No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Serine 500 mg Ingredients & Drug Interactions

by Nutricost

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Serine 500 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Serine 500 mg by Nutricost

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-serine, an amino acid (a building block protein). Each capsule delivers 500 mg.

The capsule itself and the other ingredients — hypromellose, rice flour, stearic acid, and silicon dioxide — are inactive fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Serine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Serine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Schizophrenia — rated "Possibly Effective" (Natural Medicines).

L-serine shows some promise for schizophrenia and is rated possibly effective for that use. For Alzheimer's disease, ALS (Lou Gehrig's disease), back pain, PTSD, and cognitive function in general, the evidence isn't yet established — we have insufficient reliable data to rate it one way or the other.

The evidence, ingredient by ingredient Serine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-serine is generally well tolerated in the doses used in studies, though long-term safety and supplement safety in general aren't fully established. The most common side effects are gastrointestinal — stomach upset, bloating, heartburn, nausea, or loss of appetite.

High doses (well above what's in this product) have rarely caused seizures. There isn't enough safety data to support L-serine in pregnancy; the safety data on breastfeeding hasn't been studied at all.

Talk with your doctor or pharmacist before taking it if you're pregnant or nursing.

Side effects, ingredient by ingredient Serine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for L-serine in our data. That said, confirm with your own doctor or pharmacist before combining it with any medications, especially if you have a seizure disorder or take seizure medications.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

This is a straightforward single-ingredient supplement for people interested in amino acid support, particularly those curious about schizophrenia research. Because evidence for other uses is still unclear, be clear on what you're hoping it will do.

If you're pregnant, nursing, or have questions about whether it fits your health picture, check with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Serine 500 mg, straight from the product label.

Brand Nutricost
Barcode (UPC) 810014671321
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 272671
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Serine 500 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
810014671321
IngredientAmount% DV
L-Serine500 mg--

Other ingredients: Hypromellose, Rice Flour, Stearic Acid, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 1 capsule daily with 8-12 oz of water or as directed by your healthcare professional.

Precautions

Warning: For healthy individuals 18 years and older.

Consult a healthcare professional prior to use if you are pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if safety seal is broken or missing.

Storage

Notice: Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Quality Guaranteed Nutricost

Formulation

Vegetarian Product

Non GMO Gluten Free Product

Formula

L-Serine 500 mg per serving

See for yourself

L-Serine 500 mg by Nutricost label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Serine 500 mg by Nutricost

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

L-Serine

No known
interactions
500 mg per serving

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...

L-Serine monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Flour, Stearic Acid, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Serine 500 mg by Nutricost Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Serine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Serine 500 mg, from the product label.

Nutricost

See all Nutricost products
Name
Nutricost
Street Address
351 E 1750 N
City
Vineyard
State
UT
ZipCode
84058
Phone Number
(866) 438-3694
Web Address
www.nutricost.com
Pharmacist Counseling Corner

L-Serine 500 mg by Nutricost: Common Questions

Does L-Serine 500 mg by Nutricost interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Serine 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Serine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-serine?
L-serine is an amino acid — one of the building blocks your body uses to make protein. You get it naturally from food, but this supplement delivers a concentrated dose (500 mg per capsule) in addition to what you eat.
Does L-serine work for Alzheimer's disease or dementia?
We don't have enough reliable evidence yet to say whether it works. The research is incomplete, so we can't rate its effectiveness for those conditions.
What are the side effects?
Most people tolerate it well, but stomach upset — bloating, nausea, heartburn, or loss of appetite — is the most common issue. Higher doses than what's in this capsule have rarely caused seizures, but that's not a concern at 500 mg.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data to know. The facts advise against it unless your doctor says it's okay. If you're pregnant or nursing, talk with your doctor or pharmacist first.
Can I take this with my other medications?
We have no documented interactions, but that doesn't guarantee none exist. Check your specific medications with the interaction tool on this page, or confirm with your own doctor or pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Serine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Serine 500 mg label
Go deeper

The Full Monographs Behind L-Serine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Serine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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