No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

L-Serine Ingredients & Drug Interactions

by BulkSupplements.com

Powder Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

L-Serine is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for memory and brain health, nervous system disorders (e.g., als research), mood and stress support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of L-Serine by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-serine, an amino acid your body uses to build proteins and support nerve and brain function. BulkSupplements.com's version is a powder with no other added inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Serine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Serine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Schizophrenia — rated "Possibly Effective" (Natural Medicines).

The evidence is mixed. L-serine is possibly effective for schizophrenia based on available data.

For Alzheimer disease, amyotrophic lateral sclerosis (ALS), back pain, post-traumatic stress disorder (PTSD), and cognitive function, we don't yet have enough reliable evidence to say whether it works. If you're considering it for one of those other uses, talk it over with your doctor about what the current research actually shows.

The evidence, ingredient by ingredient Serine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-serine taken by mouth is generally well tolerated in the amounts used in studies, though side effects tend to be dose-dependent. The most common ones are gastrointestinal—stomach pain, bloating, indigestion, nausea, and loss of appetite.

At very high doses (above 25 grams daily), rare serious effects like reversible eye-movement problems (nystagmus) and seizures have been reported. During pregnancy, there isn't enough safety data on supplemental serine, so it's best avoided unless your doctor specifically advises it.

The same goes for breastfeeding—safety hasn't been studied, so skip it unless directed by your doctor.

Side effects, ingredient by ingredient Serine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No medication interactions are documented for L-serine in our data. Still, run your specific medications through the interaction checker below before you begin, and let your doctor or pharmacist know you're taking it.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

L-serine may be worth considering if you're exploring options for schizophrenia, though talk that over with your doctor first. For other uses like cognitive support or PTSD, the evidence isn't there yet.

No drug interactions are on file, but start at a low dose to see how your stomach handles it—gastrointestinal upset is the main side effect most people notice. Check with your doctor or pharmacist before starting, especially if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Serine, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000L7Q6E7
Net contents 1 kg; 35.3 Ounce(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 254752
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Serine by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2000 Milligram(s)
Maximum serving Sizes:
2000 Milligram(s)
Servings per container
500
UPC/BARCODE
X000L7Q6E7
IngredientAmount% DV
L-Serine2000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & pure bulk supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 2000 mg (about 3/4 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

See for yourself

L-Serine by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Serine by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2000 Milligram(s) Dosage formPowder Servings per container500 Amounts shown are per serving.

L-Serine

No known
interactions
2000 mg per serving

Serine is an amino acid your body can make on its own and also gets from protein-rich foods, so most people do not need a supplement. L-serine has bee...

L-Serine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Serine by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in L-Serine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for L-Serine, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Serine by BulkSupplements.com: Common Questions

Does L-Serine by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in L-Serine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
L-Serine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-serine used for?
L-serine is an amino acid your body uses to build proteins and support nerve and brain function. The evidence is strongest for schizophrenia (possibly effective). For conditions like Alzheimer disease, ALS, back pain, PTSD, and general cognitive function, we don't have enough reliable data yet to say whether it works.
What are the most common side effects?
The most common side effects are gastrointestinal: stomach pain, bloating, indigestion, nausea, and loss of appetite. These tend to be dose-dependent, so starting low and building up may help. At very high doses (above 25 grams daily), rare serious effects like seizures have been reported.
Is it safe to take during pregnancy?
No. There isn't enough safety data on supplemental serine in pregnancy, so it's best avoided unless your doctor specifically advises it.
Is it safe while breastfeeding?
Safety during breastfeeding hasn't been studied, so avoid this supplement unless your doctor directs you to take it.
Does L-serine interact with medications?
No interactions are documented in our data for L-serine. That doesn't guarantee none exist, though, so it's still a good idea to check with your doctor or pharmacist before you start, especially if you take prescription medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Serine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Serine label
Go deeper

The Full Monographs Behind L-Serine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Serine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serine 3 references
  1. Fridman V, Suriyanarayanan S, Novak P, et al. Randomized trial of l-serine in patients with hereditary sensory and autonomic neuropathy type 1. Neurology. 2019;92(4):e359-e370.
  2. Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010 Aug;121(1-3):125-30. PubMed
  3. Levine TD, Miller RG, Bradley WG, et al. Phase I clinical trial of safety of L-serine for ALS patients. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(1-2):107-111. PubMed

See these in context on the Serine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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