Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Hunger Support Orange Mango Ingredients & Drug Interactions

by GNC Total Lean

Hunger Support Orange Mango label
See full label image
Powder Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hunger Support Orange Mango against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hunger Support Orange Mango is a dietary supplement by GNC Total Lean with 4 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,053 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Apple Cider Vinegar powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hunger Support Orange Mango by GNC Total Lean

Ask about any prescription or over-the-counter medication and we check it for interactions with Hunger Support Orange Mango by GNC Total Lean — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Hunger Support Orange Mango by GNC Total Lean

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder has 3 active ingredients. Apple cider vinegar powder provides acetic acid and compounds from fermented apples.

Litesse Polydextrose Fiber is a soluble fiber used to add bulk and support digestive function. BiMuno B-Gos Galactooligosaccharides is a prebiotic fiber ingredient, though we hold no interaction or safety data for it.

The product also contains several inactive ingredients—fillers, binders, and flavorings like citric acid, natural and artificial flavors, sucralose, and food coloring.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: feel fuller longer eat less.
  • We looked for evidence on: Obesity, Weight management, Appetite suppression, Satiety.
  • The closest evidence on file: Black Psyllium is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Apple Cider Vinegar is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Polydextrose is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence we hold doesn't establish that apple cider vinegar works for acne, athletic performance, cognitive function, dental plaque, depression, or atopic dermatitis (eczema)—the data shows insufficient reliable evidence to rate it for any of these uses. Polydextrose is rated with insufficient evidence for upper respiratory tract infection, constipation, diabetes, irritable bowel syndrome, or obesity.

We have no effectiveness data on file for BiMuno B-Gos Galactooligosaccharides.

The evidence, ingredient by ingredient Black Psyllium Apple Cider Vinegar Polydextrose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple cider vinegar in food amounts is generally well tolerated, but large doses or long-term medicinal use carry more risk. The most serious concern is hypokalemia (low potassium), especially with chronic use—a documented case involved 250 mL daily for 6 years and resulted in low potassium, elevated renin levels, and osteoporosis.

Short-term oral use for medicinal purposes seems well tolerated in smaller amounts. Topically, undiluted apple cider vinegar can cause chemical burns and skin irritation.

Polydextrose is generally recognized as safe in food amounts. At supplement-level doses above 50 grams per dose or 90 grams daily, it commonly causes bloating, gas, and diarrhea.

We hold no pregnancy or lactation safety data for any of these ingredients—talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Black Psyllium Apple Cider Vinegar Polydextrose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Black Psyllium, Apple Cider Vinegar.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,054 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this powder, double-check it with your doctor or pharmacist if you take diuretic drugs (water pills), digoxin (Lanoxin), insulin, or antidiabetes medications like metformin or sulfonylureas. Apple cider vinegar can lower potassium and blood sugar, making these drugs less safe or more potent.

No interactions are documented for the polydextrose or galactooligosaccharides ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly a concern if you take diuretics, digoxin, insulin, or antidiabetes medications—the apple cider vinegar can interact meaningfully with all of them. If you're on any of those drugs or have a history of low potassium, check with your doctor or pharmacist before starting.

Even without those medications, stick to normal serving sizes and don't use it long-term without medical guidance, since heavy, chronic use of apple cider vinegar carries real risks.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hunger Support Orange Mango, straight from the product label.

Brand GNC Total Lean
Barcode (UPC) 048107196882
Net contents 17.46 oz; 1.1 lb(s); 495 Gram(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 213508
Product type Botanical With Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hunger Support Orange Mango by GNC Total Lean, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
16.5 Gram(s)
Maximum serving Sizes:
16.5 Gram(s)
Servings per container
15
UPC/BARCODE
048107196882
IngredientAmount% DV
Calories80 Calorie(s)--
Total Carbohydrates30 Gram(s)11%
Dietary Fiber22 Gram(s)79%
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Apple Cider Vinegar powder1000 mg--
Litesse Polydextrose Fiber12.5 Gram(s)--
BiMuno B-Gos Galactooligosaccharides2.74 Gram(s)--

Other ingredients: soluble vegetable Fiber, Citric Acid, Natural & Artificial flavors, Sunfiber, Silicon Dioxide, Lactose, Sucralose, Malic Acid, Glucose, Acesulfame Potassium, FD&C Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Tastes great, more filling. You work hard on your fitness goals, and that includes eating healthy. But sometimes it seems temptation is everywhere. Add GNC's Hunger Support Powder to your regimen. It helps you feel fuller, longer - and it tastes delicious!

In three separate placebo-controlled, clinical trials involving 86 participants, consumption of 12.5 g of Litesse Fiber in a pre-meal beverage resulted in a statistically significant reduction in caloric intake in a subsequent test meal (lunch). The subjects' breakfast meal was controlled, as was the nutritional profile of the test beverage. In a randomized, double-blind, placebo-controlled, crossover trial, where 83 individuals took a daily dose of 1.37 g B-GOS and placebo for 14 days each, during which B-GOS subjects experienced statistically significant improvements in bloating and digestive comfort at the 7- and 14-day time points, compared to placebo.

Formula

Excellent source of fiber, including Litesse, which is clinically shown to reduce calorie consumption when taken before a meal Increases your feeling of fullness and satiety so you eat less and wait longer between meals Provides an effective aid to eliminate unwanted toxins from the body and supports digestive health Includes Bimuno Prebiotic, which improves digestive comfort and bloating in as little as 7 days

Excellent source of fiber plus prebiotics for digestive health

Natural & artificial flavor

Precautions

Keep out of reach of children.

Contains: Milk

Storage

Store in a cool, dry place.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Clinically Studied

Formulation

Clinically shown to reduce food intake Helps you to eat less and wait longer between meals

Contributes a trivial amount of sugar.

No sugar

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, add one scoop to 8 to 10 fl. oz. of water, mix thoroughly and enjoy twice daily. For optimal hunger support benefits, take both servings together 60-90 minutes before our largest meal of the day. Consume with adequate amounts of water.

Brand IP Statement(s)

Bimuno, B-GOS and the Bimuno ICON are registered trademarks of Clasado IP Limited and are protected by patents 7,883,874, 8,058,047, 8,030,049 and 8,168,414. Litesse is a trademark of DuPont used under license by GNC. Sunfiber is a registered trademark of Taiyo International, Inc. Use of Sunfiber is protected by US Trademark Registration No. 2,930,937.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hunger Support Orange Mango by GNC Total Lean label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hunger Support Orange Mango label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hunger Support Orange Mango by GNC Total Lean

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size16.5 Gram(s) Dosage formPowder Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
22 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Apple Cider Vinegar powder

Interacts with
162 drugs
1000 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar powder monograph & interactions

Litesse Polydextrose Fiber

No known
interactions
12.5 Gram(s) per serving

Polydextrose is a man-made soluble fiber used widely in foods as a low-calorie bulking agent and prebiotic. It is generally well tolerated, though lar...

Litesse Polydextrose Fiber monograph & interactions

BiMuno B-Gos Galactooligosaccharides

2.74 Gram(s) per serving

Other (inactive) ingredients: Soluble vegetable Fiber, Citric Acid, Natural & Artificial flavors, Sunfiber, Silicon Dioxide, Lactose, Sucralose, Malic Acid, Glucose, Acesulfame Potassium, FD&C Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hunger Support Orange Mango by GNC Total Lean Drug Interactions

Want to check YOUR meds against Hunger Support Orange Mango?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,053Drugs
112 Moderate 1,941 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Apple Cider Vinegar powder 162

Individual Drug Interactions

The ingredients in Hunger Support Orange Mango interact with 2,053 drugs. Click any drug to see the details.

2 of the 4 ingredients in Hunger Support Orange Mango interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Apple Cider Vinegar powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Hunger Support Orange Mango with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Apple Cider Vinegar powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hunger Support Orange Mango, from the product label.

GNC Total Lean

See all GNC Total Lean products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Hunger Support Orange Mango by GNC Total Lean: Common Questions

Does Hunger Support Orange Mango by GNC Total Lean interact with any medications?
Yes. Based on its ingredients, Hunger Support Orange Mango has a known interaction with 2,053 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hunger Support Orange Mango contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this powder have any side effects?
Apple cider vinegar in the amounts used here is generally well tolerated short-term. The main risks come with heavy or long-term use—low potassium levels and bone loss have been reported. The polydextrose fiber can cause bloating, gas, or loose stools, especially at doses over 50 grams per serving.
What is polydextrose, and why is it in this product?
Polydextrose is a soluble fiber added to increase fullness and support digestive health. It's well tolerated at normal food levels, though it may cause some gas or bloating when you first use it or in larger amounts.
Is this safe to use during pregnancy or while breastfeeding?
We don't have safety data on file for any of these ingredients during pregnancy or lactation. Talk with your doctor or pharmacist—they can weigh the risks and benefits for your situation.
Will this product help me lose weight or suppress my appetite?
The evidence we hold doesn't show that apple cider vinegar or polydextrose reliably works for obesity or appetite. The facts don't establish their effectiveness for weight loss or hunger control.
Can I use this every day?
Short-term daily use of apple cider vinegar seems well tolerated in normal amounts, but the data on long-term supplemental doses is limited. Start with normal servings and talk with your doctor or pharmacist about how long to use it safely.
What is BiMuno B-Gos, and is it safe?
BiMuno B-Gos is a prebiotic galactooligosaccharide fiber. We hold no interaction, safety, or effectiveness data for it, so we can't tell you whether it's well tolerated or what it does. Your doctor or pharmacist can help you assess it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hunger Support Orange Mango is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hunger Support Orange Mango label
Go deeper

The Full Monographs Behind Hunger Support Orange Mango’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Polydextrose

Polydextrose is a man-made soluble fiber used widely in foods as a low-calorie bulking agent and prebiotic. It is generally well tolerated, though large amounts can cause gas, bloating, or l...

Read the full Polydextrose monograph →
Sources

Sources & How We Checked

Hunger Support Orange Mango's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Polydextrose 7 references
  1. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
  2. Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. PubMed
  3. Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. PubMed
  4. Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258.
  5. Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. PubMed
  6. Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-contro
  7. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

See these in context on the Polydextrose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team