Ocular Pressure & Retina Defense Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Ocular Pressure & Retina Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Ocular Pressure & Retina Defense is a dietary supplement by Whitaker Nutrition with 2 active ingredients. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 394 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol French Maritime Pine extract, MirtoSelect Bilberry extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Ocular Pressure & Retina Defense by Whitaker Nutrition
Ask about any prescription or over-the-counter medication and we check it for interactions with Ocular Pressure & Retina Defense by Whitaker Nutrition — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Ocular Pressure & Retina Defense by Whitaker Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 2 active ingredients. Pycnogenol French Maritime Pine extract is derived from the bark of maritime pine trees and is used in supplements targeting eye and circulatory health.
MirtoSelect Bilberry extract comes from the fruit and is traditionally used to support vision and microcirculation. The inactive ingredients—microcrystalline cellulose, gelatin, magnesium stearate, stearic acid, and silica—are fillers and capsule materials that hold the actives together.
Does it work?
Not established
Maritime Pine extract shows possibly effective evidence for osteoarthritis and chronic venous insufficiency (reduced swelling and discomfort in the legs). For bilberry, the data we hold does not establish effectiveness for night vision or age-related macular degeneration; evidence on cognitive decline, atherosclerosis, high cholesterol, and venous insufficiency is insufficient to rate.
Neither ingredient has been shown to reduce eye pressure specifically in the data available to us.
How safe is it?
Well-documented data
Maritime Pine extract is generally well tolerated in studies, though long-term safety is not fully established; the most common side effects are gastrointestinal complaints, dizziness, and vertigo. Bilberry fruit is generally safe as food, but supplement-form evidence and long-term safety are limited; common effects include dark-colored stools, flatulence, and gastrointestinal discomfort.
Regarding pregnancy, Maritime Pine safety data is insufficient—the facts advise against it during pregnancy and breastfeeding. Bilberry is rated likely safe in pregnancy and lactation, though supplement-dose safety during breastfeeding is not detailed in our data.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel), diabetes medications, immunosuppressants, CYP2E1 substrates, or erlotinib (Tarceva). All carry Moderate-severity interaction risk with one or both actives in this formula.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're looking to support eye and vascular health and don't take blood thinners, diabetes medications, or immunosuppressants. If you're on any of those drugs—or any other prescription medication—talk with your doctor or pharmacist before starting it.
Pregnant or breastfeeding women should discuss Maritime Pine with their provider, since safety data is limited. The bilberry component is generally considered safe in those situations, but the combination warrants personalized advice.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 19, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Ocular Pressure & Retina Defense, straight from the product label.
| Brand | Whitaker Nutrition |
|---|---|
| Barcode (UPC) | 678829212494 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 19, 2021 |
| DSLD ID | 256826 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Ocular Pressure & Retina Defense by Whitaker Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pycnogenol French Maritime Pine extract | 0 NP | -- |
| MirtoSelect Bilberry extract | 0 NP | -- |
| Mirtogenol Proprietary Complex | 120 mg | -- |
Other ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Ocular Pressure & Retina Defense with Mirtogenol, shown to support healthy intraocular pressure and retinal health.
Formulation
Unconditionally guaranteed for purity and potency.
Doctor-formulated to support healthy intraocular pressure and retinal health
GF Gluten free
Storage
Store with cap tightly closed in a cool, dry place.
Brand IP Statement(s)
Mirtogenol is a registered trademark of Horphag Research and Indena and is protected by international and pending patents. Mirtoselect is a registered trademark of Indena S.p.A. Pycnogenol is a registered trademark of Horphag Research Ltd.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Doctor’s Suggested Use: Take 1 capsule daily. For additional support, take 1 capsule twice daily.
Precautions
Precautions: This product is not a treatment for glaucoma.
Consult a health care practitioner before use if you are pregnant or nursing, have a serious medical condition, or use any medications.
Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Ocular Pressure & Retina Defense by Whitaker Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Ocular Pressure & Retina Defense by Whitaker Nutrition
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Mirtogenol Proprietary Complex
Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Magnesium Stearate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
Ocular Pressure & Retina Defense by Whitaker Nutrition Drug Interactions
HelloPharmacist Interaction Report
Ocular Pressure & Retina Defense by Whitaker Nutrition contains two active ingredients—Pycnogenol French Maritime Pine extract and MirtoSelect Bilberry extract—both of which interact with medications.
The most serious interaction is a Moderate-severity risk of bleeding when either ingredient is combined with blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel), since both can slow clotting.
Read the full breakdown — every affected drug type, severity by severity
Beyond bleeding risk, Maritime Pine may lower blood sugar when used with diabetes medications, requiring close blood glucose monitoring and possible dose adjustments. It may also reduce the effectiveness of immunosuppressants.
Bilberry carries similar diabetes-medication concerns and additionally may interfere with how your body metabolizes certain drugs processed through CYP2E1 enzymes—a group that includes some anesthetics and other medications. Bilberry also carries a theoretical risk of reducing the effectiveness of erlotinib (Tarceva), a cancer drug.
Both ingredients are well tolerated in studies, though long-term safety data for Maritime Pine is limited, and the bilberry extract evidence base is similarly sparse. Altogether, these interactions span 394 individual medications.
Before starting this product, check your complete medication list with your doctor or pharmacist, especially if you take blood thinners, diabetes medications, immunosuppressants, or any CYP2E1 substrates.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Ocular Pressure & Retina Defense?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Ocular Pressure & Retina Defense interact with 394 drugs. Click any drug to see the details.
2 of the 2 ingredients in Ocular Pressure & Retina Defense interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol French Maritime Pine extract MirtoSelect Bilberry extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Pycnogenol French Maritime Pine ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol French Maritime Pine Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Pycnogenol French Maritime Pine ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol French Maritime Pine Extract + Abciximab interactionMirtoselect Bilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Mirtoselect Bilberry Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Mirtoselect Bilberry Extract + Abrocitinib interactionPycnogenol French Maritime Pine ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol French Maritime Pine Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Pycnogenol French Maritime Pine ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol French Maritime Pine Extract + Acarbose interactionMirtoselect Bilberry ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Mirtoselect Bilberry Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Mirtoselect Bilberry Extract + Acenocoumarol interactionPycnogenol French Maritime Pine ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol French Maritime Pine Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Aspirin interactionPycnogenol French Maritime Pine ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol French Maritime Pine Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Ocular Pressure & Retina Defense — through 2 ingredients. Tap an ingredient for the detail:
Pycnogenol French Maritime Pine ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol French Maritime Pine Extract + Acetaminophen, Aspirin, Caffeine interactionMirtoselect Bilberry ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Ocular Pressure & Retina Defense — through 1 ingredient. Tap an ingredient for the detail:
Mirtoselect Bilberry ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Mirtoselect Bilberry Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Ocular Pressure & Retina Defense with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Pycnogenol French Maritime Pine extract
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
MirtoSelect Bilberry extract
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Ocular Pressure & Retina Defense, from the product label.
Whitaker Nutrition
See all Whitaker Nutrition products- Name
- Healthy Directions
- City
- Bethesda
- State
- MD
- ZipCode
- 20817
- Phone Number
- 1-800-722-8008
- Web Address
- healthydirections.com
Ocular Pressure & Retina Defense by Whitaker Nutrition: Common Questions
Does Ocular Pressure & Retina Defense by Whitaker Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Ocular Pressure & Retina Defense’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Maritime Pine
Interacts with 327 drugsMaritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...
Read the full Maritime Pine monograph → Herb & supplement monographBilberry
Interacts with 275 drugsBilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...
Read the full Bilberry monograph →Sources & How We Checked
Ocular Pressure & Retina Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Bilberry 14 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
- Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
- Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
- Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
- Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
- Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
- Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
- Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
- Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
- Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
- Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
- Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
- Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC