No known drug interactions for the matched ingredients — not a guarantee none exist. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

M-S-M Sulfur 1,000 mg Ingredients & Drug Interactions

by Carlson

Capsule Category: Other Combinations
No known interaction
The interaction bottom line No known interaction

M-S-M Sulfur 1,000 mg is a dietary supplement by Carlson with 2 active ingredients. Its ingredients are commonly taken for acne and oily skin, rosacea, seborrheic dermatitis and dandruff.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of M-S-M Sulfur 1,000 mg by Carlson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This capsule contains two active ingredients: 1,000 mg of sulfur and OptiMSM (methylsulfonylmethane, a form of sulfur compound). Sulfur is a mineral that's been used topically for skin conditions like scabies and dandruff.

This product delivers it orally, which is less studied than skin applications. The capsule itself is made with hypromellose, an inactive ingredient that helps hold it together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: joint function and connective tissue support.
  • We looked for evidence on: osteoarthritis, cartilage health, joint pain.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Sulfur is possibly effective for scabies and dandruff when applied to skin. For acne, hay fever, COPD, and the common cold, the evidence isn't established in the data we hold — we can't say whether oral sulfur helps these conditions.

OptiMSM's effectiveness we cannot assess; the data isn't on file for us.

The evidence, ingredient by ingredient Sulfur

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Topical sulfur up to 10% concentration is generally well tolerated, though it can dry out skin, cause irritation, or itch. Taken by mouth, sulfur is much less studied.

Oral sulfur can cause diarrhea and, in rare cases with very high doses and certain health conditions, a serious condition called metabolic acidosis (buildup of acid in the blood). One case involved a woman who took about 250 grams over 6 days while dealing with diabetes and kidney problems.

At the 1,000 mg dose in this product, risk is lower, but talk with your doctor or pharmacist before starting, especially if you have kidney disease, diabetes, or digestive issues. For pregnancy and breastfeeding, there isn't enough data to know either way — discuss this with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Sulfur

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That said, talk with your pharmacist about your specific medications just to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

This product might be worth considering if you've been reading about sulfur for a skin condition like scabies or dandruff and want to try it orally, though the science is stronger for topical use. If you have kidney disease, diabetes, or a history of diarrhea, check with your doctor or pharmacist first.

Even though no drug interactions show up, it's still smart to run your medication list by your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about M-S-M Sulfur 1,000 mg, straight from the product label.

Brand Carlson
Barcode (UPC) 088395872303
Net contents 300 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 309939
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for M-S-M Sulfur 1,000 mg by Carlson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
300
UPC/BARCODE
088395872303
IngredientAmount% DV
Sulfur330 mg--
OptiMSM1000 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Superior bioavailability Joint function Connective tissue support Healthy skin

Gluten-free No artificial preservatives

Potency & quality guaranteed An FDA Regulated Facility

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Carlson Providing the highest quality nutritional supplements since 1965

OptiMSM OptiMSM is a registered trademark of Balchem Corporation or its subsidiaries

Suggested/Recommended/Usage/Directions

Directions: Adults: Take one capsule up to six times daily at mealtime.

Storage

Keep bottle tightly closed. Store away from heat and moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Mineral depletion in the soil and mineral loss through food preparation make it difficult for us to get an adequate amount of sulfur. Carlson MSM Sulfur from OptiMSM is a highly bioavailable form of sulfur that's found in many of our body's tissues. It supports joint health by helping to maintain healthy connective tissue and is an important component of skin, hair, and nail proteins.

General Statements

Impact Collective Reduced Plastic Impact

See for yourself

M-S-M Sulfur 1,000 mg by Carlson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in M-S-M Sulfur 1,000 mg by Carlson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container300 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sulfur

No known
interactions
330 mg per serving

Sulfur is a mineral used mainly in topical skin products for acne, rosacea, dandruff, and certain skin infections, and has a long history in dermatolo...

Sulfur monograph & interactions

OptiMSM

1000 mg per serving Form: Methylsulfonylmethane

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

M-S-M Sulfur 1,000 mg by Carlson Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in M-S-M Sulfur 1,000 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for M-S-M Sulfur 1,000 mg, from the product label.

Carlson

See all Carlson products
Name
Carlson Div. of J.R. Carlson Laboratories, Inc.
City
Arlington Heights
State
IL
ZipCode
60004
Phone Number
888-234-5656
Web Address
www.carlsonlabs.com
Pharmacist Counseling Corner

M-S-M Sulfur 1,000 mg by Carlson: Common Questions

Does M-S-M Sulfur 1,000 mg by Carlson interact with any medications?
We do not currently list a known interaction for the mapped ingredients in M-S-M Sulfur 1,000 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
M-S-M Sulfur 1,000 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this oral sulfur irritate my stomach?
Oral sulfur can cause diarrhea and intestinal irritation because it gets broken down in your gut into sulfide compounds. Very high doses (much more than this 1,000 mg capsule) have caused serious problems in rare cases, but at typical doses the main risk is loose stools. If you have a sensitive stomach or IBS, mention it to your doctor or pharmacist first.
Is this safe if I'm pregnant or breastfeeding?
There isn't enough data to know whether oral sulfur is safe during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you in these situations.
What's OptiMSM in the label?
OptiMSM is a brand name for methylsulfonylmethane, another form of sulfur compound. We don't have detailed data on file for it, so we can't assess its effectiveness or safety separately from the plain sulfur in the product.
Does this actually work for acne?
The evidence for sulfur on acne isn't established in the data we hold. There's stronger evidence for it on scabies and dandruff when applied to skin, but whether oral sulfur helps acne is unclear.
Can I take this if I have kidney problems?
You should talk with your doctor or pharmacist first. Oral sulfur is converted in your body to compounds that are processed by your kidneys, and in rare cases of very high doses, it's contributed to a serious acid buildup in the blood — especially in people with kidney disease. Your doctor can weigh the risks for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if M-S-M Sulfur 1,000 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

M-S-M Sulfur 1,000 mg label
Go deeper

The Full Monographs Behind M-S-M Sulfur 1,000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

M-S-M Sulfur 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sulfur 17 references
  1. Blum, J. E. and Coe, F. L. Metabolic acidosis after sulfur ingestion. N Engl J Med 1977;297(16):869-70. PubMed
  2. Roos, T. C., Alam, M., Roos, S., Merk, H. F., and Bickers, D. R. Pharmacotherapy of ectoparasitic infections. Drugs 2001;61(8):1067-88. PubMed
  3. Diaz, M., Cazorla, D., and Acosta, M. [Efficacy, safety and acceptability of precipitated sulphur petrolatum for topical treatment of scabies at the city of Coro, Falcon State, Venezuela]. Rev Invest Clin 2004;56(5):615-22.
  4. Schmiedel, V. and Klein, P. A complex homeopathic preparation for the symptomatic treatment of upper respiratory infections associated with the common cold: An observational study. Explore (NY) 2006;2(2):109-14. PubMed
  5. Weiser, M., Gegenheimer, L. H., and Klein, P. A randomized equivalence trial comparing the efficacy and safety of Luffa comp.-Heel nasal spray with cromolyn sodium spray in the treatment of seasonal allergic rhinitis. Forsch Komplementarmed 1999;6(3):142- PubMed
  6. FDA OTC ingredients list, April 2010. Available at: www.fda.gov/downloads/AboutFDA/CentersOffices/CDER/UCM135691.pdf (accessed 2/7/15).
  7. Leyden, J. J., McGinley, K. J., Mills, O. H., Kyriakopoulos, A. A., and Kligman, A. M. Effects of sulfur and salicylic acid in a shampoo base in the treatment of dandruff: a double-blind study using corneocyte counts and clinical grading. Cutis 1987;39(6)
  8. Trumbore, M. W., Goldstein, J. A., and Gurge, R. M. Treatment of papulopustular rosacea with sodium sulfacetamide 10%/sulfur 5% emollient foam. J Drugs Dermatol 2009;8(3):299-304.
  9. Pelle, M. T., Crawford, G. H., and James, W. D. Rosacea: II. Therapy. J Am Acad Dermatol 2004;51:499-512.
  10. Blom I, Hornmark AM. Topical treatment with sulfur 10 per cent for rosacea. Acta Derm Venereol 1984;64:358-9. DOI
  11. Gupta, A. K. and Nicol, K. The use of sulfur in dermatology. J Drugs Dermatol 2004;3(4):427-31.
  12. Akhavan, A. and Bershad, S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol 2003;4(7):473-92.
  13. Wilkinson RD, Adam JE, Murray JJ, Craig GE. Benzoyl peroxide and sulfur: foundation for acne management. Can Med Assoc J 1966;95(1):28-9.
  14. Food and Drug Administration. Classification of benzoyl peroxide as safe and effective and revision of labeling to drug facts format; topical acne drug products for over-the-counter human use; final rule. Federal Register 2010;75(42):9767-77.
  15. Lin, A. N., Reimer, R. J., and Carter, D. M. Sulfur revisited. J Am Acad Dermatol 1988;18(3):553-8.
  16. Goszcz, A., Kostka-Trabka, E., Grodzinska, L., et al. [The effect of treatment with sulphur water from the spring in Wieslaw in Busko-Solec on levels of lipids, the fibrinolytic system and thrombogenic platelet function in patients with arteriosclerosis].
  17. Contoli M, Gnesini G, Forini G, et al. Reducing agents decrease the oxidative burst and improve clinical outcomes in COPD patients: a randomised controlled trial on the effects of sulphurous thermal water inhalation. ScientificWorldJournal. 2013 Dec 23;20 PubMed

See these in context on the Sulfur monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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