No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Ornithine 500 mg Ingredients & Drug Interactions

by Bluebonnet

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Ornithine 500 mg is a dietary supplement by Bluebonnet with 1 active ingredient. Its ingredients are commonly taken for athletic performance and recovery, reducing fatigue, sleep and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Ornithine 500 mg by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Ornithine Hydrochloride at 500 mg per capsule. Ornithine is an amino acid your body makes naturally and can also obtain from protein-rich foods.

The capsule itself is made from cellulose and hypromellose (plant-based materials), with small amounts of purified water, magnesium stearate, and silicon dioxide as inactive ingredients to help with manufacturing and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: nitric oxide synthesis and men's health performance.
  • We looked for evidence on: Athletic performance, Wound healing, Erectile function, Muscle recovery, Endothelial function.
  • The strongest evidence on file: Ornithine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Ornithine is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence for L-Ornithine is mixed depending on what you're using it for. It's rated possibly effective for athletic performance — meaning there's some research suggesting it may help, but the evidence isn't yet solid enough to be certain.

For dry skin, insomnia, and periodontitis (gum inflammation), the evidence we hold is insufficient to say whether it works or not. If you're considering this for one of those other uses, talk with your pharmacist about what the current science shows.

The evidence, ingredient by ingredient Ornithine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Ornithine is generally well tolerated when used short-term. However, long-term safety hasn't been well studied, so we don't have solid data on what happens if you take it for months or years on end.

The safety data advises against use during pregnancy and while breastfeeding due to lack of adequate safety information. If you're pregnant, breastfeeding, or planning either, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Ornithine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-Ornithine Hydrochloride. That doesn't mean none could occur in your individual situation, so mention this supplement to your pharmacist when filling any new prescriptions — they can flag any concerns specific to your medications.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and some safety-information gaps remain.

L-Ornithine may be worth considering if you're looking at athletic performance support and want an ingredient with a possibly effective rating. Because long-term safety isn't well established and pregnancy/breastfeeding safety data is limited, anyone in those categories should check with their pharmacist first.

No medication interactions are documented for this ingredient.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Ornithine 500 mg, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715000704
Net contents 100 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 316408
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, No Allergies, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Ornithine 500 mg by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
743715000704
IngredientAmount% DV
L-Ornithine Hydrochloride500 mg--

Other ingredients: Cellulose, Hypromellose, Water, Purified, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Bluebonnet's L-Ornithine 500mg Vegetable Capsules are formulated with the free-form amino acid L-ornithine HCl to help support nitric oxide synthesis and men's health/performance.

Bluebonnet's KOF-K Certification #K-0000700

K Parve (Kosher)

Formulation

May support nitric oxide synthesis

Free of milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans and sesame. Also free of corn, gluten, barley, rice, sodium and sugar.

Made with non GMO ingredients Gluten free

Nitric oxide synthesis

V Vegan

Precautions

Caution: For adults only. Keep out of reach of children.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made with non GMO ingredients V Vegan K Parve (Kosher)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily or as directed by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

See for yourself

L-Ornithine 500 mg by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Ornithine 500 mg by Bluebonnet

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

L-Ornithine Hydrochloride

No known
interactions
500 mg per serving

Ornithine is a non-essential amino acid your body makes naturally as part of the urea cycle, which helps remove ammonia. It is sold as a supplement fo...

L-Ornithine Hydrochloride monograph & interactions

Other (inactive) ingredients: Cellulose, Hypromellose, Water, Purified, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Ornithine 500 mg by Bluebonnet Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Ornithine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Ornithine 500 mg, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
bluebonnetnutrition.com
Pharmacist Counseling Corner

L-Ornithine 500 mg by Bluebonnet: Common Questions

Does L-Ornithine 500 mg by Bluebonnet interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Ornithine 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Ornithine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does L-Ornithine actually work for athletic performance?
The evidence is rated possibly effective, meaning there's some research suggesting it may help, but we can't say for certain yet. If you're an athlete considering it, your best bet is to talk with a sports nutritionist or your doctor about whether the current evidence fits your goals.
Is this safe to take long-term?
L-Ornithine is generally well tolerated short-term, but long-term safety hasn't been well studied. If you're thinking about taking it for several months or more, check with your pharmacist to weigh what we know and don't know.
Can I take this while pregnant or breastfeeding?
The safety data advises against it — there isn't enough information to know it's safe in either situation. Talk with your doctor or pharmacist about your specific circumstances before using it.
What's in the capsule besides the active ingredient?
The capsule is made from cellulose and hypromellose, with small amounts of purified water, magnesium stearate, and silicon dioxide to help with manufacturing. No other active ingredients are in here.
Will this interact with my blood pressure medication (or other drugs)?
No interactions are documented in our data for L-Ornithine, but absence of documented interactions isn't a guarantee none exist. Use the checker on this page with your specific medications, or ask your pharmacist — they know your full medication list best.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Ornithine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Ornithine 500 mg label
Go deeper

The Full Monographs Behind L-Ornithine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Ornithine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ornithine 1 reference
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Ornithine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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