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Dietary supplement

Khella Ingredients & Drug Interactions

by Herbalist & Alchemist

Khella label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Khella against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Khella is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for asthma and bronchitis, angina and heart-related chest pain, kidney stones.Based on those ingredients, 618 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried Khella seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Khella by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Khella by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Khella by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: dried khella seed extract. Khella (Ammi visnaga) is a Mediterranean plant traditionally used in herbal medicine, though modern evidence for its effectiveness remains limited.

The liquid is preserved with ethyl alcohol and distilled water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports respiratory function.
  • We looked for evidence on: asthma, bronchitis, airway function.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for khella is insufficient to rate it reliably for either of its traditional uses — psoriasis and vitiligo. While it has been studied for these skin conditions, the quality and quantity of evidence don't yet support a confident claim about whether it works.

If you're considering it for a skin condition, that's a conversation to have with your doctor or dermatologist alongside other proven options.

The evidence, ingredient by ingredient Khella

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Khella can cause side effects, especially with prolonged use or higher doses: nausea, dizziness, constipation, loss of appetite, headache, itching, and trouble sleeping. There's also concern it may cause sun sensitivity and can raise liver enzyme levels.

The safety data is limited, which is why it's not recommended during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Khella

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Khella.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 619 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking khella, double-check any photosensitizing drugs (like quinolone antibiotics, tetracyclines, sulfa antibiotics, and amitriptyline), medications that stress the liver (acetaminophen, amiodarone, carbamazepine, isoniazid, methotrexate, and others), and heart medications like digoxin. All carry Moderate interaction severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Khella is best considered only if you've exhausted other options for psoriasis or vitiligo and have discussed it with your doctor. Avoid it entirely if you're pregnant, nursing, or taking heart, antibiotic, seizure, tuberculosis, or liver-sensitive medications.

Run your medication list through the interaction checker before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Khella, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056134754
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 179835
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Khella by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
1 mL
Servings per container
60
UPC/BARCODE
667056134754
IngredientAmount% DV
dried Khella seed extract1 mL--

Other ingredients: distilled Water, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Ammi visnaga

OK

General Statements

Supports Respiratory Function

Botanical Preparation Ratio 1:4

FDA Statement of Identity

Herbal Supplement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: 10-20 drops (0.5-1 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Contraindications: May cause photosensitivity in fair-skinned individuals.

Keep out of children's reach

General

NO. KLA-2 1743MO

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Khella by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Khella label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Khella by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Dried Khella seed extract

Interacts with
618 drugs
1 mL per serving

Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels. While it has...

Dried Khella seed extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Khella by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Khella?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
618Drugs
618 Moderate

Ingredients driving the most interactions

dried Khella seed extract 618

Individual Drug Interactions

The ingredients in Khella interact with 618 drugs. Click any drug to see the details.

1 of the 1 ingredient in Khella interact with drugs. Each result below shows which ingredient is responsible. dried Khella seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Khella with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

dried Khella seed extract3 drug types · 618 drugs

Digoxin (Lanoxin)

Theoretically, khella might decrease the effectiveness of cardiac glycosides like digoxin. The khella constituent visnadin has negative inotropic effects that might counter the effects of cardiac glycosides.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, khella might have additive adverse effects on the liver when used with hepatotoxic drugs. Khella can increase liver transaminases. Some drugs that can adversely affect the liver include acetaminophen (Tylenol), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), and many others.

Likelihood Possible Evidence B
Photosensitizing Drugs

Theoretically, concomitant use might result in increased photosensitivity. Khella constituents can cause photosensitivity. Some drugs that cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.

Likelihood Possible Evidence D
dried Khella seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Khella, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Khella by Herbalist & Alchemist: Common Questions

Does Khella by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Khella has a known interaction with 618 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Khella contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take khella if I'm on antibiotics?
Not safely with certain ones. If you're taking quinolones (like Cipro), tetracyclines, or sulfa antibiotics (like Bactrim), khella may increase sun sensitivity and raise your risk of severe sunburn. Talk to your pharmacist about your specific antibiotic before starting khella.
What are the most common side effects?
Nausea, dizziness, headache, and constipation happen with regular or high-dose use. There's also a risk of sun sensitivity and elevated liver enzymes. If you notice any of these, stop and talk to your pharmacist.
Is khella safe during pregnancy or breastfeeding?
No. The safety data advises against khella during pregnancy and while breastfeeding. If you're considering it and pregnant or nursing, talk with your doctor or pharmacist first.
Does khella actually work for psoriasis or vitiligo?
The evidence isn't strong enough yet to say reliably. While khella has been used traditionally and studied for these conditions, we don't have solid proof it works. Your dermatologist can discuss whether it's worth trying alongside established treatments.
Will this interact with my heart medication?
If you take digoxin (Lanoxin), yes — khella may make it less effective. More broadly, khella can stress the liver, so if your heart medication also affects liver function, the combination carries risk. Check your exact drug with the tool on this page.
What are the inactive ingredients?
The liquid contains ethyl alcohol and distilled water as preservatives and base. If you avoid alcohol, this product isn't for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Khella label
Go deeper

The Full Monographs Behind Khella’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Khella

Interacts with 618 drugs

Khella is a Mediterranean herb whose seeds contain compounds like khellin that may relax smooth muscle in the airways and blood vessels. While it has a long history of traditional use for br...

Read the full Khella monograph →
Sources

Sources & How We Checked

Khella's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Khella 10 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Abdel-Fattah A, Aboul-Enein MN, Wassel GM, El-Menshawi BS. An approach to the treatment of vitiligo by khellin. Dermatologica 1982;165:136-40. PubMed
  4. Duarte J, Torres AI, Zarzuelo A. Cardiovascular effects of visnagin on rats. Planta Med 2000;66:35-9. PubMed
  5. Abdel-Fattah A, Aboul-Enein MN, Wassel G, El-Menshawi B. Preliminary report on the therapeutic effect of khellin in psoriasis. Dermatologica 1983;167:109-10. PubMed
  6. Ossenkoppele PM, van der Sluis WG, van Vloten WA. [Phototoxic dermatitis following the use of Ammi majus fruit for vitiligo]. Ned Tijdschr Geneeskd 1991;135:478-80.
  7. Harvengt C, Desager JP. HDL-cholesterol increase in normolipaemic subjects on khellin: a pilot study. Int J Clin Pharmacol Res 1983;3:363-6.
  8. Dr. Duke's Phytochemical and Ethnobotanical Databases. Available at: http://www.ars-grin.gov/duke/.
  9. de Leeuw J, van der BN, Maierhofer G, et al. A case study to evaluate the treatment of vitiligo with khellin encapsulated in L-phenylalanin stabilized phosphatidylcholine liposomes in combination with ultraviolet light therapy. Eur J Dermatol 2003;13(5):
  10. Orecchia G, Perfetti L. Photochemotherapy with topical khellin and sunlight in vitiligo. Dermatology 1992;184(2):120-123. PubMed

See these in context on the Khella monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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