Natural Digestive Enzymes Ingredients & Drug Interactions
by Carlson
What is this page for?
First and foremost: checking Natural Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Natural Digestive Enzymes is a dietary supplement by Carlson with 4 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Natural Digestive Enzymes by Carlson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product has four active ingredients designed to support digestion. Protease breaks down proteins, lipase handles fats, and amylase works on carbohydrates — together they mimic the enzymes your pancreas normally produces.
Ox bile supports fat digestion and absorption. The product also contains several inactive ingredients — lactose monohydrate, dicalcium phosphate, microcrystalline cellulose, stearic acid, croscarmellose sodium, magnesium stearate, silicon dioxide, and an enteric coating to protect the enzymes as they travel through your stomach.
Does it work?
No specific claim
The evidence on these digestive enzymes is limited. For lipase specifically, the data we hold shows insufficient evidence to rate it for inflammatory bowel disease (IBD), dyspepsia (indigestion), or prematurity.
We don't have effectiveness ratings on file for protease, amylase, or ox bile in this product.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated in adults, though digestive upset or allergic reactions can happen — rarely, people exposed to proteolytic enzymes occupationally have developed allergic rhinitis or asthma. If you have serious digestive conditions, use this product only under medical guidance.
For pregnancy: the safety data on protease advises against use unless prescribed by your doctor. Lipase hasn't been well studied in pregnancy, so talk with your doctor before taking it.
For breastfeeding: protease and lipase both have limited safety data, so check with your healthcare provider first. We hold no pregnancy or breastfeeding data for amylase or ox bile.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we were unable to verify interaction data for amylase and ox bile.
Before taking this product, use the medication checker on this page to confirm none of your specific drugs interact with the ingredients listed, and discuss it with your pharmacist if you have questions.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. No medication interactions are currently documented, and safety information is well characterized.
If you're looking for general digestive support and have no serious gut conditions, this enzyme blend is usually tolerated well. If you're pregnant, breastfeeding, have inflammatory bowel disease, or take medications, talk with your doctor or pharmacist before starting — they can confirm it's right for your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Natural Digestive Enzymes, straight from the product label.
| Brand | Carlson |
|---|---|
| Barcode (UPC) | 088395066450 |
| Net contents | 500 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Nov 21, 2019 |
| DSLD ID | 209369 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Natural Digestive Enzymes by Carlson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Ox Bile | 34 mg | -- |
| Pancreatin Concentrate 4x | 340 mg | -- |
Other ingredients: Lactose Monohydrate, Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Enteric Coating
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Digestive aid #34
Potency & quality guaranteed An FDA regulated facility
FDA Statement of Identity
Dietary Supplement
Formulation
Supports a healthy digestive system
Gluten-free Sugar-free Preservative-free
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Directions: Take one tablet at mealtime, one to three times daily, or as recommended by your doctor. Do not chew tablets.
Storage
Keep bottle tightly closed. Store away from heat and moisture.
Formula
Carlson Natural Digestive Enzymes is a powerful formula to promote the utilization of food. Each tablet supplies protease, amylase, and lipase, the body's most powerful digestive enzymes.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Natural Digestive Enzymes by Carlson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Natural Digestive Enzymes by Carlson
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Lactose Monohydrate, Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Enteric Coating. These complete the product’s ingredient list but are not active constituents.
Natural Digestive Enzymes by Carlson Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Natural Digestive Enzymes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Natural Digestive Enzymes, from the product label.
Carlson
See all Carlson products- Name
- Carlson Division of J.R. Carlson Laboratories, Inc.
- City
- Arlington Heights
- State
- IL
- ZipCode
- 60004
- Phone Number
- 888-234-5656
- Web Address
- www.carlsonlabs.com
Natural Digestive Enzymes by Carlson: Common Questions
Does Natural Digestive Enzymes by Carlson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this during pregnancy?
Is this safe while breastfeeding?
What are these enzymes supposed to do?
Does this product actually work for indigestion or IBS?
Can this cause allergic reactions?
Is this product right for people with serious digestive conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Natural Digestive Enzymes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Natural Digestive Enzymes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Natural Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC