Glycine Ingredients & Drug Interactions
by Thorne
What is this page for?
First and foremost: checking Glycine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Glycine is a dietary supplement by Thorne with 1 active ingredient. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Glycine by Thorne
Ask about any prescription or over-the-counter medication and we check it for interactions with Glycine by Thorne — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Glycine by Thorne
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains a single active ingredient: glycine, an amino acid your body naturally produces. Glycine plays a role in protein synthesis and acts as a neurotransmitter in your central nervous system.
The capsule itself is made from inactive ingredients including hypromellose and silicon dioxide, which help form and stabilize the capsule.
Does it work?
Not established
The evidence for glycine in schizophrenia is rated possibly effective, meaning some research supports its use, though more robust studies are needed. For other conditions listed — 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency, ADHD, benign prostatic hyperplasia (enlarged prostate), and cystic fibrosis — we don't have enough reliable evidence to say whether it works.
How safe is it?
Well-documented data
Glycine is generally well tolerated at typical doses, but long-term safety data are limited. Rarely, people have reported mild sedation, irritability, insomnia, fatigue, memory issues, headache, and sensory changes — though we can't always confirm glycine caused them.
Mild GI upset (soft stools, nausea, vomiting, upper stomach discomfort) and dry mouth have also been reported rarely and typically improve quickly if you stop taking it. There isn't enough reliable safety data for pregnancy or breastfeeding, so it's best to avoid it unless your doctor specifically approves.
Meds to double-check
Moderate interaction found
If you take clozapine (Clozaril) for schizophrenia, do not start this supplement without talking to your doctor or pharmacist first — glycine may reduce its effectiveness and worsen your symptoms.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Glycine may help with schizophrenia symptoms according to some research, though the evidence isn't conclusive yet. The main concern is if you take clozapine — this supplement may interfere with how well it works.
Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or taking any psychiatric medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Glycine, straight from the product label.
| Brand | Thorne |
|---|---|
| Barcode (UPC) | 693749512028 |
| Net contents | 250 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 336341 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Glycine by Thorne, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Glycine | 1 Gram(s) | -- |
Other ingredients: Hypromellose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Foundational Stress Liver/detox
Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take 2 capsules one to three times daily or as recommended by your health-care practitioner.
Precautions
Tamper evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Storage
Store tightly sealed in a cool, dry place.
Seals/Symbols
NSF Contents Certified
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Glycine by Thorne label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Glycine by Thorne
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container125 Amounts shown are per serving.
Glycine
Interacts with1 drug
Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep q...
Glycine monograph & interactionsOther (inactive) ingredients: Hypromellose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Glycine by Thorne Drug Interactions
HelloPharmacist Interaction Report
Thorne Glycine has one documented interaction we need to flag: it may reduce how well clozapine (Clozaril), an antipsychotic medication for schizophrenia, works.
A small clinical study showed that adding glycine to clozapine therapy actually worsened schizophrenia symptoms compared with clozapine alone, though we don't yet understand exactly why this happens.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 1 individual medication. If you take clozapine, check with your pharmacist or doctor before adding this supplement — you may need to adjust your dosing or skip glycine altogether.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Glycine?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Glycine interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Glycine interact with drugs. Each result below shows which ingredient is responsible. Glycine
ClozapineClozaril, Versacloz
How Clozapine interacts with Glycine — through 1 ingredient. Tap an ingredient for the detail:
GlycineClozapine (clozaril) Moderate
Interaction Summary
Theoretically, glycine might decrease the effectiveness of clozapine.
Read the full Glycine + Clozapine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Glycine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Glycine
Clozapine (Clozaril)
Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.
Brand information
Manufacturer and brand details for Glycine, from the product label.
Glycine by Thorne: Common Questions
Does Glycine by Thorne interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will glycine help my schizophrenia?
Are there side effects I should know about?
Is it safe to take while pregnant or breastfeeding?
What is glycine and why would I take it?
Does this supplement have fillers or other ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Glycine is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Glycine’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Glycine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Glycine 5 references
- Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
- Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
- Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
- Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
- Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC