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Dietary supplement

L-Methionine 500 mg Ingredients & Drug Interactions

by Bluebonnet

L-Methionine 500 mg label
See full label image
Capsule Category: Amino Acid/protein
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Methionine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

L-Methionine 500 mg is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of L-Methionine 500 mg by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-methionine, an amino acid your body uses to build proteins and make other important molecules. Each capsule delivers 500 mg.

The capsules themselves are vegetable-based, and the inactive ingredients — magnesium stearate and silica — are standard binders and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Methionine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Methionine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Neural tube birth defects — rated "Possibly Effective" (Natural Medicines).

L-methionine has possibly effective evidence for reducing the risk of neural tube birth defects — the kind of defect that affects the brain and spinal cord during fetal development. For acetaminophen poisoning, hay fever, asthma, and colorectal cancer, the evidence we hold is insufficient to rate whether it works.

These gaps don't mean it doesn't help; it means the research isn't solid enough yet for us to say.

The evidence, ingredient by ingredient Methionine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When you eat methionine in food amounts, it's well tolerated. High-dose supplements, though, may cause side effects — dizziness, drowsiness, low blood pressure, irritability, vomiting, headache, and in rare cases more serious problems — so they should be used with medical guidance.

The data shows normal dietary amounts are fine during pregnancy and breastfeeding, but supplement doses during these times haven't been proven safe, so talk with your doctor or pharmacist about whether this dose is right for you if you're pregnant or nursing.

Side effects, ingredient by ingredient Methionine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-methionine. That doesn't guarantee none exist, so check your exact medications with your doctor or pharmacist before starting.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

L-methionine might be worth considering if you're interested in neural tube defect prevention and your doctor agrees, but the evidence for other uses is still being studied. Because this is a high-dose supplement, discuss it with your doctor or pharmacist before you start — especially if you're pregnant, breastfeeding, or have concerns about homocysteine or blood pressure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Methionine 500 mg, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715000605
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279553
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Methionine 500 mg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
743715000605
IngredientAmount% DV
L-Methionine500 mg--

Other ingredients: Kosher Vegetable Capsules, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.

Formula

Bluebonnet's L-Methionine 500 mg Capsules contain the pharmaceutical grade, free-form amino acid L-methionine in its purest crystalline form from Ajinomoto.

K Parve (Kosher)

Bluebonnet's KOF-K Certification #K-0000700

Formulation

Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption.

Free-form amino acid

Vegan

Gluten free

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat and soybeans. Also free of corn, yeast, gluten, barley, rice, sodium and sugar.

Precautions

Caution: For adults only.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Seals/Symbols

Made with non GMO ingredients

AjiPure Amino Acids

K Parve (Kosher)

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Methionine 500 mg by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Methionine 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Methionine 500 mg by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

L-Methionine

No known
interactions
500 mg per serving

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...

L-Methionine monograph & interactions

Other (inactive) ingredients: Kosher Vegetable Capsules, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Methionine 500 mg by Bluebonnet Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Methionine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Methionine 500 mg, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
Texas
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

L-Methionine 500 mg by Bluebonnet: Common Questions

Does L-Methionine 500 mg by Bluebonnet interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Methionine 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Methionine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-methionine safe to take while pregnant?
Food amounts of methionine are fine during pregnancy. Supplement doses like this one, though, haven't been proven safe in pregnancy. Talk with your doctor or pharmacist — they can help you decide if this product is right for you based on your individual situation.
What are the most common side effects?
When methionine is taken by mouth in food amounts, it's well tolerated. At supplement doses, the most common side effects can include dizziness, drowsiness, low blood pressure, irritability, headache, and vomiting. Serious side effects are rare.
Can this help prevent birth defects?
L-methionine has possibly effective evidence for reducing the risk of neural tube birth defects. If you're considering it for this reason during pregnancy or if you're planning pregnancy, talk with your doctor first.
What does methionine do in the body?
Methionine is an amino acid — one of the building blocks your body uses to make proteins and other important molecules. It plays a role in many body processes, including ones related to fetal development.
Are there any fillers in these capsules?
The capsules are vegetable-based and contain magnesium stearate and silica as inactive ingredients — these are standard binders and flow agents that help the supplement hold together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Methionine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Methionine 500 mg label
Go deeper

The Full Monographs Behind L-Methionine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph →
Sources

Sources & How We Checked

L-Methionine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Methionine 12 references
  1. La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
  2. Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
  3. Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
  4. Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
  5. Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
  6. McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
  10. Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
  11. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
  12. Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed

See these in context on the Methionine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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