Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Oveeza Softgels Ingredients & Drug Interactions

by TriVue Pharmaceuticals

Oveeza Softgels label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Oveeza Softgels against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Oveeza Softgels is a dietary supplement by TriVue Pharmaceuticals with 6 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 469 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha Lipoic Acid, Coenzyme Q-10, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Oveeza Softgels by TriVue Pharmaceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Oveeza Softgels by TriVue Pharmaceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Oveeza Softgels by TriVue Pharmaceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (1,667 mcg DFE) without saying how much of each component you get.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (1,125 mg) without saying how much of each component you get.

Oveeza Softgels contains six active ingredients. The product includes eicosapentaenoic acid and docosahexaenoic acid—omega-3 fatty acids derived from fish oil—along with folic acid, vitamin B12, alpha-lipoic acid (an antioxidant), and coenzyme Q10 (a naturally occurring compound involved in cellular energy production).

The softgels also contain inactive ingredients: lecithin, beeswax, gelatin, glycerin, annatto extract, titanium dioxide, and purified water, which serve as binders, thickeners, and the capsule shell.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Folate deficiency — rated "Effective" (Folic Acid) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Coenzyme Q10 deficiency — rated "Likely Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Methotrexate toxicity — rated "Likely Effective" (Folic Acid) (Natural Medicines).

Evidence for these ingredients varies. Folic acid is rated effective for preventing folate deficiency and likely effective for preventing neural tube birth defects and reducing methotrexate toxicity; it's rated possibly effective for depression, certain gum conditions caused by seizure medications, and cognitive impairment.

Vitamin B12 is effective for B12 deficiency and is rated possibly effective for canker sores and nerve pain. Alpha-lipoic acid is rated possibly effective for diabetic nerve damage, high cholesterol, and weight management.

Coenzyme Q10 is rated likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraines, heart failure, and diabetic nerve damage. For the omega-3 fatty acids (eicosapentaenoic and docosahexaenoic acid), effectiveness data is not on file in our records.

The evidence, ingredient by ingredient Vitamin B12 Folic Acid Alpha-lipoic Acid Coenzyme Q10

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid at standard supplement doses is generally well tolerated; it's recommended during pregnancy at standard prenatal doses to help prevent birth defects and is considered safe while breastfeeding at normal recommended amounts. At higher doses (15 mg daily), it can cause altered sleep, vivid dreams, confusion, and hyperactivity.

Large doses may also worsen nerve damage in people deficient in vitamin B12. Vitamin B12 is generally very safe with no established upper limit and is needed in pregnancy and breastfeeding at recommended amounts.

Alpha-lipoic acid is generally well tolerated but can lower blood sugar and should be used under medical guidance; safety data during pregnancy and breastfeeding is insufficient, so it's best to avoid unless your doctor advises otherwise. Coenzyme Q10 is generally well tolerated; the most common side effects are gastrointestinal (appetite loss, diarrhea, nausea) in less than 1% of users.

Safety during pregnancy is not well established, so it's best to avoid unless advised by your doctor; safety while breastfeeding has not been well studied.

Side effects, ingredient by ingredient Vitamin B12 Folic Acid Alpha-lipoic Acid Coenzyme Q10

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Alpha-lipoic Acid, Vitamin B12, Coenzyme Q10, Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 469 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Oveeza Softgels, double-check with your doctor or pharmacist if you take seizure medications (phenobarbital, phenytoin, primidone), blood thinners or antiplatelet drugs (including warfarin), chemotherapy agents (methotrexate, capecitabine, 5-fluorouracil, alkylating agents, or antitumor antibiotics), thyroid hormones, diabetes medications, or metformin. These are the medication types with documented moderate or minor interactions with ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Oveeza Softgels may be worth considering if you're looking to support folate and B12 status or explore omega-3, alpha-lipoic acid, or coenzyme Q10 supplementation. However, be especially cautious if you take seizure medications, blood thinners, diabetes drugs, thyroid hormones, or chemotherapy—these warrant a careful check with your own doctor or pharmacist before starting.

Pregnant or breastfeeding individuals should also confirm suitability with their healthcare provider before use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Oveeza Softgels, straight from the product label.

Brand TriVue Pharmaceuticals
Barcode (UPC) 373480-404-300
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 264303
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Oveeza Softgels by TriVue Pharmaceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
15
UPC/BARCODE
373480-404-300
IngredientAmount% DV
Eicosapentaenoic Acid600 mg--
Docosahexaenoic Acid450 mg--
Folic Acid1 mg--
Vitamin B12500 mcg20834%
Folate1667 mcg DFE417%
Alpha Lipoic Acid100 mg--
Total Omega-3 Fatty Acids1125 mg--
Coenzyme Q-10100 mg--

Other ingredients: Lecithin, Beeswax, Gelatin, Glycerin, Annatto extract, Titanium Dioxide, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Dosage: Usual adult dose is 1-2 softgels once daily with a meal, or as prescribed by a licensed medical practitioner.

Precautions

If you are pregnant or nursing, ask a healthcare professional.

Keep out of reach of children

Contains: fish and soy

Storage

Storage: Store at 20 degrees - 25 degrees Celsius (68 degrees - 77 degrees Fahrenheit); excursions permitted to 15 degrees - 30 degrees Celsius (59 degrees - 86 degrees Fahrenheit) [See USP Controlled Room Temperature.]

Formulation

Made in Canada

General Statements

73480-404-30

Dispensed by prescription

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Oveeza Softgels by TriVue Pharmaceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Oveeza Softgels label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Oveeza Softgels by TriVue Pharmaceuticals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
500 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Folate

1667 mcg DFE per serving Form: Folic Acid

Alpha Lipoic Acid

Interacts with
263 drugs
100 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha Lipoic Acid monograph & interactions

Total Omega-3 Fatty Acids

1125 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid

Coenzyme Q-10

Interacts with
198 drugs
100 mg per serving Form: Ubiquinone

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q-10 monograph & interactions

Other (inactive) ingredients: Lecithin, Beeswax, Gelatin, Glycerin, Annatto extract, Titanium Dioxide, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Oveeza Softgels by TriVue Pharmaceuticals Drug Interactions

Want to check YOUR meds against Oveeza Softgels?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
469Drugs
216 Moderate 253 Minor

Ingredients driving the most interactions

Alpha Lipoic Acid 263
Coenzyme Q-10 198
Folic Acid 40
Vitamin B12 20

Individual Drug Interactions

The ingredients in Oveeza Softgels interact with 469 drugs. Click any drug to see the details.

4 of the 6 ingredients in Oveeza Softgels interact with drugs. Each result below shows which ingredient is responsible. Alpha Lipoic Acid Coenzyme Q-10 Folic Acid Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Oveeza Softgels with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha Lipoic Acid full monograph & interactions

Coenzyme Q-103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
Coenzyme Q-10 full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Oveeza Softgels, from the product label.

TriVue Pharmaceuticals

See all TriVue Pharmaceuticals products
Name
TriVue Pharmaceuticals, Inc.
City
Birmingham
State
AL
ZipCode
35235
Pharmacist Counseling Corner

Oveeza Softgels by TriVue Pharmaceuticals: Common Questions

Does Oveeza Softgels by TriVue Pharmaceuticals interact with any medications?
Yes. Based on its ingredients, Oveeza Softgels has a known interaction with 469 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Oveeza Softgels contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Oveeza if I'm trying to get pregnant or already pregnant?
Folic acid in this product is recommended during pregnancy at standard prenatal doses to help prevent birth defects and is considered safe. However, alpha-lipoic acid has insufficient safety data in pregnancy and is best avoided unless your doctor advises otherwise. Talk with your doctor or pharmacist about whether this product is right for you at this stage.
Will this help with my nerve pain from diabetes?
Both alpha-lipoic acid and coenzyme Q10 are rated possibly effective for diabetic nerve damage. However, alpha-lipoic acid can lower blood sugar, so it's best used under medical guidance if you have diabetes or take diabetes medications. Check with your doctor before starting.
What are the omega-3s in this product for?
This product contains eicosapentaenoic acid and docosahexaenoic acid, which are omega-3 fatty acids commonly used for general cardiovascular and metabolic support. We don't have specific effectiveness data on file for these particular forms in this product.
Can I take Oveeza if I'm on metformin for diabetes?
Vitamin B12 in this product has a minor interaction with metformin—metformin can lower B12 levels over time. Taking a B12 supplement like this one may help offset that. Still, check with your doctor to make sure the dose is right for you and to monitor your levels if needed.
Are there any common side effects I should expect?
At standard doses, folic acid and vitamin B12 are generally well tolerated. Alpha-lipoic acid may cause headache, heartburn, or nausea in some people. Coenzyme Q10 may cause mild gastrointestinal side effects like nausea or diarrhea in less than 1% of users. If you experience unusual symptoms, talk with your pharmacist.
Can I take this while breastfeeding?
Folic acid and vitamin B12 are considered safe at recommended amounts while breastfeeding. Alpha-lipoic acid has insufficient safety data, so it's best to avoid unless your doctor advises otherwise. Coenzyme Q10 safety while breastfeeding has not been well studied, so check with your doctor before use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Oveeza Softgels label
Go deeper

The Full Monographs Behind Oveeza Softgels’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph →
Sources

Sources & How We Checked

Oveeza Softgels's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 174 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
  9. Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
  11. Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
  12. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  13. Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
  14. Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
  15. Suitor CW, Bailey LB. Dietary folate equivalents: interpretation and application. J Am Diet Assoc 2000;100:88-94. PubMed
  16. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  17. Sandoval M, Charbonnet RM, Okuhama NN, et al. Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection. Free Radic Biol Med 2000;29:71-78.
  18. Antony AC. Megaloblastic Anemias. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone 2000: 451-79.
  19. Reynolds EH. Neurological aspects of folate and vitamin B12 metabolism. Clin Haematol 1976;5:661-96. DOI
  20. Reynolds EH. Folate metabolism and anticonvulsant therapy. Proc R Soc Med 1974;67:68.
  21. Ortiz Z, Shea B, Suarez Almazor M, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis (Cochrane Review). Cochrane Database Syst Rev 2000;2:CD000951. PubMed
  22. Van Delden C, Hirschel B. Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome (letter). J Infect Dis 1996;173:1294-5. PubMed
  23. Schroder H, Clausen N, Ostergard E, Pressler T. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Ped Hematol Oncol 1986;3:241-7. PubMed
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Alpha-lipoic Acid 48 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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