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Agmatine is an endogenous polyamine found in bacteria, plants, and animals, including humans, synthesized from the amino acid arginine. It plays a crucial role in various physiological processes, including neurotransmission, nitric oxide synthesis, and cellular metabolism. In dietary supplements, agmatine is proposed to support mental health, cognitive function, and overall well-being. It's most common use is as a pre and post-workout supplement.

Phenethylamine (PEA) is a monoamine alkaloid present in various sources, including plants, bacteria, fungi, and animals, including humans. It is also found in certain foods like chocolate and eggs. This compound is synthesized in the body through the decarboxylation of the amino acid L-phenylalanine. Within the central nervous system, PEA serves as both a neuromodulator and neurotransmitter, playing a crucial role in neuronal signaling. Phenethylamine is available as a dietary supplement and is used for potential cognitive and mood-enhancing effects, although further research is needed to fully understand its effects in these regards.

Theanine, often referred to as L-theanine as that is the predominant isomer of theanine, is an amino acid commonly found in tea leaves, particularly in green tea. It is purported to increase levels of GABA, serotonin, and dopamine in the brain, which can help to reduce stress and anxiety. L-theanine may also promote a sense of calm and improve overall well-being. Some studies have also suggested that it may improve cognitive function, although more research is needed. Most reported drug interactions with theanine are due to its sedative effects.

Choline is an essential nutrient that is found in many foods, including eggs, and is important for a number of bodily functions, including liver function, brain development, and nerve function. Choline is a precursor to acetylcholine, a neurotransmitter that plays a role in memory, mood, and muscle control. Choline also helps to transport fats out of the liver, which may help to reduce the risk of liver disease. Choline supplements are available in different forms, including choline bitartrate, choline chloride, and phosphatidylcholine. Choline bitartrate is the most common form of choline supplement, but phosphatidylcholine is the form that is found naturally in foods.

Hordenine is a naturally occurring alkaloid found in various plants, including barley and cacti. It is structurally related to epinephrine and ephedrine and gets its name from the Hordeum genus of barley, from which it was first isolated. Hordenine has been marketed as a dietary supplement with claims of boosting energy and athletic performance, but there is limited scientific evidence to support these claims. Some studies suggest that it may have properties as a stimulant, but further research is needed to confirm its effects and safety.