Gluten Manager Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Gluten Manager against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Gluten Manager is a dietary supplement by Integrative Therapeutics with 2 active ingredients.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Gluten Manager by Integrative Therapeutics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Gluten Manager contains three active ingredients, all enzymes designed to help break down gluten and other proteins. Protease II and Protease V are both proteolytic enzymes (protein-digesting enzymes), and Dipeptidyl Peptidase-IV is another enzyme that breaks down specific peptide chains.
The product also includes a proprietary blend of Microbial Enzymes to support digestion. The capsule itself is made from hydroxypropyl methylcellulose (a plant-based shell), with cellulose, calcium laurate, and silicon dioxide as inactive ingredients.
Does it work?
Couldn't assess
The product facts we have don't include effectiveness ratings for any of the active ingredients in Gluten Manager. That means the evidence for how well these enzymes work to help with gluten digestion isn't established in the data we hold.
If you're considering this product for a specific purpose, it's worth talking with your doctor or pharmacist about what the research actually shows.
How safe is it?
Well-documented data
Protease II and Protease V are generally well tolerated for most adults, though some people may experience digestive upset or allergic reactions. Because these are enzymes similar to those found in laundry products, rarely some people have developed allergic responses to protease exposure (through skin contact or inhalation in occupational settings).
For pregnancy, the safety data isn't established for these proteolytic enzymes, so they're best avoided during pregnancy unless your doctor specifically prescribes them. During breastfeeding, there's very little safety data available, so use is not recommended without talking it over with your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check in Gluten Manager. However, we weren't able to obtain interaction data for Tolerase G Prolyl Endopeptidase, so check your specific medications with the search tool on this page to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Gluten Manager may be worth considering if you're looking to support gluten digestion with enzyme supplements, and the ingredients we checked show no documented drug interactions. However, we don't have effectiveness data on file to tell you how well it works.
If you're pregnant, breastfeeding, or have a history of allergic reactions to proteases, talk with your doctor or pharmacist before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Gluten Manager, straight from the product label.
| Brand | Integrative Therapeutics |
|---|---|
| Barcode (UPC) | 871791119567 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2021 |
| DSLD ID | 242303 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Gluten Manager by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Dipeptidyl Peptidase-IV | 0 NP | -- |
| Protease II | 0 NP | -- |
| Protease V | 0 NP | -- |
| Microbial Enzymes | 731 mg | -- |
| Tolerase G Prolyl Endopeptidase | 0 NP | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Cellulose, Calcium Laurate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Keep out of reach of children.
Safety sealed with inner seal. Do not use if seal is broken or missing.
Tolerase G is not intended to replace a gluten-free diet. Tolerase G is not intended to treat or prevent celiac disease.
Caution: While Gluten Manager will reduce the level of reactive gliadin and gluten proteins in a meal, it is advised that celiac disease sufferers continue with their normal gluten exclusion diet as even small amounts of gliadin can cause adverse reactions in the most sensitized individuals.
If you are pregnant, nursing, or taking prescription drugs, consult your healthcare professional prior to use.
Brand IP Statement(s)
Tolerase G is a trademark of DSM.
Copyright 2020 Distributed by Integrative Therapeutics, LLC
Formulation
Contains no gluten, dairy products, ingredients of animal origin, or artificial colors, flavors, or preservatives.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Take 1 or 2 capsules at the beginning of each meal or as recommended by your healthcare professional.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Gluten Manager by Integrative Therapeutics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Gluten Manager by Integrative Therapeutics
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Microbial Enzymes
- › Dipeptidyl Peptidase-IV
- › Tolerase G Prolyl Endopeptidase
Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Cellulose, Calcium Laurate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Gluten Manager by Integrative Therapeutics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Gluten Manager. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Gluten Manager, from the product label.
Integrative Therapeutics
See all Integrative Therapeutics products- Name
- Integrative Therapeutics, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 800.931.1709
- Web Address
- integrativepro.com
Gluten Manager by Integrative Therapeutics: Common Questions
Does Gluten Manager by Integrative Therapeutics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Gluten Manager if I'm pregnant?
Is it safe to use Gluten Manager while breastfeeding?
What are the side effects I might experience?
Does this product contain any fillers?
What do these enzymes actually do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Gluten Manager is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
Sources & How We Checked
Gluten Manager's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC