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Dietary supplement

Holy Basil Extract 450 mg Ingredients & Drug Interactions

by Planetary Herbals

Holy Basil Extract 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Holy Basil Extract 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Holy Basil Extract 450 mg is a dietary supplement by Planetary Herbals with 1 active ingredient. Its ingredients are commonly taken for stress and anxiety, blood sugar support, respiratory complaints.Based on those ingredients, 212 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Holy Basil Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Holy Basil Extract 450 mg by Planetary Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Holy Basil Extract 450 mg by Planetary Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Holy Basil Extract 450 mg by Planetary Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: holy basil leaf extract, 450 mg per capsule. Holy basil — also called tulsi — is an herb traditionally used in Ayurvedic medicine.

The capsule itself is made from gelatin, microcrystalline cellulose, and magnesium stearate, which are common inactive ingredients that help form and preserve the supplement.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Holy Basil's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote centered calmness.
  • We looked for evidence on: Stress, Generalized anxiety disorder (GAD), Insomnia, tension relief, mental clarity.
  • The closest evidence on file: Holy Basil is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD) (Natural Medicines).
  • Also on file: Holy Basil is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress.

The evidence for holy basil extract is insufficient to rate how well it works. The facts we hold show insufficient reliable evidence for its use in generalized anxiety, asthma, headache, respiratory infections, dental plaque, and diabetes.

That doesn't mean it doesn't work — it means the research isn't yet robust enough to establish it clearly. If you're considering this for a specific health concern, talk it over with your doctor or pharmacist about whether the available evidence and your individual situation support a trial.

The evidence, ingredient by ingredient Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Holy basil extract is generally well tolerated short-term in adults, though high-quality long-term safety data are limited. The most common side effects reported orally are loose stools and nausea; a small number of trial participants (2 out of 24) experienced these.

If used topically, such as in a mouthwash, a bitter taste has been reported. Because animal data raise safety concerns and human safety data are not established, the facts advise against use during pregnancy and while breastfeeding.

If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product — they can help you weigh what you know about your situation against the uncertainty here.

Side effects, ingredient by ingredient Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (including aspirin, warfarin, or clopidogrel) — there's a moderate risk of increased bleeding. Also double-check if you're on diabetes medications, since holy basil may lower your blood sugar.

If you take pentobarbital (Nembutal) or other sedatives, mention this product as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Holy Basil Extract by Planetary Herbals is generally well tolerated for short-term use in adults, but the evidence for what it actually does isn't yet solid. If you take blood thinners, diabetes medications, or pentobarbital, you'll want to check with your doctor or pharmacist before starting it — these combinations carry documented interaction risks.

Pregnant and breastfeeding individuals should talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Holy Basil Extract 450 mg, straight from the product label.

Brand Planetary Herbals
Barcode (UPC) 021078105305
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2018
DSLD ID 182758
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Holy Basil Extract 450 mg by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
021078105305
IngredientAmount% DV
Holy Basil Leaf Extract450 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Promoted centered calmness

Approved by Michael Tierra L.Ac, O.M.D

It is a powerful adaptogen that helps your body adapt to the negative effects of stress. During times of stress, our bodies secrete higher levels of cortisol.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule daily between meals.

Precautions

Warning: Do not use if you are pregnant, may become pregnant, or breastfeeding.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Formula

Holy Basil (also known as tulsi) is one of the primary botanicals used in Ayurvedic practice in India.

Preliminary research has suggested that Holy Basil may help maintain normal cortisol levels, support healthy adrenal glands, and help maintain normal blood sugar levels.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

PF0530 REV B161

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Holy Basil Extract 450 mg by Planetary Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Holy Basil Extract 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Holy Basil Extract 450 mg by Planetary Herbals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Holy Basil Leaf Extract

Interacts with
212 drugs
450 mg per serving

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Holy Basil Leaf Extract monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Holy Basil Extract 450 mg by Planetary Herbals Drug Interactions

Want to check YOUR meds against Holy Basil Extract 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
212Drugs
212 Moderate

Ingredients driving the most interactions

Holy Basil Leaf Extract 212

Individual Drug Interactions

The ingredients in Holy Basil Extract 450 mg interact with 212 drugs. Click any drug to see the details.

1 of the 1 ingredient in Holy Basil Extract 450 mg interact with drugs. Each result below shows which ingredient is responsible. Holy Basil Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Holy Basil Extract 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Holy Basil Leaf Extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
Holy Basil Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Holy Basil Extract 450 mg, from the product label.

Planetary Herbals

See all Planetary Herbals products
Name
Planetary Herbals, LLC
Street Address
P.O. Box 1760
City
Soquel
State
CA
ZipCode
95073
Web Address
www.planetaryherbals.com
Pharmacist Counseling Corner

Holy Basil Extract 450 mg by Planetary Herbals: Common Questions

Does Holy Basil Extract 450 mg by Planetary Herbals interact with any medications?
Yes. Based on its ingredients, Holy Basil Extract 450 mg has a known interaction with 212 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Holy Basil Extract 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against it during both pregnancy and breastfeeding because animal research raises concerns and human safety isn't established. Talk with your doctor or pharmacist — they can help you decide what's right for your situation.
What are the most common side effects?
Orally, loose stools and nausea are most common, though they're rare — only 2 out of 24 trial participants in one study reported them. If you use it topically, like in a mouthwash, bitter taste has been reported.
Does holy basil actually work for anxiety, asthma, or diabetes?
The evidence in our data is insufficient to rate how well it works for any of these conditions — generalized anxiety, asthma, headache, respiratory infections, dental plaque, and diabetes all show insufficient reliable evidence. That means we don't yet have strong enough research to say yes or no.
How long is it safe to take this?
It's generally well tolerated short-term in adults, but high-quality long-term safety data are limited, so we don't have solid information on safety beyond that window.
Why are there so many drug interactions listed?
Holy basil may affect how your blood clots and how your body handles blood sugar and sedatives, which means it can interact with any medication in those categories — that's why the total number is high even though the ingredient count is just one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Holy Basil Extract 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Holy Basil Extract 450 mg label
Go deeper

The Full Monographs Behind Holy Basil Extract 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Holy Basil

Interacts with 212 drugs

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and preliminary. It is generally well tolerat...

Read the full Holy Basil monograph →
Sources

Sources & How We Checked

Holy Basil Extract 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Holy Basil 8 references
  1. Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
  2. Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
  3. Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
  4. Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
  5. Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
  6. Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
  7. Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
  8. Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

See these in context on the Holy Basil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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