L-Serine 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking L-Serine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Serine 500 mg is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of L-Serine 500 mg by Douglas Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-serine, a 500 mg dose per capsule. L-serine is an amino acid — one of the building blocks your body uses to make protein and other compounds.
The capsule itself is made from gelatin and filled out with microcrystalline cellulose, vegetable stearate, and magnesium silicate, which are inert fillers and binders.
Does it work?
Moderate evidence
The evidence is mixed. L-serine is rated possibly effective for schizophrenia, meaning there's some promising research but not enough to be certain.
For Alzheimer disease, amyotrophic lateral sclerosis (ALS, a degenerative nerve disease), back pain, post-traumatic stress disorder (PTSD), and cognitive function, the evidence we hold is insufficient to say whether it works or not. If you're considering this for any of those conditions, talk with your doctor about whether the current research supports it for your specific situation.
How safe is it?
Well-documented data
L-serine from food sources is generally well tolerated, but supplement safety and long-term use haven't been thoroughly studied. The most common side effects at higher doses are stomach upset — abdominal pain, bloating, indigestion, loss of appetite, and nausea.
These are dose-dependent, meaning higher amounts are more likely to cause them. Rarely, very high doses (above 25 grams daily) have been reported to cause reversible eye twitching (nystagmus) and seizures.
There isn't enough safety data on L-serine supplements during pregnancy, so it's best avoided unless your doctor advises otherwise. Safety during breastfeeding hasn't been studied, so the same caution applies.
Meds to double-check
No known interactions
No interactions are documented for L-serine in our data. That means we don't hold medication-specific warnings for this ingredient — but it's always worth mentioning any new supplement to your doctor or pharmacist, especially if you're on multiple medications or have a complex health history.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
L-serine may be worth considering if you're exploring options for schizophrenia under your doctor's guidance, though the evidence is still emerging. For other uses like cognitive support or PTSD, the research is too early to say whether it'll help you.
Since long-term safety data is limited and stomach upset is possible at higher doses, talk with your doctor or pharmacist about whether this makes sense for you and what dose to try.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Serine 500 mg, straight from the product label.
| Brand | Douglas Laboratories |
|---|---|
| Barcode (UPC) | 310539018422 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 232179 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Serine 500 mg by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Serine | 500 mg | -- |
Other ingredients: Microcrystalline Cellulose, Gelatin, Vegetable Stearate, Magnesium Silicate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: As a dietary supplement, adults take 1 capsule daily or as directed by your healthcare professional.
Precautions
Warning: If you are pregnant, nursing, have any health condition or taking any medication, consult your health professional before using this product.
Keep out of the reach of children.
Use only if safety seal is intact.
Storage
Store in a cool, dry place.
Formulation
Gluten-free, Non-GMO
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our manufacturing excellence
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Serine 500 mg by Douglas Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Serine 500 mg by Douglas Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-Serine
No knowninteractions
Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...
L-Serine monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Vegetable Stearate, Magnesium Silicate. These complete the product’s ingredient list but are not active constituents.
L-Serine 500 mg by Douglas Laboratories Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in L-Serine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for L-Serine 500 mg, from the product label.
Douglas Laboratories
See all Douglas Laboratories products- Name
- Douglas Laboratories
- Street Address
- 600 Boyce Road
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15205
- Phone Number
- 1.800.245.4440
- Web Address
- www.douglaslabs.com
L-Serine 500 mg by Douglas Laboratories: Common Questions
Does L-Serine 500 mg by Douglas Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is L-serine and what does it do in the body?
Will this upset my stomach?
Can I take this if I'm pregnant or breastfeeding?
Is this proven to work for memory or brain health?
Does this interact with any medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Serine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Serine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Serine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 3 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Serine 3 references
- Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
- Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
- Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC