Major interaction on record — check this product against your medications before combining. Based on 7 of 10 ingredients. Check your meds →
Dietary supplement

Morphoburn Ingredients & Drug Interactions

by Morphogen Nutrition

Morphoburn label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Morphoburn against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Morphoburn is a dietary supplement by Morphogen Nutrition with 10 active ingredients. Its ingredients are commonly taken for water retention (diuretic), digestive upset, liver and gallbladder support.Based on those ingredients, 1,247 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ForsLean, Green Coffee extract, Dandelion. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Morphoburn by Morphogen Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Morphoburn by Morphogen Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Morphoburn by Morphogen Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Morphoburn contains 10 active ingredients. The main ones include dandelion root (a plant often used as a diuretic), green coffee extract (which supplies caffeine and chlorogenic acid), 3,3-diiodothyronine (a thyroid-related compound), elevATP (a patented form of ATP), Paradoxine grains of paradise extract (a spice), ForsLean (a standardized extract of coleus), InnoSlim (a proprietary ingredient we have no data for), Capsimax (capsicum pepper extract), Laminaria japonica algae powder (a seaweed rich in iodine and potassium), and Lean GBB (another proprietary ingredient we have no data for).

The capsules also contain inactive ingredients: FD&C Blue #1, Red #3, Yellow #6, and the capsule shell itself.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight loss and metabolism support.
  • We looked for evidence on: Obesity, Athletic performance, Metabolic syndrome, fat loss, thermogenesis, energy expenditure.
  • The closest evidence on file: Laminaria is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Capsicum is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Obesity.
  • Also on file: Coffee is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

The evidence for most of Morphoburn's ingredients is weak or not yet established. Dandelion's use for joint pain, swelling, and postoperative pain all have insufficient evidence to rate.

Green coffee shows better data — it's likely effective for mental alertness and possibly effective for Parkinson's disease, heart failure, and diabetes. However, 3,3-diiodothyronine, grains of paradise, coleus, capsicum, and laminaria all lack established effectiveness ratings or have insufficient evidence for their intended uses in this product.

Capsicum does have evidence for postherpetic neuralgia (nerve pain after shingles) and diabetic neuropathy when used topically, though that's not this product's form or claim.

The evidence, ingredient by ingredient Dandelion Coffee Diiodothyronine Grains Of Paradise Coleus Capsicum Laminaria

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Green coffee extract is generally well tolerated in moderate amounts, though high doses can cause jitteriness, anxiety, insomnia, and stomach upset — effects that increase with caffeine intake. Dandelion is generally well tolerated as food but may cause diarrhea, heartburn, or stomach discomfort at supplement doses; it can also trigger allergic reactions, including anaphylaxis, in people sensitive to ragweed and related plants.

Coleus seems well tolerated orally but can cause diarrhea and nausea; long-term safety is not well studied. Capsicum is generally safe as food but causes burning and irritation; concentrated supplements are less studied.

Laminaria is safe as food but supplements deliver high and variable amounts of iodine that can affect thyroid function, and some batches contain arsenic. 3,3-diiodothyronine is a thyroid-active compound with limited human safety data and possible effects on heart and thyroid function.

Side effects, ingredient by ingredient Dandelion Coffee Diiodothyronine Grains Of Paradise Coleus Capsicum Laminaria

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Laminaria, Dandelion, Capsicum, Coffee, Coleus.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Major interactions exist with nitrates and calcium channel blockers (coleus); check these first if you take either. Moderate interactions span blood thinners and anticoagulants, diabetes drugs, potassium-sparing diuretics and ACE inhibitors, lithium, thyroid drugs (antithyroid or replacement), clozapine, fluvoxamine, and amiodarone.

If you take any of these, confirm with your doctor or pharmacist that it's safe to add this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product contains multiple ingredients with serious medication interactions — especially if you take blood pressure drugs, blood thinners, diabetes drugs, or thyroid medications. Even if you don't take prescription drugs, the thyroid-active compound, high iodine content, and caffeine load mean you should talk with your doctor or pharmacist before starting.

Green coffee extract does have some solid evidence for mental alertness, but most other ingredients lack strong proof of benefit for weight or body composition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Morphoburn, straight from the product label.

Brand Morphogen Nutrition
Barcode (UPC) 653341224941
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 212754
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Morphoburn by Morphogen Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
653341224941
IngredientAmount% DV
Dandelion300 mg--
Green Coffee extract500 mg--
3,3-Diiodothyronine150 mcg--
elevATP75 mg--
Paradoxine Grains of Paradise extract225 mg--
ForsLean125 mg--
InnoSlim125 mg--
Capsimax50 mg--
Laminaria japonica (Algae Kombu) powder25 mg--
Lean GBB12.5 mg--

Other ingredients: Capsule, FD&C Blue #1, Red #3, Yellow #6

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take 2 capsules twice daily. Do not use more than 2 capsules at once. Do not use more than 3 servings (6 capsules) in a 24 hour period. Can be stacked with other supplements including Morpholean and Alphagen.

Precautions

Warnings: Not intended for use by persons under the age of 18.

If you are pregnant or nursing or are taking any prescription medications, consult your health care professional before using this or any other dietary supplement product.

Immediately discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Storage

Store in a cool, dry place and avoid excessive heat.

Brand IP Statement(s)

Paradoxine is a registered trademark of Suzhou Win Health International Co., Ltd. ForsLean is a registered trademark of Sabinsa Corporation. InnoSlim is a registered trademark of NuLiv Science. elevATP is a registered trademark of FutureCeuticals. Capsimax is a registered trademark of OmniActive Health Technologies. Lean GBB is a registered trademark and patented by Genabolix.

Formulation

All day all year non stim fat loss Calorie wasting Dry Metabolism

High potency formula

Pure ingredients

Maximum performance

May assist with: Fat oxidation Thermogenesis Metabolism ATP production Water retention & bloating Dry, hard physique Calorie wasting Safe for men and women Year round fat loss support; doesn't need cycled

Formula

with: Paradoxine elevATP Strength Power Performance ForsLean Capsimax InnoSlim Lean GBB

FDA Statement of Identity

Dietary Supplement

General Statements

Specializes in developing no BS, scientifically validated, effectively dosed and affordable sports nutrition supplements Knowledge Honestly Integrity No BS

Join the takeover

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Manufactured in THE USA for Morphogen Nutrition GMP Good Manufacturing Practice Quality Product FDA registered Lab Tested 3rd party certified for purity & potency

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Morphoburn by Morphogen Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Morphoburn label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Morphoburn by Morphogen Nutrition

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dandelion

Interacts with
457 drugs
300 mg per serving

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for thes...

Dandelion monograph & interactions

Green Coffee extract

Interacts with
591 drugs
500 mg per serving Form: Chlorogenic Acid

Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy. For most healt...

Green Coffee extract monograph & interactions

3,3-Diiodothyronine

No known
interactions
150 mcg per serving

Diiodothyronine (T2) is a thyroid hormone metabolite sold as a fat-loss and metabolism supplement, mostly in the bodybuilding world. Human evidence fo...

3,3-Diiodothyronine monograph & interactions

ElevATP

75 mg per serving Form: Ancient Peat, Apple Extract

Paradoxine Grains of Paradise extract

No known
interactions
225 mg per serving Form: 6-Paradol

Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at m...

Paradoxine Grains of Paradise extract monograph & interactions

ForsLean

Interacts with
915 drugs
125 mg per serving Form: Coleus forskohlii extract

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

ForsLean monograph & interactions

InnoSlim

125 mg per serving Form: Astragalus membranaceous, Panax notoginseng

Capsimax

Interacts with
239 drugs
50 mg per serving

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin p...

Capsimax monograph & interactions

Laminaria japonica (Algae Kombu) powder

Interacts with
69 drugs
25 mg per serving Form: Fucoxanthin

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because it...

Laminaria japonica (Algae Kombu) powder monograph & interactions

Lean GBB

12.5 mg per serving Form: Gamma-Butyrobetaine Ethyl Ester

Other (inactive) ingredients: Capsule, FD&C Blue #1, Red #3, Yellow #6. These complete the product’s ingredient list but are not active constituents.

Interaction report

Morphoburn by Morphogen Nutrition Drug Interactions

Want to check YOUR meds against Morphoburn?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,247Drugs
37 Major 1,187 Moderate 23 Minor

Ingredients driving the most interactions

ForsLean 915
Green Coffee extract 591
Dandelion 457
Capsimax 239
Laminaria japonica (Algae Kombu) powder 69

Individual Drug Interactions

The ingredients in Morphoburn interact with 1,247 drugs. Click any drug to see the details.

5 of the 10 ingredients in Morphoburn interact with drugs. Each result below shows which ingredient is responsible. ForsLean Green Coffee extract Dandelion Capsimax Laminaria japonica (Algae Kombu) powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Morphoburn with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

ForsLean7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
ForsLean full monograph & interactions

Green Coffee extract33 drug types · 591 drugs

Ephedrine

Theoretically, concomitant use might increase the risk of stimulant adverse effects.
Coffee contains caffeine. There is evidence that using ephedrine with caffeine might increase the risk of serious life-threatening or debilitating adverse effects such as hypertension, myocardial infarction, stroke, seizures, and death. Tell patients to avoid taking caffeine with ephedrine and other stimulants.

Likelihood Probable Evidence D
Adenosine (Adenocard)

Theoretically, coffee might decrease the vasodilatory effects of adenosine and interfere with its use prior to stress testing.
Coffee contains caffeine. Caffeine is a competitive inhibitor of adenosine at the cellular level. However, caffeine does not seem to affect supplemental adenosine because high interstitial levels of adenosine overcome the antagonistic effects of caffeine. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products, be stopped 24 hours prior to pharmacological stress tests. However, methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Possible Evidence B
Alendronate (Fosamax)

Coffee reduces alendronate bioavailability.
Separate coffee ingestion and alendronate administration by two hours. Coffee reduces alendronate bioavailability by 60%.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, coffee may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Coffee contains caffeine. Caffeine is reported to have antiplatelet activity. Theoretically, the caffeine in coffee might increase the risk of bleeding when used concomitantly with these agents. However, this interaction has not been reported in humans. There is some evidence that caffeinated coffee might increase the fibrinolytic activity in blood.

Likelihood Unlikely Evidence D
Beta-Adrenergic Agonists

Theoretically, concomitant use of large amounts of coffee might increase cardiac inotropic effects of beta-agonists.
Coffee contains caffeine. Caffeine can increase cardiac inotropic effects of beta-agonists.

Likelihood Probable Evidence D
Cimetidine (Tagamet)

Theoretically, cimetidine might increase the effects and adverse effects of caffeine in coffee.
Coffee contains caffeine. Cimetidine can reduce caffeine clearance by 31% to 42%.

Likelihood Likely Evidence B
Clozapine (Clozaril)

Theoretically, coffee might increase the levels and adverse effects of clozapine and acutely exacerbate psychotic symptoms.
Coffee contains caffeine. Caffeine can increase the effects and toxicity of clozapine. Caffeine doses of 400-1000 mg daily inhibit clozapine metabolism. Clozapine is metabolized by cytochrome P450 1A2 (CYP1A2). Researchers speculate that caffeine might inhibit CYP1A2. However, there is no reliable evidence that caffeine affects CYP1A2. There is also speculation that genetic factors might make some patients be more sensitive to the interaction between clozapine and caffeine.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, concomitant use might increase the effects and adverse effects of caffeine found in coffee.
Coffee contains caffeine. Oral contraceptive drugs can decrease caffeine clearance by 40% to 65%.

Likelihood Probable Evidence B
Dipyridamole (Persantine)

Theoretically, coffee might decrease the vasodilatory effects of dipyridamole and interfere with its use prior to stress testing.
Coffee contains caffeine. Caffeine is a methylxyanthine that may inhibit dipyridamole-induced vasodilation. It is recommended that methylxanthines such as caffeine, as well as methylxanthine-containing products such as coffee, be stopped 24 hours prior to pharmacological stress tests. Methylxanthines appear more likely to interfere with dipyridamole (Persantine) than adenosine-induced stress testing.

Likelihood Probable Evidence B
Disulfiram (Antabuse)

Theoretically, disulfiram might increase the risk of adverse effects from caffeine.
Coffee contains caffeine. In human research, disulfiram decreases the clearance and increases the half-life of caffeine.

Likelihood Probable Evidence B
Diuretic Drugs

Theoretically, concomitant use might increase the risk of hypokalemia.
Coffee contains caffeine. Caffeine, especially in excessive amounts, can reduce potassium levels due to stimulation of the sodium-potassium pump. Diuretics can also cause lower potassium levels.

Likelihood Possible Evidence D
Estrogens

Theoretically, estrogens might increase the levels and adverse effects of caffeine.
Coffee contains caffeine. Estrogen inhibits caffeine metabolism.

Likelihood Probable Evidence B
Fluvoxamine (Luvox)

Theoretically, fluvoxamine might increase the levels and adverse effects of caffeine.
Coffee contains caffeine. Fluvoxamine reduces caffeine metabolism.

Likelihood Probable Evidence B
Lamotrigine (Lamictal)

Coffee consumption can decrease the levels and clinical effects of lamotrigine.
A pharmacokinetic study in patients taking lamotrigine shows that consumption of coffee, both caffeinated and decaffeinated, can decrease the area under the concentration-time curve (AUC) and the peak plasma level (Cmax) of lamotrigine. Each additional cup of coffee reduced the AUC and Cmax by 4% and 3%, respectively. It is unclear whether this interaction is due to induction of lamotrigine metabolism or inhibition of lamotrigine absorption.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Coffee can reduce the absorption of levothyroxine.
In some patients, coffee can reduce levothyroxine absorption, possibly through the formation of non-absorbable complexes. A pharmacokinetic study in these patients found that 25-30 mL of espresso coffee consumed with levothyroxine tablets delayed the time to peak plasma levels by 38-43 minutes, reduced the peak plasma level (Cmax) by 19% to 36%, and reduced the area under the curve (AUC) by 27% to 36%. Coffee consumed one hour after levothyroxine did not affect absorption. It is not known whether this interaction occurs with other types of coffee. Tell patients to avoid drinking coffee at the same time that they take their levothyroxine, and for up to an hour afterwards.

Likelihood Possible Evidence B
Lithium

Theoretically, abrupt coffee withdrawal might increase the levels and adverse effects of lithium.
Coffee contains caffeine. Abrupt caffeine withdrawal can increase serum lithium levels. Two cases of lithium tremor that worsened with abrupt coffee withdrawal have been reported. There is also one case of a 2.8-fold increase in blood lithium levels after a patient taking lithium reduced his coffee consumption from 13-20 cups daily to 10 cups daily.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use might increase the risk of a hypertensive crisis.
Coffee contains caffeine. Caffeine has been shown to inhibit monoamine oxidase (MAO) A and B in laboratory studies. Concomitant intake of large amounts of caffeine with MAOIs might precipitate a hypertensive crisis. In a case report, a patient that consumed 10-12 cups of caffeinated coffee and took the MAOI tranylcypromine presented with severe hypertension. Hypertension was resolved after the patient switched to drinking decaffeinated coffee.

Likelihood Possible Evidence D
Nicotine

Theoretically, concomitant use might increase the risk of hypertension.
Coffee contains caffeine. Concomitant use of caffeine and nicotine has been shown to have additive cardiovascular effects, including increased heart rate and blood pressure. Blood pressure was increased by 10.8/12.4 mmHg when the agents were used concomitantly.

Likelihood Probable Evidence B
Pentobarbital (Nembutal)

Theoretically, coffee might reduce the effects of pentobarbital.
Coffee contains caffeine. Theoretically, caffeine might negate the hypnotic effects of pentobarbital.

Likelihood Possible Evidence B
Phenylpropanolamine

Theoretically, phenylpropanolamine might increase the risk of hypertension, as well as the levels and adverse effects of caffeine.
Coffee contains caffeine. Concomitant use of phenylpropanolamine and caffeine might cause an additive increase in blood pressure. Phenylpropanolamine also seems to increase caffeine serum levels.

Likelihood Probable Evidence B
Pioglitazone (Actos)

Theoretically, coffee might increase the levels and clinical effects of pioglitazone.
Coffee contains caffeine. Animal research suggests that caffeine can modestly increase the maximum concentration, area under the curve, and half-life of pioglitazone, and also reduce its clearance. This increased the antidiabetic effects of pioglitazone. However, the exact mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, quinolone antibiotics might increase the levels and adverse effects of caffeine.
Coffee contains caffeine. Concomitant use of caffeine and quinolones can decrease caffeine clearance and increase effects and risk of adverse effects.

Likelihood Probable Evidence B
Riluzole (Rilutek)

Theoretically, concomitant use might increase the levels and adverse effects of both caffeine and riluzole.
Coffee contains caffeine. Caffeine and riluzole are both metabolized by cytochrome P450 1A2 (CYP1A2), and concomitant use might reduce metabolism of one or both agents.

Likelihood Possible Evidence D
Stimulant Drugs

Theoretically, concomitant use might increase stimulant adverse effects.
Coffee contains caffeine. Due to the central nervous system (CNS) stimulant effects of caffeine, concomitant use with stimulant drugs can increase the risk of adverse effects.

Likelihood Probable Evidence C
Theophylline

Theoretically, coffee might increase the levels and adverse effects of theophylline.
Coffee contains caffeine, which can increase theophylline levels.

Likelihood Probable Evidence B
Green Coffee extract full monograph & all 33 interactions

Dandelion7 drug types · 457 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking dandelion root along with anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro research suggests that dandelion root inhibits platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, dandelion might increase the risk for hypoglycemia when used with antidiabetes drugs.
Laboratory research suggests that dandelion extract may have moderate alpha-glucosidase inhibitor activity and might also increase insulin secretion. Also, in a case report, a 58-year-old woman with type 2 diabetes who was being treated with insulin developed hypoglycemia 2 weeks after beginning to eat salads containing dandelion.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, dandelion might increase levels of drugs metabolized by CYP1A2.
Laboratory research suggests that dandelion might inhibit CYP1A2. So far, this interaction has not been reported in humans. However, until more is known, watch for an increase in the levels of drugs metabolized by CYP1A2 in patients taking dandelion.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, dandelion might increase the clearance of drugs that are UDP-glucuronosyltransferase substrates.
There is some preliminary evidence that dandelion might induce UDP-glucuronosyltransferase, a phase II enzyme.

Likelihood Possible Evidence D
Lithium

Theoretically, through diuretic effects, dandelion might reduce excretion and increase levels of lithium.
Animal research suggests that dandelion has diuretic properties. As diuretics can increase serum lithium levels, the dose of lithium might need to be decreased when taken with dandelion.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically, dandelion might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dandelion contains significant amounts of potassium.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, dandelion might lower fluoroquinolone levels.
Animal research shows that dandelion reduces absorption of ciprofloxacin and can lower levels by 73%. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Dandelion full monograph & interactions

Capsimax6 drug types · 239 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.

Likelihood Possible Evidence B
Aspirin

Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.

Likelihood Unlikely Evidence D
Ciprofloxacin (Cipro)

Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.

Likelihood Possible Evidence D
Capsimax full monograph & interactions

Laminaria japonica (Algae Kombu) powder6 drug types · 69 drugs

Ace Inhibitors (Aceis)

Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.
Laminaria contains potassium.

Likelihood Possible Evidence D
Amiodarone (Cordarone)

Theoretically, combining laminaria with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with laminaria supplements, some of which may contain as much as 1000 mcg iodine, might increase the risk of adverse effects from iodine, including altered thyroid function.

Likelihood Possible Evidence D
Antithyroid Drugs

Due to its iodine content, laminaria might alter the effects of antithyroid drugs.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of antithyroid drugs.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, laminaria might increase the risk of hyperkalemia, which could increase the effects and adverse effects of digoxin.
Laminaria contains potassium.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, laminaria might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Laminaria contains potassium.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, laminaria might alter the effects of thyroid hormone.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Laminaria japonica (Algae Kombu) powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Morphoburn, from the product label.

Morphogen Nutrition

See all Morphogen Nutrition products
Name
Morphogen Nutrition
Web Address
www.mntakeover.com
Pharmacist Counseling Corner

Morphoburn by Morphogen Nutrition: Common Questions

Does Morphoburn by Morphogen Nutrition interact with any medications?
Yes. Based on its ingredients, Morphoburn has a known interaction with 1,247 medications, including 37 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Morphoburn contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have caffeine?
Yes — it contains green coffee extract, which supplies caffeine. Caffeine can cause jitteriness, anxiety, insomnia, and stomach upset, especially in sensitive people or at higher doses. If you're caffeine-sensitive, pregnant, or breastfeeding, discuss this with your doctor before taking it.
Is it safe during pregnancy?
No. The facts advise against 3,3-diiodothyronine (a thyroid-active compound), coleus, grains of paradise, and laminaria during pregnancy. Green coffee (caffeine) and capsicum are possibly safe in food amounts, but concentrated supplements are less studied. Talk with your doctor about safe amounts if you're pregnant.
Is it safe while breastfeeding?
Probably not ideal. Caffeine from green coffee passes into breast milk and can make babies fussy or sleepy. Laminaria delivers high iodine that may affect the infant's thyroid. Coleus, grains of paradise, and dandelion also lack enough breastfeeding safety data. Keep intake low and watch your baby, or check with your pharmacist first.
What's the green coffee extract for?
Green coffee is likely effective for mental alertness and possibly effective for Parkinson's disease, heart failure, and diabetes. It's mainly known for its caffeine and chlorogenic acid content, which may support alertness and blood sugar control.
Does dandelion interact with blood thinners?
Yes — the facts show a Moderate interaction. Dandelion may increase bleeding risk when used with blood thinners like warfarin. If you take a blood thinner, check with your doctor or pharmacist before starting this product.
Does this product contain iodine?
Yes — through laminaria (kelp), which can contain up to 1,000 mcg of iodine. High iodine can affect thyroid function and may interfere with thyroid drugs. If you take thyroid medication or have a thyroid condition, discuss this with your doctor first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Morphoburn label
Go deeper

The Full Monographs Behind Morphoburn’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dandelion

Interacts with 457 drugs

Dandelion is a common plant used in food and traditional medicine, often promoted as a natural 'water pill' and digestive aid. Human evidence for these uses is very limited, so its benefits...

Read the full Dandelion monograph → Herb & supplement monograph

Coffee

Interacts with 591 drugs

Coffee is a widely consumed beverage made from roasted coffee beans, valued mainly for its caffeine, which boosts alertness and energy. For most healthy adults, moderate coffee intake is gen...

Read the full Coffee monograph → Herb & supplement monograph

Diiodothyronine

Diiodothyronine (T2) is a thyroid hormone metabolite sold as a fat-loss and metabolism supplement, mostly in the bodybuilding world. Human evidence for its safety and effectiveness is very l...

Read the full Diiodothyronine monograph → Herb & supplement monograph

Grains Of Paradise

Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at metabolism. Early human research suggests...

Read the full Grains Of Paradise monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph → Herb & supplement monograph

Capsicum

Interacts with 239 drugs

Capsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...

Read the full Capsicum monograph → Herb & supplement monograph

Laminaria

Interacts with 69 drugs

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because its iodine content can be high and variabl...

Read the full Laminaria monograph →
Sources

Sources & How We Checked

Morphoburn's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 321 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dandelion 27 references
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  3. Hussain Z, Waheed A, Qureshi RA, et al. The effect of medicinal plants of Islamabad and Murree region of Pakistan on insulin secretion from INS-1 cells. Phytother Res 2004;18:73-7. PubMed
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  5. Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci 1999;88:632-4. PubMed
  6. Jovanovic M, Mimica-Dukic N, Poljacki M, Boza P. Erythema multiforme due to contact with weeds: a recurrence after patch testing. Contact Dermatitis 2003;48:17-25. PubMed
  7. Chivato T, Juan F, Montoro A, Laguna R. Anaphylaxis induced by ingestion of a pollen compound. J Investig Allergol Clin Immunol 1996;6:208-9.
  8. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol 1979;64:270-4. PubMed
  9. Lovell CR, Rowan M. Dandelion dermatitis. Contact Dermatitis 1991;25:185-8. PubMed
  10. Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
  11. Martín-Muñoz MF, Bartolome B, Caminoa M, et al. Bee pollen: a dangerous food for allergic children. Identification of responsible allergens. Allergol Immunopathol (Madr) 2010;38:263-5. PubMed
  12. Neef H, Cilli F, Declerck PJ, et al. Platelet anti-aggregating activity of Taraxacum officinale Weber. Phytotherapy Research 1996;10:s138-s140.
  13. Cuzzolin L, Zaffani S, and Benoni G. Safety implications regarding use of phytomedicines. Eur.J Clin Pharmacol. 2006;62:37-42. PubMed
  14. Posadzki, P., Watson, L. K., and Ernst, E. Adverse effects of herbal medicines: an overview of systematic reviews. Clin Med 2013;13(1):7-12. PubMed
  15. Wakelin, S. H., Marren, P., Young, E., and Shaw, S. Compositae sensitivity and chronic hand dermatitis in a seven-year-old boy. Br J Dermatol 1997;137(2):289-291. PubMed
  16. Ingber, A. Seasonal allergic contact dermatitis from Taraxacum officinale (dandelion) in an Israeli florist. Contact Dermatitis 2000;43(1):49.
  17. Rodriguez, B., Rodriguez, A., de Barrio, M., Tornero, P., and Baeza, M. L. Asthma induced by canary food mix. Allergy Asthma Proc. 2003;24(4):265-268.
  18. Syhaieva, I. A. [Efficiency of specific immunotherapy in treatment of patients with seasonal allergic rhinitis]. Lik.Sprava. 2006;(1-2):51-53.
  19. Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
  20. Goksu, E., Eken, C., Karadeniz, O., and Kucukyilmaz, O. First report of hypoglycemia secondary to dandelion (Taraxacum officinale) ingestion. Am J Emerg.Med 2010;28(1):111-112. PubMed
  21. Fernandez-Gonzalez, D., Gonzalez-Parrado, Z., Vega-Maray, A. M., Valencia-Barrera, R. M., Camazon-Izquierdo, B., De, Nuntiis P., and Mandrioli, P. Platanus pollen allergen, Pla a 1: quantification in the atmosphere and influence on a sensitizing populati
  22. Liang, K. L., Su, M. C., Shiao, J. Y., Wu, S. H., Li, Y. H., and Jiang, R. S. Role of pollen allergy in Taiwanese patients with allergic rhinitis. J Formos.Med Assoc. 2010;109(12):879-885. PubMed
  23. Yang, Y., Zhao, Y., Wang, C. S., Wang, X. D., and Zhang, L. [Prevalence of sensitization to aeroallergens in 10 030 patients with allergic rhinitis]. Zhonghua Er.Bi Yan.Hou Tou.Jing.Wai Ke Za Zhi 2011;46(11):914-920.
  24. Davies, M. G. and Kersey, P. J. Contact allergy to yarrow and dandelion. Contact Dermatitis 1986;14(4):256-257. PubMed
  25. Collins JM and Miller DR. Dandelion green bezoar following antrectomy and vagotomy - case report. J Kansas Med Soc 1966;67(6):303-304.
  26. Moriarty B, Pinney JH, Owen-Casey MP, Rustin MH, Deroide F, Laing C, Davenport A. Digital necrosis from dandelion tea. Br J Dermatol. 2013 Jul;169(1):227-30. PubMed
  27. Onal S, Timur S, Okutucu B, Zihnioglu F. Inhibition of alphaglucosidase by aqueous extracts of some potent antidiabetic medicinal herbs. Prep Biochem Biotechnol 2005;35:29-36.

See these in context on the Dandelion monograph →

Coffee 175 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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