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Dietary supplement

L-Lysine Monolaurin 1:1 Ratio Ingredients & Drug Interactions

by Solaray

Capsule Category: Other Combinations
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

L-Lysine Monolaurin 1:1 Ratio is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for cold sores (herpes labialis), genital herpes outbreaks, supporting protein and collagen formation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated minor. The ingredients most likely to interact are L-Lysine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Lysine Monolaurin 1:1 Ratio by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients in a 1:1 ratio: L-lysine hydrochloride and monolaurin. L-lysine is an amino acid (a building block your body uses to make protein), while monolaurin is a fatty acid derived from coconut and palm oils.

The capsule also contains cellulose, silica, and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Immune support.
  • We looked for evidence on: Herpes labialis (cold sores), viral infections, cold sores, herpes support.
  • The strongest evidence on file: Lysine is rated "Possibly Effective" for Herpes labialis (cold sores) (Natural Medicines).

The evidence we hold shows L-lysine is possibly effective for herpes labialis (cold sores) — meaning some clinical research supports it, but more high-quality studies are needed. For child growth, pressure ulcers, and diabetic foot ulcers, we have insufficient evidence to rate L-lysine.

Monolaurin's effectiveness for bacterial vaginosis has not been established in the data we hold.

The evidence, ingredient by ingredient Lysine Monolaurin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-lysine is generally well tolerated at typical doses, though high amounts may cause stomach upset (abdominal pain, diarrhea, or indigestion). Long-term safety isn't well studied.

One case report linked very high-dose oral lysine to a kidney inflammation, but this is rare. Lysine from food is fine; supplement use in pregnancy isn't well studied, so check with your doctor first.

There isn't enough data on supplement use while breastfeeding either. Monolaurin is often well tolerated in food-related amounts, but supplement safety in humans hasn't been well studied.

The safety data advises against use during pregnancy. While lauric acid (what monolaurin is made from) occurs naturally in breast milk, monolaurin supplement safety while breastfeeding is unknown — use caution and talk to your doctor.

Side effects, ingredient by ingredient Lysine Monolaurin

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lysine.
  • The most serious interaction on file is rated Minor.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take 5-HT4 agonists (medications for certain gut disorders), double-check with your pharmacist before adding this product — L-lysine may reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product may be worth considering if you get cold sores and want to try L-lysine, since there's some evidence it helps. If you take any medications for gut disorders or are pregnant or breastfeeding, talk to your pharmacist or doctor first before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Lysine Monolaurin 1:1 Ratio, straight from the product label.

Brand Solaray
Barcode (UPC) 076280352818
Net contents 60 VegCap(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 326039
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Lysine Monolaurin 1:1 Ratio by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 VegCap(s)
Maximum serving Sizes:
2 VegCap(s)
Servings per container
30
UPC/BARCODE
076280352818
IngredientAmount% DV
L-Lysine Hydrochloride500 mg--
Monolaurin500 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Solaray Est. 1973 A Brighter Way 1973

Formulation

Immune Support

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Lab Verified

General Statements

Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.

100% PCR Bottles

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take 2 VegCap daily with a meal or glass of water.

Storage

Store in a cool, dry place.

Formula

Discussion: L-Lysine is an amino acid produced naturally by a microbiological fermentation process and is an essential component of protein found naturally in the human body. Monolaurin is a mono-ester of lauric acid, a fatty acid found in coconut oil and present in breast milk. They have been studied for their reputed ability to provide nutritive support for the immune system.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

L-Lysine Monolaurin 1:1 Ratio by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Lysine Monolaurin 1:1 Ratio by Solaray

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 VegCap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Lysine Hydrochloride

Interacts with
1 drug
500 mg per serving

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to t...

L-Lysine Hydrochloride monograph & interactions

Monolaurin

No known
interactions
500 mg per serving Form: Glyceryl Monolaurate

Monolaurin is a compound made from lauric acid, a fatty acid found in coconut oil and breast milk, and it is marketed mostly for immune and antimicrob...

Monolaurin monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Lysine Monolaurin 1:1 Ratio by Solaray Drug Interactions

Want to check YOUR meds against L-Lysine Monolaurin 1:1 Ratio?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1Drugs
1 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Lysine Monolaurin 1:1 Ratio with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for L-Lysine Monolaurin 1:1 Ratio, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutraceutical.com
Pharmacist Counseling Corner

L-Lysine Monolaurin 1:1 Ratio by Solaray: Common Questions

Does L-Lysine Monolaurin 1:1 Ratio by Solaray interact with any medications?
Yes. Based on its ingredients, L-Lysine Monolaurin 1:1 Ratio has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Lysine Monolaurin 1:1 Ratio contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-lysine actually help with cold sores?
The evidence says possibly effective — some clinical research supports it, but we need more high-quality studies to be sure. It's worth trying if you're prone to them, but results vary person to person.
What side effects should I watch for?
L-lysine may cause stomach upset, diarrhea, abdominal pain, or indigestion, especially at high doses. Monolaurin has no adverse effects documented in our data, but its supplement safety overall hasn't been well studied in humans.
Is it safe to take while pregnant?
Not without talking to your doctor first. L-lysine from food is fine, but supplement safety in pregnancy isn't well studied. Monolaurin should be avoided during pregnancy based on the safety data.
Can I take it while breastfeeding?
You should talk to your doctor. There isn't enough data on L-lysine supplement use while breastfeeding, and while lauric acid occurs naturally in breast milk, monolaurin supplement safety during breastfeeding is unknown.
What are L-lysine and monolaurin?
L-lysine is an amino acid your body uses to build protein. Monolaurin is a fatty acid derived from coconut and palm oils. Together they're meant to work as a 1:1 combination in this capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Lysine Monolaurin 1:1 Ratio is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Lysine Monolaurin 1:1 Ratio label
Sources

Sources & How We Checked

L-Lysine Monolaurin 1:1 Ratio's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Monolaurin 2 references
  1. FDA, Center for Food Safety and Applied Nutrition, Office of Premarket Approval, EAFUS: A food additive database. Website: vm.cfsan.fda.gov/~dms/eafus.html (Accessed 23 February 2006).
  2. Mancuso AC, Widdice LE, Hughes BL, et al. Five Percent Monolaurin Vaginal Gel for the Treatment of Bacterial Vaginosis: A Randomized Placebo-Controlled Trial. J Low Genit Tract Dis. 2020 Jul;24(3):277-283. PubMed

See these in context on the Monolaurin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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