Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Lipase-HP Plus Ingredients & Drug Interactions

by AST Enzymes

Lipase-HP Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lipase-HP Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lipase-HP Plus is a dietary supplement by AST Enzymes with 5 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Amla. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lipase-HP Plus by AST Enzymes

Ask about any prescription or over-the-counter medication and we check it for interactions with Lipase-HP Plus by AST Enzymes — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lipase-HP Plus by AST Enzymes

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.

Lipase-HP Plus contains 5 active ingredients: lipase, amla (Indian gooseberry), proteases, amylases, and bovine bile. These are all digestive enzymes and bile components intended to support fat and protein breakdown in your digestive tract.

The product also includes inactive ingredients — cellulose, maltodextrin, and silica — which are fillers and capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: fat digestion and gallbladder function support.
  • We looked for evidence on: Dyspepsia, Fat malabsorption, Pancreatic insufficiency, Postprandial bloating.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence for these ingredients is mixed. Lipase and proteases haven't yet been rated for effectiveness — the research isn't established in our data.

Amla shows more promise: it's rated possibly effective for acid reflux (GERD) and high cholesterol (dyslipidemia). For other uses like low cholesterol overall, hair loss, and digestive upset, the evidence is insufficient to rate.

If you're taking this for digestive support, talk with your pharmacist about what the science actually supports.

The evidence, ingredient by ingredient Lipase Indian Gooseberry Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lipase is generally well tolerated, though people with serious digestive conditions should use it only under medical guidance. No adverse effects have been reported in adults in typical use, but safety testing hasn't been thorough.

Amla is generally well tolerated as a food, but supplement safety is less studied. A small number of trial participants reported stomach discomfort, fatigue, or muscle pain.

Proteases are generally well tolerated but may occasionally cause digestive upset or allergic reactions — rare occupational exposure to airborne protease has triggered allergic rhinitis or asthma. In pregnancy, lipase has little safety data — use only if your doctor advises it.

Amla should be avoided in pregnancy due to insufficient safety data. Proteases are best avoided in pregnancy unless prescribed.

For breastfeeding, safety data for all three is limited — check with your healthcare provider first.

Side effects, ingredient by ingredient Lipase Indian Gooseberry Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Indian Gooseberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before taking Lipase-HP Plus if you're on blood thinners (anticoagulants), antiplatelet drugs (including aspirin), clopidogrel (Plavix), or diabetes medications — amla can increase bleeding risk or lower blood sugar further. No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with acid reflux and cholesterol if amla's effects hold up for you, but evidence is still incomplete. If you take blood thinners, aspirin, clopidogrel, or diabetes medications, talk to your pharmacist first — amla can interact with these.

Pregnant or breastfeeding people should ask their doctor before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lipase-HP Plus, straight from the product label.

Brand AST Enzymes
Barcode (UPC) 850213002168
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 338354
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), No Allergies, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lipase-HP Plus by AST Enzymes, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
850213002168
IngredientAmount% DV
Lipase0 NP--
Amla50 mg--
Proteases0 NP--
Amylases0 NP--
Bovine Bile50 mg--

Other ingredients: Cellulose, Maltodextrin, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Lipase Plus is a powerful digestive enzyme blend that promotes proper fat, fish oil, & nutrient absorption while supporting heart and healthy gallbladder function.

Suggested/Recommended/Usage/Directions

Directions: Take 1 or more capsules at the beginning of each meal, or as directed by your healthcare professional. For heart health take 1 capsule three times daily on an empty stomach.

Precautions

Keep out of reach of children.

Caution: If any adverse conditions occur, discontinue use and seek medical help.

Consult your doctor before use if pregnant, nursing, or taking medication.

Free of: Wheat, egg, milk, soy, tree nuts, peanuts, fish, shellfish and sesame. Manufactured in cGMP facilities that also process wheat, milk, eggs, and soy.

Storage

Storage: Closed in a cool, dry place. Avoid excessive heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

For fat digestion & low-carb diets; supports gallbladder function Professional strength

Free of: Wheat, egg, milk, soy tree nuts, peanuts, fish, shellfish and sesame.

Manufactured and laboratory tested in the USA.

Seals/Symbols

BPPS Technology Laboratory Tested

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lipase-HP Plus by AST Enzymes label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lipase-HP Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lipase-HP Plus by AST Enzymes

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Amla

Interacts with
208 drugs
50 mg per serving

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...

Amla monograph & interactions

Proteases

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Proteases monograph & interactions

Amylases

0 NP per serving

Bovine Bile

50 mg per serving

Other (inactive) ingredients: Cellulose, Maltodextrin, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lipase-HP Plus by AST Enzymes Drug Interactions

Want to check YOUR meds against Lipase-HP Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Amla 208

Individual Drug Interactions

The ingredients in Lipase-HP Plus interact with 208 drugs. Click any drug to see the details.

1 of the 5 ingredients in Lipase-HP Plus interact with drugs. Each result below shows which ingredient is responsible. Amla

Each ingredient & the kinds of drugs it affects

For each ingredient in Lipase-HP Plus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Amla4 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Aspirin

Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.

Likelihood Possible Evidence B
Amla full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lipase-HP Plus, from the product label.

AST Enzymes

See all AST Enzymes products
Name
AST Enzymes
Street Address
13591 Yorba Ave.
City
Chino
State
CA
ZipCode
91710
Web Address
www.ASTenzymes.com
Pharmacist Counseling Corner

Lipase-HP Plus by AST Enzymes: Common Questions

Does Lipase-HP Plus by AST Enzymes interact with any medications?
Yes. Based on its ingredients, Lipase-HP Plus has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lipase-HP Plus contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
No. The three ingredients with safety data — lipase, amla, and proteases — all have too little pregnancy safety information. Amla should be avoided in pregnancy. Talk with your doctor before using any of these during pregnancy.
Can I take this while breastfeeding?
There isn't enough safety data to know either way for lipase, amla, or proteases during breastfeeding. Check with your healthcare provider first before starting.
What does amla do in this product?
Amla (Indian gooseberry) is included for its potentially helpful effects on acid reflux and cholesterol levels. It's rated possibly effective for both, though more research is still needed.
Does this really help with digestion?
Lipase and proteases are digestive enzymes meant to break down fats and proteins, but the evidence for their effectiveness in supplement form isn't yet established in our data. If you have specific digestive concerns, ask your pharmacist whether this product is right for you.
What side effects should I watch for?
No adverse effects have been reported with lipase in adults with normal use. Amla caused stomach discomfort in a small number of trial participants; proteases may occasionally cause digestive upset or allergic reactions. Stop and contact your doctor if you have unusual symptoms.
Will this interact with my aspirin?
Yes — amla in this product can increase your bleeding risk when taken with aspirin. Check with your pharmacist before starting, especially if you're on aspirin for heart health or stroke prevention.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lipase-HP Plus label
Go deeper

The Full Monographs Behind Lipase-HP Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Indian Gooseberry

Interacts with 208 drugs

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...

Read the full Indian Gooseberry monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Lipase-HP Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Indian Gooseberry 6 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

See these in context on the Indian Gooseberry monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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