Dr. Howell's Original Formula Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Dr. Howell's Original Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Dr. Howell's Original Formula is a dietary supplement by Genuine N-Zimes with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Dr. Howell's Original Formula by Genuine N-Zimes
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 4 of its 4 active ingredients.
- “Proprietary n-zimes(R) blend” is a proprietary blend — the label doesn't break down how much of each component you get.
No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.
Why this rating?
- None of the 2 matched ingredients has a documented medication interaction on file.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 2 of 2.
- General safety write-ups exist for 2 of 2.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Dr. Howell's Original Formula, straight from the product label.
| Brand | Genuine N-Zimes |
|---|---|
| Barcode (UPC) | 707636520109 |
| Net contents | 360 Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Oct 27, 2014 |
| DSLD ID | 38071 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Dr. Howell's Original Formula by Genuine N-Zimes, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 3400 DU | -- |
| Protease | 10000 HUT | -- |
| Lipase | 36 LU | -- |
| Cellulase | 40 CU | -- |
| Proprietary n-zimes(R) blend | 0 NP | -- |
Other ingredients: Maltodextrin, Plant Fiber, Gelatin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Dr. Howell's Original Formula provides the one and only digestive enzyme blend developed by Dr. Edward Howell, the originator of food enzyme supplementation and author of the book, Enzyme Nutrition. Since his Original Formula first became available in 1932, thousands of people have found it to be safe and effective in assisting the body’s natural digestion of the protein, sugar, starch, fat and fiber found in food.*
Since 1932...
Brand IP Statement(s)
Based on his extensive clinical research, Dr. Howell created this unique n-zimes(R) blend of highly active plant enzymes found only in Genuine N-Zimes(TM) products today.
n-zimes(R) is a trademark of National Enzyme Company.
Enzymes - The Sparks of Life(TM)
Suggested/Recommended/Usage/Directions
Recommended Usage: One or two capsules with each meal or snack. Take with adequate liquid.
Precautions
Use only if tamper-evident seal is unbroken.
Keep out of reach of children.
Storage
Store tightly closed in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Digestive Enzyme Supplement
Formulation
Contains no sugar, salt, artificial sweeteners, colors or flavors, wheat, soy, yeast or dairy products.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Dr. Howell's Original Formula by Genuine N-Zimes label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Dr. Howell's Original Formula by Genuine N-Zimes
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Maltodextrin, Plant Fiber, Gelatin, Water. These complete the product’s ingredient list but are not active constituents.
Dr. Howell's Original Formula by Genuine N-Zimes Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Dr. Howell's Original Formula. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Dr. Howell's Original Formula, from the product label.
Genuine N-Zimes
See all Genuine N-Zimes products- Name
- enzymes, inc.
- City
- Kansas City
- State
- MO
- ZipCode
- 64153
- Phone Number
- 800-929-7351
Dr. Howell's Original Formula by Genuine N-Zimes: Common Questions
Does Dr. Howell's Original Formula by Genuine N-Zimes interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Dr. Howell's Original Formula is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Dr. Howell's Original Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Dr. Howell's Original Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC