) 819209024027
Net contents 240 Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255851
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
240
UPC/BARCODE
819209024027
IngredientAmount% DV
Citicoline250 mg--

Other ingredients: Gelatin, Rice Flour, Silicon Dioxide, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We believe that Amazing Nutrition is the key for healthy living. We are passionate about bringing you the finest selection of products which can perfectly complement a healthy diet and active lifestyle.

Shop online at: amazingnutrition.com Call toll-free: 1-800-526-0177 Vitamin angels Proud supporter

Formula

Amazing Formulas Citicoline supplement supports overall brain health by increasing blood oxygen levels and enhancing glucose intake in the brain. This allows the brain to enhance memory, concentration, learning capabilities, cognitive functions and mental clarity. Citicoline may also help to reduce the feelings of stress.

FDA Statement of Identity

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Dietary Supplement

Precautions

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Caution: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store in a cool, dry place.

Formulation

Amazing Nutrition an FDA regulated facility

Promotes brain health Supports memory, focus & mental clarity Supports learning & cognitive functions

Contains No: Preservatives, artificial colors, flavors or sweeteners, sugar, starch, milk, lactose, gluten, wheat, yeast, fish or sodium.

Seals/Symbols

Made In USA GMP Good Manufacturing Practice Quality Product

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) capsule daily, preferably with a meal or as directed by a health care professional.

See for yourself

Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.

Citicoline

No known
interactions
250 mg per serving

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

Citicoline monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Silicon Dioxide, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Citicoline 250 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Citicoline 250 mg, from the product label.

AN Amazing Nutrition Amazing Formulas

See all AN Amazing Nutrition Amazing Formulas products
Name
Amazing Nutrition
City
Jersey City
State
NJ
ZipCode
07310
Phone Number
1-800-526-0177
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas: Common Questions

Does Citicoline 250 mg by AN Amazing Nutrition Amazing Formulas interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Citicoline 250 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Citicoline 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is citicoline and what's it supposed to do?
Citicoline is a compound your body produces naturally that supports brain cell structure and function. This supplement is used to address age-related cognitive decline and glaucoma, among other conditions.
Is citicoline safe to take while pregnant or breastfeeding?
There isn't enough safety data to know either way. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.
What side effects might I experience?
Citicoline is generally well tolerated, but some people in studies reported mild side effects like headache, insomnia, nausea, back pain, abdominal pain, constipation, diarrhea, blurred vision, swelling, or rash. Most were uncommon.
Does citicoline help with Alzheimer disease or stroke recovery?
For Alzheimer disease, we don't have enough reliable evidence yet to say. For stroke, the current evidence suggests it's probably not effective.
How long-term safe is citicoline?
Studies show it's generally well tolerated in the short term, but long-term safety isn't fully established. If you plan to take it regularly, talk with your doctor or pharmacist about what we do and don't know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Citicoline 250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Citicoline 250 mg label
Go deeper

The Full Monographs Behind Citicoline 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Citicoline 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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