No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Male Fern Ingredients & Drug Interactions

by Pure Herbs

Male Fern label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Male Fern against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Male Fern is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for intestinal worms (especially tapeworm), traditional deworming remedy, folk wound care.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

Jump to a section

HelloPharmacist Scorecard of Male Fern by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Herbs Male Fern contains one active ingredient: Male Fern Root Extract. The product is a liquid formulation with no inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Male Fern product and its label doesn't state a use — see Male Fern's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Male Fern is insufficient to rate it reliably for any of its claimed uses — hemorrhoids, intestinal parasite infection, rheumatoid arthritis, and wound healing all fall into that category. That means we don't have solid trial data showing whether it actually works for these purposes.

The evidence, ingredient by ingredient Male Fern

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Male Fern carries serious safety concerns. When taken by mouth, it may cause nausea, diarrhea, headaches, tremors, vertigo, and breathing problems.

In rare cases of severe poisoning, it can trigger seizures, muscle weakness, temporary or permanent blindness, heart and breathing failure, coma, and death. The margin between a dose intended to work and one that poisons you is very narrow — a small error in amount could be dangerous.

The safety data advises against use in pregnancy due to toxicity and risk of harm to the pregnancy. Safety is unknown during breastfeeding, so it should be avoided.

Side effects, ingredient by ingredient Male Fern

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we checked. However, because Male Fern itself carries a narrow safety margin and serious toxicity risk, you should still discuss it with your doctor or pharmacist before starting it, especially if you take any medications.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Male Fern's toxic potential and the lack of reliable evidence for what it's meant to treat make this a supplement to approach with real caution. If you're considering it, talk it over with your doctor or pharmacist first — they can weigh whether the possible benefits outweigh the real safety risks for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Male Fern, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279825
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Male Fern by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Male Fern Root Extract1887 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial as a tonic for overall health. Helps to support the body's natural ability to remove toxins.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Male Fern by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Male Fern label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Male Fern by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Male Fern Root Extract

No known
interactions
1887 mg per serving

Male fern is an old herbal remedy that was once used as a powerful treatment to expel tapeworms. It is now considered outdated and potentially dangero...

Male Fern Root Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Male Fern by Pure Herbs Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Male Fern. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Male Fern, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Male Fern by Pure Herbs: Common Questions

Does Male Fern by Pure Herbs interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Male Fern. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Male Fern contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Male Fern used for?
Male Fern Root Extract has been traditionally used for hemorrhoids, intestinal parasite infection, rheumatoid arthritis, and wound healing. However, we don't have strong evidence that it actually works for any of these uses.
What are the side effects?
Common side effects when taken by mouth include nausea, diarrhea, headaches, tremors, vertigo, and difficulty breathing. Serious but rare effects of poisoning include seizures, muscle weakness, blindness, heart and breathing failure, coma, and death. The toxic dose is dangerously close to the dose meant to be effective.
Is it safe to take during pregnancy?
No. Male Fern is considered likely unsafe in pregnancy due to its toxicity and potential to harm the pregnancy.
Is it safe while breastfeeding?
Safety during breastfeeding is unknown, and because of the toxicity risk, it should be avoided.
Does Male Fern interact with medications?
No interactions are documented in our data for the ingredient we checked. However, absence of documented interactions doesn't mean none exist, and the product's own toxicity concerns are significant enough that you should clear it with your doctor or pharmacist before taking it alongside any medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Male Fern is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Male Fern label
Go deeper

The Full Monographs Behind Male Fern’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Male Fern

Male fern is an old herbal remedy that was once used as a powerful treatment to expel tapeworms. It is now considered outdated and potentially dangerous because of its narrow safety margin a...

Read the full Male Fern monograph →
Sources

Sources & How We Checked

Male Fern's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Male Fern 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

See these in context on the Male Fern monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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