Methionine 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Methionine 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Methionine 500 mg is a dietary supplement by Seeking Health with 1 active ingredient. Its ingredients are commonly taken for acetaminophen (tylenol) overdose support, liver health, urinary tract acidification.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Methionine 500 mg by Seeking Health
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: L-methionine, an amino acid your body uses to build proteins and support various metabolic processes. The capsule itself is vegetarian, and it includes inactive ingredients like L-leucine, silicon dioxide, and cellulose — standard binders and flow agents.
Does it work?
Moderate evidence
The evidence we hold shows methionine is possibly effective for reducing the risk of neural tube birth defects. For acetaminophen poisoning, hay fever, asthma, colorectal cancer, the evidence isn't established in our data.
That doesn't mean it won't help — it means the studies we have are too limited or mixed to say either way. Talk with your doctor about whether this supplement fits your particular situation.
How safe is it?
Well-documented data
Methionine from food is safe; the supplement form at high doses is a different story and needs medical guidance. When taken by mouth, it's generally well tolerated in everyday use, though dizziness, drowsiness, headache, irritability, and vomiting can occur.
High-dose methionine (in the range of 75–100 mg per kilogram of body weight daily) may raise homocysteine levels, a risk factor for vascular disease, though that risk hasn't been clearly proven. Rare serious effects like brain swelling (cerebral edema) have been reported.
For pregnancy, the data shows it's likely safe, but high-dose supplement use during pregnancy hasn't been formally proven safe — stick with food amounts or talk with your doctor. For breastfeeding, safety isn't well studied at supplement doses, so again, check with your pharmacist or doctor.
Meds to double-check
No known interactions
No interactions are documented in our data for methionine. Still, run your exact medications through the search tool on this page before starting.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
Methionine is an amino acid naturally in food that may help with neural tube defect risk in pregnancy. If you're considering high-dose supplements, especially with a history of heart disease or blood vessel problems, talk with your doctor first — they'll know your full picture.
Check with your pharmacist about your specific medications, though no documented interactions are on file for this ingredient.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Methionine 500 mg, straight from the product label.
| Brand | Seeking Health |
|---|---|
| Barcode (UPC) | 828054147249 |
| Net contents | 100 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 23, 2018 |
| DSLD ID | 174533 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Methionine 500 mg by Seeking Health, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Methionine | 500 mg | -- |
Other ingredients: Vegetarian Capsule, L-Leucine, Silicon Dioxide, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 capsule daily with food or as directed by your health care professional.
Formula
This product contains L-Methionine, an essential sulfur-containing amino acid that is used to form other amino acids such as cysteine and taurine as well as other important compounds such as S-adenosylmethionine, an important methyl donor.
General Statements
A natural sulfur odor is characteristic of this product.
This product was made in a GMP and ISO 9001:2008 registered facility.
Physician formulated
Precautions
Do not use if full-bottle shrinkwrap is broken or missing.
Storage
Store in a cool, dry place (59(0)F-85(0)F) away from direct light.
Keep out of reach of children.
FDA Statement of Identity
Amino Acid Supplement
Formulation
Does Not Contain: Milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, corn, yeast, and soybeans. Contains no artificial colors, flavors, or preservatives.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Methionine 500 mg by Seeking Health label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Methionine 500 mg by Seeking Health
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
L-Methionine
No knowninteractions
Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a norma...
L-Methionine monograph & interactionsOther (inactive) ingredients: Vegetarian Capsule, L-Leucine, Silicon Dioxide, Cellulose. These complete the product’s ingredient list but are not active constituents.
Methionine 500 mg by Seeking Health Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Methionine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Methionine 500 mg, from the product label.
Seeking Health
See all Seeking Health products- Name
- Seeking Health
- Street Address
- 3140 Mercer Ave
- City
- Bellingham
- State
- WA
- ZipCode
- 98225
- Phone Number
- (800) 547-9812
- Web Address
- www.seekinghealth.com
Methionine 500 mg by Seeking Health: Common Questions
Does Methionine 500 mg by Seeking Health interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is methionine safe to take while pregnant?
Is methionine safe while breastfeeding?
What side effects can methionine cause?
Does methionine actually work for hay fever or asthma?
What is methionine used for in the body?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Methionine 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Methionine 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Methionine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Methionine 12 references
- La Vecchia C, Negri E, Franceschi S, Decarli A. Case-control study on influence of methionine, nitrite, and salt on gastric carcinogenesis in northern Italy. Nutr Cancer 1997;27:65-8. PubMed
- Btaiche IF, Khalidi N. Parenteral nutrition-associated liver complications in children. Pharmacotherapy 2002;22:188-211.. PubMed
- Cottington EM, LaMantia C, Stabler SP, et al. Adverse event associated with methionine loading test: a case report. Arterioscler Thromb Vasc Biol 2002;22:1046-50.. PubMed
- Anon. Should methionine be added to paracetamol formulations? Drug Ther Perspect 1997;10:11-3. DOI
- Smulders, Y. M., Rakic, M., Slaats, E. H., Treskes, M., Sijbrands, E. J., Odekerken, D. A., Stehouwer, C. D., and Silberbusch, J. Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and c
- McAuley, D. F., Hanratty, C. G., McGurk, C., Nugent, A. G., and Johnston, G. D. Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation. J.Toxicol.Clin.Toxicol. 1999;37(4):435-440. PubMed
- Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
- Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
- Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
- Talukdar R, Murthy HV, Reddy DN. Role of methionine containing antioxidant combination in the management of pain in chronic pancreatitis: a systematic review and meta-analysis. Pancreatology 2015;15(2):136-44. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226 DOI
- Khairan P, Sobue T, Eshak ES, et al. Association of B Vitamins and Methionine Intake with the Risk of Gastric Cancer: The Japan Public Health Center-based Prospective Study. Cancer Prev Res (Phila) 2022;15(2):101-110. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC