No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Histidine 500 mg Capsules Ingredients & Drug Interactions

by BulkSupplements.com

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Histidine 500 mg Capsules is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Histidine 500 mg Capsules by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-histidine, an amino acid your body needs for a range of functions. The capsule itself is made from bovine gelatin, an inactive ingredient that holds the powder inside.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Histidine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Histidine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cholera — rated "Possibly Effective" (Natural Medicines).

The evidence for L-histidine varies by condition. It's possibly effective for cholera.

For atopic dermatitis (eczema), kidney failure, and rheumatoid arthritis (RA), the evidence we hold rates as insufficient — meaning there isn't enough reliable research to say whether it works for those uses.

The evidence, ingredient by ingredient Histidine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-histidine from food is considered likely safe as part of normal nutrition. However, the safety of higher supplement doses like the ones in this product isn't well established.

The research we have is limited, so caution is advised unless a doctor has recommended it to you. For pregnancy and lactation, L-histidine is rated as likely safe.

That said, you should confirm with your doctor or pharmacist before starting any supplement when you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Histidine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-histidine. Still, check your specific medications using the tool on this page to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.

This product is a single-ingredient amino acid supplement with no documented medication interactions in our data. It may be worth considering if a healthcare provider has recommended it for a specific reason — but because safety data on supplement doses is limited, talk to your pharmacist before you start, especially if you're pregnant, breastfeeding, or taking medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Histidine 500 mg Capsules, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X003L0CZCN
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 312916
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Histidine 500 mg Capsules by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
X003L0CZCN
IngredientAmount% DV
L-Histidine500 mg--

Other ingredients: Bovine Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

L-Histidine Capsules 500 mg per serving

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 capsule once daily, or as directed by a physician.

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Always consult a physician before taking any dietary supplement.

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Precautions

Keep out of reach of children.

Storage

Store in a dry, cool place

General Statements

New Scan Me

See for yourself

L-Histidine 500 mg Capsules by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Histidine 500 mg Capsules by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

L-Histidine

No known
interactions
500 mg per serving

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...

L-Histidine monograph & interactions

Other (inactive) ingredients: Bovine Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Histidine 500 mg Capsules by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Histidine 500 mg Capsules. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Histidine 500 mg Capsules, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Histidine 500 mg Capsules by BulkSupplements.com: Common Questions

Does L-Histidine 500 mg Capsules by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Histidine 500 mg Capsules. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Histidine 500 mg Capsules contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-histidine safe during pregnancy or while breastfeeding?
L-histidine is rated as likely safe during pregnancy and lactation. Even so, it's smart to check with your doctor or pharmacist before starting any supplement when you're expecting or nursing — they know your full health picture.
What is L-histidine, and what does it do?
L-histidine is an amino acid — one of the building blocks your body uses for protein and other important functions. It's present in protein-containing foods, but this supplement provides it in concentrated form.
Does this product actually work?
The evidence depends on what you're taking it for. It's possibly effective for cholera. For eczema, kidney failure, and rheumatoid arthritis, the research we hold is insufficient to say whether it works — there just isn't enough reliable data yet.
Are there any side effects from L-histidine supplements?
No adverse effects are listed in the data we hold. That said, the safety of supplement doses isn't well studied compared to food amounts, so caution is advised unless your doctor recommended it.
Does this supplement interact with medications?
No interactions are documented in our data for L-histidine. That doesn't guarantee none exist — it means we hold no research showing them. Use the medication checker on this page with your exact drug names to be sure.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Histidine 500 mg Capsules is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Histidine 500 mg Capsules label
Go deeper

The Full Monographs Behind L-Histidine 500 mg Capsules’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Histidine 500 mg Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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