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Calcium is a vital nutrient found in various foods such as dairy products, certain vegetables, and many fortified items. Over 99% of the body's calcium is stored in the bones and teeth, predominantly as hydroxyapatite. The remaining calcium circulates in the blood, extracellular fluid, muscles, and other tissues, where it is essential for processes like nerve signaling, muscle contraction, vascular activities, glandular secretion, and maintaining cell membrane and capillary permeability. It also plays critical roles in enzyme reactions, respiration, kidney function, and blood clotting, and is involved in neurotransmitter and hormone release, amino acid uptake, vitamin B12 absorption, and gastrin secretion. Calcium balance changes with age: it is positive during periods of growth, stable in adulthood, and tends to become negative in older age. Calcium loss occurs through feces, urine, sweat, and shedding skin cells. In women, reduced estrogen levels decrease calcium absorption and retention, increase bone turnover, and lead to lower bone mass. Calcium supplements come in various forms, including citrate and carbonate, which differ mainly in their calcium content and absorption rates. Calcium citrate is easily absorbed and can be taken without food, making it suitable for older adults or those with low stomach acid. In contrast, calcium carbonate, which contains a higher percentage of calcium, is best absorbed when taken with meals.

Magnesium is a mineral that is essential for the proper functioning of the body. It plays a role in many important physiological processes, including the contraction and relaxation of muscles, the transmission of nerve impulses, and the regulation of blood pressure. Magnesium is found in a variety of foods, including leafy green vegetables, nuts, and grains, and it is also available as a dietary supplement. There are several different forms of magnesium that are available as supplements, all of which can be used to prevent deficiency. Additionally, magnesium is purported to have several different health benefits, such as improving sleep, reducing muscle cramps, reducing anxiety, and preventing or treating migraines. Although magnesium is essential for health, magnesium-containing foods and supplements can interact with some prescription medications if used at the same time.

Silicon, atomic number 14, is the second most abundant element on Earth, after oxygen. It is present in the human body in small amounts (such as in the skin, hair, and nails) and is considered a trace mineral in that regard. Dietary sources of silicon include oats, barley, rice, and some fruits/vegetables. Silicon is a popular dietary supplement, often consumed in the form of silica, which is a chemical compound made up of silicon and oxygen, or as silicic acid (also known as orthosilicic acid). Another common form of silicon utilized is Choline-stabilized orthosilicic acid (ch-OSA), which is the active ingredient in the popular product Biosil. Silicon is used for its purported effects to improve the health and appearance of the skin, hair, and nails. It has also historically been used for other health conditions, such as osteoporosis, cardiovascular disease, and cognitive decline.

Choline is an essential nutrient that is found in many foods, including eggs, and is important for a number of bodily functions, including liver function, brain development, and nerve function. Choline is a precursor to acetylcholine, a neurotransmitter that plays a role in memory, mood, and muscle control. Choline also helps to transport fats out of the liver, which may help to reduce the risk of liver disease. Choline supplements are available in different forms, including choline bitartrate, choline chloride, and phosphatidylcholine. Choline bitartrate is the most common form of choline supplement, but phosphatidylcholine is the form that is found naturally in foods.