Digestive Enzymes Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Digestive Enzymes is a dietary supplement by California Gold Nutrition with 15 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Digestive Enzymes by California Gold Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 15 active digestive enzymes designed to support different stages of food breakdown in your digestive tract. Lipase breaks down fats, lactase helps digest milk sugar (lactose), and acid protease works in your stomach to break down proteins.
The remaining ingredients — including cellulase, amylase, phytase, and others — help break down carbohydrates, fiber, and other food components so your gut can absorb them more easily. The capsules also contain a few inactive ingredients: modified cellulose (for the capsule shell), rice bran, and medium-chain triglycerides powder.
There are no fillers or binders beyond what you see here.
Does it work?
Strong evidence
The data we hold shows that lactase is effective for lactose intolerance — that's the main well-studied use in this product. For the other enzymes, the evidence isn't established in our data.
Lipase, phytase, and acid protease all have insufficient evidence to rate them for their digestive roles. That doesn't mean they don't work; it means reliable clinical trials haven't been done yet or aren't in the research we've reviewed.
How safe is it?
Well-documented data
Lipase and lactase are generally well tolerated when used as directed. Lactase is likely safe in pregnancy, but lipase has little safety data in pregnancy so you'd want to check with your doctor first.
Both should be discussed with your healthcare provider if you're breastfeeding. Phytase and acid protease are considered low-risk in food form, but human supplement safety data are limited.
Phytase safety in pregnancy hasn't been established, so avoid it unless your doctor advises otherwise. For acid protease, safety hasn't been established in pregnancy either — it's best avoided unless prescribed.
Neither has enough breastfeeding data, so ask your doctor before using them if you're nursing. Rarely, people exposed to powdered protease occupationally have developed allergic reactions; if you have a known enzyme allergy, mention that to your pharmacist.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we were unable to verify six of the product's 15 active ingredients for drug interactions.
If you take any prescription medications, use the search tool on this page to check your specific drugs before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
This product is a solid choice if you're looking for lactase to help with lactose intolerance — that's where the evidence is strongest. If you have a serious digestive condition, check with your doctor before starting any enzyme supplement.
Pregnant or breastfeeding? Talk to your pharmacist or doctor first, especially about the phytase and acid protease ingredients.
Run your current medications through the checker on this page to make sure nothing changes how your drugs work.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 15 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Digestive Enzymes, straight from the product label.
| Brand | California Gold Nutrition |
|---|---|
| Barcode (UPC) | 898220011551 |
| Net contents | 90 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 273537 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Digestive Enzymes by California Gold Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lipase | 0 NP | -- |
| Lactase | 0 NP | -- |
| ProHydrolase | 100 mg | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Invertase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Xylanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Acid Protease | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Alpha-Galactosidase | 0 NP | -- |
| Fungal Amylase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Amylase Blend | 38 mg | -- |
| Bacterial Amylase | 0 NP | -- |
Other ingredients: Modified Cellulose, Rice Bran, Medium Chain Triglycerides powder
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule daily, with each meal. Best when taken as directed by a qualified healthcare professional.
Precautions
Warnings: Keep out of reach of children.
Consult with a licensed physician, pharmacist, naturopath or other qualified healthcare professional prior to taking dietary supplements.
Sealed for your protection. Do not use if seal is missing or broken.
Contains: Tree nuts (coconut)
This product is not manufactured with eggs, crustacean shellfish, peanuts or gluten. Produced in a third-party, audited and registered cGMP compliant facility that may process other products that contain these allergens or ingredients.
Storage
Best stored at controlled room temperature 20 degrees C to 25 degrees C (68 degrees F to 77 degrees F).
Brand IP Statement(s)
ProHydrolase is a registered trademark of Deerland Probiotics & Enzymes, Inc. California Gold Nutrition is a registered trademark of Madre Labs, LLC
Formulation
Broad Spectrum
Suitable for Vegetarians
Formulated to Contain No gluten No GMOs
This product is not manufactured with eggs, crustacean shellfish, peanuts or gluten.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Digestive Enzymes by California Gold Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Digestive Enzymes by California Gold Nutrition
These are the 15 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsLactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsProHydrolase
Cellulase
Peptidase
Invertase
Glucoamylase
Xylanase
Phytase
No knowninteractions
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and c...
Phytase monograph & interactionsAcid Protease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Acid Protease monograph & interactionsHemicellulase
Alpha-Galactosidase
Beta-Glucanase
Amylase Blend
- › Fungal Amylase
- › Bacterial Amylase
Other (inactive) ingredients: Modified Cellulose, Rice Bran, Medium Chain Triglycerides powder. These complete the product’s ingredient list but are not active constituents.
Digestive Enzymes by California Gold Nutrition Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Digestive Enzymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Digestive Enzymes, from the product label.
California Gold Nutrition
See all California Gold Nutrition products- Name
- Madre Labs, LLC
- Street Address
- 301 N. Lake Ave. #500
- City
- Pasadena
- State
- CA
- ZipCode
- 91101
- Web Address
- www.calgn.com
Digestive Enzymes by California Gold Nutrition: Common Questions
Does Digestive Enzymes by California Gold Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does this product really help with lactose intolerance?
Is it safe to take this while I'm pregnant?
Can I take this while breastfeeding?
Does it have any fillers or additives I should know about?
What are all these enzymes supposed to do?
I have a sensitive stomach. Are there any side effects I should watch for?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographLactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC