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Dietary supplement

Feverfew 250 mg Ingredients & Drug Interactions

by Nature's Answer

Feverfew 250 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Feverfew 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Feverfew 250 mg is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Feverfew (Tanacetum parthenium) aerial parts extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Feverfew 250 mg by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Feverfew 250 mg by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Feverfew 250 mg by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: feverfew (Tanacetum parthenium) aerial parts extract, 250 mg per capsule. Feverfew is an herb traditionally used for headache and inflammatory conditions.

The capsule also contains inactive ingredients — rice flour, vegetable cellulose, and calcium silicate — which are fillers and binders that hold the capsule together.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Feverfew product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Feverfew's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“promotes overall health and wellbeing”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for feverfew in tension headache, psoriasis, rheumatoid arthritis, and prurigo nodularis is rated insufficient reliable evidence to rate in our data. That means the research we hold isn't robust enough yet to say whether it works for these uses or how well.

If you're considering this for a specific condition, talk it over with your doctor or pharmacist about what the broader research landscape shows.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated when taken by mouth in the short term, though some people experience gastrointestinal side effects — bloating, nausea, diarrhea, constipation, heartburn, or abdominal pain. Mouth ulceration and irritation can happen, especially if you chew fresh feverfew leaves rather than take a capsule.

Some people may have allergic reactions or skin rashes. Avoid feverfew during pregnancy — it may stimulate the uterus and safety isn't established.

There isn't enough reliable safety information to use it while breastfeeding either. If you've been taking feverfew for a long time and stop suddenly, you may experience "post-feverfew syndrome," with symptoms like anxiety, headaches, and insomnia — taper gradually if you've been on it long-term.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your own doctor or pharmacist if you're on blood thinners or antiplatelet drugs like warfarin or aspirin — feverfew may increase bleeding risk. Also flag any medication your liver handles heavily (many blood pressure drugs, antidepressants, statins, immunosuppressants, and others), since lab research suggests feverfew might inhibit several liver enzymes and theoretically raise drug levels, even though this hasn't been confirmed in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Feverfew is one to clear with your doctor or pharmacist before you start, mainly because of its potential to interact with blood thinners and the many drugs your liver processes. It's generally well tolerated in the short term, but evidence for its effectiveness in the conditions it's marketed for is still not solid.

If you're on any regular medication, check it against this product's interactions first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Feverfew 250 mg, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000163814
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 208447
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Feverfew 250 mg by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
45
UPC/BARCODE
083000163814
IngredientAmount% DV
Feverfew (Tanacetum parthenium) aerial parts extract250 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Discover Nature's Answer and trust the difference... The true nature of our standards go way beyond the herb...

Since 1972

Promotes overall health & wellbeing

Discover Nature's Answer

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Seals/Symbols

Gluten Free

Formula

Tanacetum parthenium

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten-Free

Vegan

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one (1) capsule two (2) times a day with food or water.

Precautions

Warning: Keep out of reach of children.

Do not use if safety seal is damaged or missing.

If you are pregnant, nursing, taking any medications, planning any medical procedure or have a medical condition, consult with your healthcare practitioner before use.

Brand IP Statement(s)

2018 Nature’s Answer

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Feverfew 250 mg by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Feverfew 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Feverfew 250 mg by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Feverfew (Tanacetum parthenium) aerial parts extract

Interacts with
929 drugs
250 mg per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Feverfew (Tanacetum parthenium) aerial parts extract monograph & interactions

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Feverfew 250 mg by Nature's Answer Drug Interactions

Want to check YOUR meds against Feverfew 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

Feverfew (Tanacetum parthenium) aerial parts extract 929

Individual Drug Interactions

The ingredients in Feverfew 250 mg interact with 929 drugs. Click any drug to see the details.

1 of the 1 ingredient in Feverfew 250 mg interact with drugs. Each result below shows which ingredient is responsible. Feverfew (Tanacetum parthenium) aerial parts extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Feverfew 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Feverfew (Tanacetum parthenium) aerial parts extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Feverfew (Tanacetum parthenium) aerial parts extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Feverfew 250 mg, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Feverfew 250 mg by Nature's Answer: Common Questions

Does Feverfew 250 mg by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Feverfew 250 mg has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Feverfew 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take feverfew if I'm pregnant or breastfeeding?
No — feverfew is rated possibly unsafe in pregnancy because it may stimulate the uterus and its safety isn't established. There also isn't enough reliable safety information to use it while breastfeeding. Talk with your own doctor about whether this product is right for you in either situation.
What side effects might I get from taking feverfew?
Most commonly, people experience digestive upset — nausea, diarrhea, constipation, bloating, heartburn, or abdominal pain. Mouth ulceration and irritation can happen too, especially if you chew fresh leaves rather than take a capsule form. Some people may have allergic reactions or develop a rash. If you stop after taking it long-term, you might experience anxiety, headaches, or insomnia.
Does feverfew actually work for tension headaches?
The evidence we hold is rated insufficient reliable evidence to rate, which means the research isn't solid enough yet to say whether it's effective for that use. You'd want to discuss what the broader research shows with your doctor or pharmacist before relying on it for headache management.
Why does this product interact with so many medications?
Feverfew can inhibit several liver enzymes (CYP3A4, CYP2D6, CYP2C19, CYP2C9, CYP1A2, and CYP2C8) that your body uses to break down drugs. Because hundreds of different medications are processed through at least one of those pathways, the total number of potentially affected drugs is very large — even though the interaction hasn't been confirmed in actual patients yet.
Is feverfew safe to use with blood thinners like warfarin?
No — feverfew may increase bleeding risk when combined with blood thinners or antiplatelet drugs. Lab research shows it may inhibit platelet aggregation, and there's even one case report of vaginal bleeding in a patient taking high-dose feverfew. You must talk with your own doctor or pharmacist before using this product if you're on a blood thinner.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Feverfew 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Feverfew 250 mg label
Go deeper

The Full Monographs Behind Feverfew 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

Feverfew 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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