Graviola 500 mg Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Graviola 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Graviola 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Soursop. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Graviola 500 mg by NOW
Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 500 mg by NOW — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Graviola 500 mg by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: soursop (also called graviola), at 500 mg per capsule. The capsule also contains hypromellose, magnesium stearate, and silicon dioxide as inactive ingredients to hold it together.
Does it work?
Not established
The evidence we hold doesn't support graviola for any condition yet. It's been studied for HPV, headache, insect repellent properties, and male infertility, but the data isn't strong enough to rate it as effective for any of these uses.
That doesn't mean it doesn't work — just that solid evidence isn't established in the sources we have.
How safe is it?
Well-documented data
Graviola is generally well tolerated in short-term use, but regular consumption raises some caution flags. Lab studies suggest possible nerve toxicity with long-term use, and the most common side effects reported in a clinical trial were nausea and burning pain in the upper abdomen.
Rare but serious concerns include movement disorders and myeloneuropathy (nerve damage) that can resemble Parkinson disease symptoms. One large study in Parkinson patients found that even small amounts of graviola fruit, juice, or tea were linked to worsening motor and thinking symptoms.
Don't use graviola during pregnancy or while breastfeeding — the safety data are not adequate to support it, and traditional use has favored avoiding it in both situations.
Meds to double-check
Moderate interaction found
If you take carbamazepine (Tegretol) for seizures, check with your pharmacist or doctor before starting graviola — it may lower the drug's effectiveness and put you at risk for breakthrough seizures.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Graviola may appeal to you if you're exploring herbal options, but the evidence for what it actually does isn't solid yet. The bigger concern is if you take carbamazepine for seizures — graviola could interfere with it.
Talk to your pharmacist before starting this product, especially if you're on any regular medications, pregnant, or nursing.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Graviola 500 mg, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739047038 |
| Net contents | 100 Veg Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 245885 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Graviola 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Soursop | 1 Gram(s) | -- |
Other ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 2 capsules 3 to 4 times daily as needed.
Formula
Graviola tree (Annona muricata), also known as soursop, is found in tropical areas of the world. Its leaves have a long history of use by traditional herbalists. More recent scientific studies suggest that Acetogenins, the active constituents of Graviola, can support healthy cell growth and function. Other active compounds found in Graviola leaves have free radical scavenging properties.
Free radical scavenger
Triangle K (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only.
Do not take this product if you have any neurodegenerative disorders or Parkinson’s disease, or are taking any antihypertensive or MAO inhibitor medications. Not recommended for pregnant/nursing women. Consult physician if taking medication or have a medical condition.
Keep out of reach of children.
Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Healthy cell funtion
Non GMO Project Verified nongmoproject.org
Vegetarian/vegan
Not manufactured with yeast, wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients.
Seals/Symbols
Non GMO Project Verified nongmoproject.org
Triangle K (Kosher)
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
General Statements
Botanicals/herbs Family owned since 1968.
Storage
Store in a cool, dry place after opening.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Graviola 500 mg by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Graviola 500 mg by NOW
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Veg Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Soursop
Interacts with1 drug
Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...
Soursop monograph & interactionsOther (inactive) ingredients: Hypromellose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Graviola 500 mg by NOW Drug Interactions
HelloPharmacist Interaction Report
NOW's Graviola 500 mg contains soursop, which has one documented interaction.
The main concern is with carbamazepine (Tegretol), a seizure medication. Graviola may lower how much carbamazepine stays in your bloodstream — a rat study showed it reduced carbamazepine levels by about 35–46%, which could make the medication less effective at controlling seizures.
Read the full breakdown — every affected drug type, severity by severity
If you take carbamazepine, don't start graviola without checking with your doctor or pharmacist first. We've checked the ingredient against our interaction data, and carbamazepine is the only medication type with documented interactions for this product.
Run your exact medications through the checker below to be sure.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Graviola 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Graviola 500 mg interact with 1 drug. Click any drug to see the details.
1 of the 1 ingredient in Graviola 500 mg interact with drugs. Each result below shows which ingredient is responsible. Soursop
CarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Graviola 500 mg — through 1 ingredient. Tap an ingredient for the detail:
SoursopCarbamazepine (tegretol) Moderate
Interaction Summary
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
Read the full Soursop + Carbamazepine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Graviola 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Soursop
Carbamazepine (Tegretol)
Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.
Brand information
Manufacturer and brand details for Graviola 500 mg, from the product label.
NOW
See all NOW products- Name
- NOW Foods
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
Graviola 500 mg by NOW: Common Questions
Does Graviola 500 mg by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the side effects?
Does graviola actually work for anything?
What is soursop?
Are there any fillers in this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Graviola 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Graviola 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Graviola 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Graviola 4 references
- Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
- Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
- Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
- Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC