Daily Essential Enzymes 500 mg Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking Daily Essential Enzymes 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Daily Essential Enzymes 500 mg is a dietary supplement by Source Naturals with 8 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Daily Essential Enzymes 500 mg by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has 8 active ingredients — all digestive enzymes that work to break down different components of food. Lipase breaks down fats, lactase breaks down milk sugar, and proteolytic enzymes (proteases) break down protein.
The formula also includes cellulase, hemicellulase, amyloglucosidase, alpha-amylase (which break down fiber and carbohydrates), and a vegetal analog of pancreatin. The remaining ingredients are inactive — cellulose, calcium sulfate, stearic acid, colloidal silicon dioxide, and magnesium stearate — which serve as fillers and binders in the capsule.
Does it work?
Strong evidence
Lactase in this formula is effective for lactose intolerance — if you have trouble digesting milk sugar, this ingredient has solid evidence behind it. For the other enzymes — lipase, proteases, and the carbohydrate-digesting enzymes — the evidence we hold rates them as insufficient to reliably say they work for dyspepsia, inflammatory bowel disease, or other digestive complaints.
That doesn't mean they don't help, only that the data supporting them isn't established in what we have on file.
How safe is it?
Well-documented data
Lipase and lactase are generally well tolerated when used as directed. Proteolytic enzymes (proteases) are also generally well tolerated for most adults, though they can occasionally cause digestive upset or allergic reactions — rare cases of occupational exposure to airborne protease have triggered allergic rhinoconjunctivitis or asthma, but that's not a typical concern with oral supplements.
If you have a serious digestive condition, check with your doctor before starting, as your situation may need medical guidance. For pregnancy, there isn't enough data to know whether lipase is safe — talk it over with your doctor.
Lactase is likely safe in pregnancy. Proteases are best avoided in pregnancy unless your doctor prescribes them.
For breastfeeding, lactase is likely safe, but lipase and proteases have limited data — ask your doctor or pharmacist before using regularly.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Digestive enzymes work locally in your gut rather than entering the bloodstream significantly, so medication interactions are uncommon — but if you take any medications or supplements, it's worth a quick check with your pharmacist to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
This is a broad-spectrum digestive enzyme blend — most useful if you have lactose intolerance, where lactase has proven effective. For other digestive complaints, the evidence is unclear.
The formula is generally well tolerated, with no documented interactions with medications for the ingredients we could check. If you have a serious digestive condition or are pregnant or breastfeeding, talk with your doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Daily Essential Enzymes 500 mg, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078013020 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 295695 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Daily Essential Enzymes 500 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lipase | 125 mg | -- |
| Lactase | 5 mg | -- |
| Cellulase | 5 mg | -- |
| Hemicellulase | 3 mg | -- |
| Amyloglucosidase | 12 mg | -- |
| Alpha-Amylase | 52 mg | -- |
| acid stable Protease | 12 mg | -- |
| To Break Down Protein | 0 NP | -- |
| To Break Down Fats | 0 NP | -- |
| To Break Down Carbohydrates | 0 NP | -- |
| To Break Down Fiber | 0 NP | -- |
| To Break Down Milk Sugar | 0 NP | -- |
| Vegetal Analog of Pancreatin | 286 mg | -- |
Other ingredients: Cellulose, Calcium Sulfate Anhydrous, Stearic Acid, Silicon Dioxide, Colloidal, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
FCC (Food Chemical Codex) units measure enzyme activity.
Formulation
Vegetarian
Bio Align
Digestive aid
Suitable for vegetarians and hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat.
Suitable for vegetarians and hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat.
Suitable for vegetarians and hypoallergenic: contains no yeast, dairy, egg, gluten, corn, soy or wheat. Contains no sugar, starch, salt, preservatives or artificial color, flavor or fragrance.
FDA Statement of Identity
Enzyme Supplement
Formula
Daily Essential Enzymes in vegetarian capsules
Each vegetarian capsule contains 500 mg of an all-vegetarian, broad spectrum blend of digestive enzymes.
Suggested/Recommended/Usage/Directions
Directions: 1 capsule with water at the beginning of each meal (or open capsule and sprinkle over food). If the meal is very large or unusually high in fat or protein, a second capsule can be taken. Do not sprinkle on hot food.
Storage
Store in a cool, dry place.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Copyright Source Naturals, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Daily Essential Enzymes 500 mg by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Daily Essential Enzymes 500 mg by Source Naturals
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
To Break Down Protein
- › Acid stable Protease
- › Vegetal Analog of Pancreatin
To Break Down Fats
- › Lipase
To Break Down Carbohydrates
- › Amyloglucosidase
- › Alpha-Amylase
To Break Down Fiber
- › Cellulase
- › Hemicellulase
To Break Down Milk Sugar
- › Lactase
Other (inactive) ingredients: Cellulose, Calcium Sulfate Anhydrous, Stearic Acid, Silicon Dioxide, Colloidal, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Daily Essential Enzymes 500 mg by Source Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Daily Essential Enzymes 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Daily Essential Enzymes 500 mg, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
Daily Essential Enzymes 500 mg by Source Naturals: Common Questions
Does Daily Essential Enzymes 500 mg by Source Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help with lactose intolerance?
Is this safe if I have IBS or another digestive condition?
Can I take this while pregnant?
What's a proteolytic enzyme?
Are there any side effects I should watch for?
Can I take this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Daily Essential Enzymes 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Daily Essential Enzymes 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph →Sources & How We Checked
Daily Essential Enzymes 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC