No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Hyaluronic Acid (Sodium Hyaluronate) Ingredients & Drug Interactions

by PureBulk.com

Hyaluronic Acid (Sodium Hyaluronate) label
See full label image
Powder Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hyaluronic Acid (Sodium Hyaluronate) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Hyaluronic Acid (Sodium Hyaluronate) is a dietary supplement by PureBulk.com with 1 active ingredient. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is pure hyaluronic acid (sodium hyaluronate) in powder form — just the one active ingredient with no fillers listed. Hyaluronic acid is a compound your body makes naturally; it helps skin hold water and is used both as a topical agent and as an oral supplement.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Hyaluronic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Hyaluronic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Dry eye — rated "Possibly Effective" (Natural Medicines).
  • On file: Venous leg ulcers — rated "Possibly Effective" (Natural Medicines).

Hyaluronic acid is rated possibly effective for dry eye and venous leg ulcers (slow-healing wounds in the legs tied to poor circulation). For aging skin, hay fever, and sexual dysfunction, the evidence in our data isn't established well enough to rate it.

If you're considering it for one of those latter uses, talk it over with your doctor about whether the research supports it for your situation.

The evidence, ingredient by ingredient Hyaluronic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally and topically, hyaluronic acid appears to be well tolerated overall. However, long-term safety of supplements hasn't been fully studied.

The product facts note that safety data for oral supplements is limited, and the caution is to avoid taking it by mouth unless your doctor advises you to. Topically, some people have reported eczema, redness, itching, and in rare cases wound bleeding or infection.

Eye drops containing hyaluronic acid have rarely caused eye pain. Avoid injection devices sold for cosmetic use — needle-free injectors have caused serious and sometimes permanent skin damage.

Side effects, ingredient by ingredient Hyaluronic Acid

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That doesn't mean none exist — if you take any prescription or over-the-counter medications, confirm with your own pharmacist before starting this product.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

Hyaluronic Acid may be worth considering if you have dry eye or a venous leg ulcer, since it's rated possibly effective for those. Because safety data for oral supplements is limited, talk with your doctor before taking it by mouth — they can advise whether it's right for you.

No interactions are documented for the ingredients we checked, but ask your pharmacist to confirm nothing unexpected comes up with your other medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hyaluronic Acid (Sodium Hyaluronate), straight from the product label.

Brand PureBulk.com
Net contents 10 g; 0.35 oz.
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 23121
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
100 mg
Maximum serving Sizes:
100 mg
Servings per container
100
IngredientAmount% DV
Hyaluronic Acid100 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Storage: Keep dry, cool & dark

Formulation

Free of: Sugar, soy, dairy, yeast, gluten, corn and additives.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 100 mg (1/16 tsp) twice daily, or as directed by physician.

General Statements

US Standard Measuring Spoons Spoon Size (level) milligrams 1/32 teaspoon 55 1/16 teaspoon 111 1/8 teaspoon 222

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult with your physician before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hyaluronic Acid (Sodium Hyaluronate) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size100 mg Dosage formPowder Servings per container100 Amounts shown are per serving.

Hyaluronic Acid

No known
interactions
100 mg per serving Form: Sodium Hyaluronate

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin...

Hyaluronic Acid monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Hyaluronic Acid (Sodium Hyaluronate). This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Hyaluronic Acid (Sodium Hyaluronate), from the product label.

PureBulk.com

See all PureBulk.com products
Name
PureBulk.com
City
Roseburg
State
OR
ZipCode
97471
Phone Number
(541) 679-1500
Web Address
PureBulk.com
Pharmacist Counseling Corner

Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com: Common Questions

Does Hyaluronic Acid (Sodium Hyaluronate) by PureBulk.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Hyaluronic Acid (Sodium Hyaluronate). This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Hyaluronic Acid (Sodium Hyaluronate) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
The product facts don't include pregnancy or breastfeeding safety data for hyaluronic acid. There isn't enough information on file to say either way. Talk with your doctor or pharmacist for personalized advice before taking it.
Will this help my skin look younger?
There isn't enough reliable evidence in our data to rate hyaluronic acid for aging skin. While it's used in many skincare products, we can't say whether the oral supplement works for that purpose based on what we hold.
What are the most common side effects?
Hyaluronic acid is generally well tolerated. When applied topically, some people have reported eczema, redness, itching, and rarely wound bleeding or infection. Eye drops containing it have rarely caused eye pain.
Is this the same hyaluronic acid used in injectable cosmetic treatments?
It's the same substance, but not the same use. Injectable devices sold for cosmetic purposes have caused serious and sometimes permanent damage to skin and eyes, so avoid needle-free injection devices. This powder is meant to be taken by mouth or used topically — not injected.
How does this powder work?
Hyaluronic acid is a compound your body makes naturally that helps skin and tissues retain water. As an oral supplement or topical product, it's meant to support hydration and skin health, though evidence is strongest for dry eye and venous leg ulcers.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Hyaluronic Acid (Sodium Hyaluronate) is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hyaluronic Acid (Sodium Hyaluronate) label
Go deeper

The Full Monographs Behind Hyaluronic Acid (Sodium Hyaluronate)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hyaluronic Acid

Hyaluronic acid is a natural substance in the body that helps hold water in the skin, joints, and eyes. Oral and topical products are popular for skin moisture and joint comfort, and the evi...

Read the full Hyaluronic Acid monograph →
Sources

Sources & How We Checked

Hyaluronic Acid (Sodium Hyaluronate)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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