No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Cytidine Choline 250 mg Ingredients & Drug Interactions

by Cardiovascular Research

Cytidine Choline 250 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cytidine Choline 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Cytidine Choline 250 mg is a dietary supplement by Cardiovascular Research with 1 active ingredient. Its ingredients are commonly taken for memory and thinking, brain health and aging, stroke recovery support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Cytidine Choline 250 mg by Cardiovascular Research

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cytidine diphosphate choline (citicoline), 250 mg per capsule. Citicoline is a compound your brain naturally makes and uses for cell membrane repair and communication.

The capsule itself is made from gelatin, and the inactive ingredients are magnesium stearate and silicon dioxide — standard fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain health and cognitive function support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cerebrovascular disease, Stroke, Traumatic brain injury (TBI), Vascular dementia — and 4 related terms.
  • The strongest evidence on file: Citicoline is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Citicoline is rated "Possibly Ineffective" for Stroke.
  • Also on file: Citicoline is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cerebrovascular disease, Vascular dementia, and more.

The evidence for citicoline is mixed and depends on the condition. It's rated possibly effective for age-related cognitive decline and glaucoma — meaning some evidence supports it, but more research would help confirm that.

For stroke, the evidence suggests it probably doesn't work. For Alzheimer disease, traumatic brain injury, and cardiac arrest, we don't have enough reliable evidence to say one way or the other.

The evidence, ingredient by ingredient Citicoline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Citicoline is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects reported when taken by mouth are abdominal pain, back pain, blurred vision, constipation, diarrhea, swelling, headache, trouble sleeping, nausea, and rash — but these occurred in a small number of trial participants.

The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

Side effects, ingredient by ingredient Citicoline

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That said, run your current medications through the checker on this page or ask your own doctor or pharmacist for peace of mind.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

If you're thinking about citicoline for age-related memory changes or eye health, the evidence is promising enough to discuss with your doctor. The ingredient is generally well tolerated, but long-term safety data is limited.

Avoid it if you're pregnant or breastfeeding unless your own doctor or pharmacist says otherwise. Check your exact medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cytidine Choline 250 mg, straight from the product label.

Brand Cardiovascular Research
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2013
DSLD ID 22378
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cytidine Choline 250 mg by Cardiovascular Research, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
IngredientAmount% DV
Cytidine Diphosphate Choline250 mg--

Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This product has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

General Statements

11030591 EXP0314

CYTIDINE CHOLINE (CDP-CHOLINE) is a scientifically-designed supplement and precursor to phospholipids. CPD-Choline is absorbed to multilamellar liposomes from lecithin for maximal absorption.

Seals/Symbols

ECOLOGICAL FORMULAS

FDA Statement of Identity

Dietary Supplement

A DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS Take one or two capsules daily, or as directed by a physician.

Formula

(CDP-Choline)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cytidine Choline 250 mg by Cardiovascular Research label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cytidine Choline 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cytidine Choline 250 mg by Cardiovascular Research

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Cytidine Diphosphate Choline

No known
interactions
250 mg per serving

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

Cytidine Diphosphate Choline monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cytidine Choline 250 mg by Cardiovascular Research Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Cytidine Choline 250 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Cytidine Choline 250 mg, from the product label.

Cardiovascular Research

See all Cardiovascular Research products
Name
CARDIOVASCULAR RESEARCH, LTD.
City
CONCORD
State
CA
ZipCode
94518
Pharmacist Counseling Corner

Cytidine Choline 250 mg by Cardiovascular Research: Common Questions

Does Cytidine Choline 250 mg by Cardiovascular Research interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Cytidine Choline 250 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Cytidine Choline 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data advises against it during pregnancy and breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about whether it's right for your situation.
What exactly is citicoline?
Citicoline is a compound your brain naturally makes and uses to build and repair cell membranes and help brain cells communicate. This supplement provides an extra source of it.
Does it really help with memory and thinking as I age?
The evidence is promising — it's rated possibly effective for age-related cognitive decline — but the science isn't settled yet. Some studies support it, but more research would help confirm that.
What side effects should I watch for?
The most common ones reported are abdominal pain, back pain, blurred vision, constipation, diarrhea, headache, trouble sleeping, nausea, and rash. These occurred in a small number of people in trials. Stop and call your doctor if anything bothers you.
Is this safe to take long-term?
Citicoline is generally well tolerated in short-term studies, but long-term safety isn't fully established. That's worth discussing with your doctor if you're planning to take it for months or longer.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cytidine Choline 250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cytidine Choline 250 mg label
Go deeper

The Full Monographs Behind Cytidine Choline 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...

Read the full Citicoline monograph →
Sources

Sources & How We Checked

Cytidine Choline 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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