Pancreatin 1000 mg Ingredients & Drug Interactions
by NaturesPlus
What is this page for?
First and foremost: checking Pancreatin 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pancreatin 1000 mg is a dietary supplement by NaturesPlus with 3 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Pancreatin 1000 mg by NaturesPlus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Pancreatin 1000 mg contains 3 active digestive enzymes: lipase (breaks down fat), amylase (breaks down carbohydrates), and protease (breaks down protein). The remaining ingredients are inactive — microcrystalline cellulose, di-calcium phosphate, cellulose, stearic acid, magnesium stearate, carob, and pharmaceutical glaze — which are fillers, binders, and capsule materials.
Does it work?
No specific claim
The evidence for these enzymes isn't established in the data we hold. Lipase has been studied for inflammatory bowel disease and indigestion (dyspepsia), but the research so far is insufficient to rate whether it works for either one.
Protease has no effectiveness ratings on file. If you're considering this for a specific digestive concern, your doctor or pharmacist can help you weigh what the broader research shows.
How safe is it?
Well-documented data
Lipase and protease are generally well tolerated in most adults, though digestive upset or allergic reactions are possible with protease. The safety information on amylase isn't on file.
In rare cases, exposure to proteolytic enzymes (including protease) through occupational inhalation has triggered allergic rhinitis or asthma, but this applies to workplace exposure rather than oral supplements. A note: recombinant human bile salt-stimulated lipase — a lab-made form used in premature infant formulas — has caused serious gastrointestinal problems including a slightly higher rate of necrotizing enterocolitis in that vulnerable group; this product is not that form, but it underscores why people with serious digestive conditions should use enzyme supplements only under medical guidance.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. This doesn't guarantee none exist — it means they haven't been identified in available research.
Use the search tool on this page to verify your specific medications, and confirm with your doctor or pharmacist before starting.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure marketed for general wellness rather than one specific gradeable purpose. No medication interactions are currently documented, and safety information is well characterized.
Pancreatin 1000 mg supplies three digestive enzymes with no documented interactions in our data, though the evidence for how well they work isn't firmly established. It's generally well tolerated, but people with serious digestive conditions should only use it under medical supervision.
If you're pregnant, breastfeeding, or take any medications, check with your doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pancreatin 1000 mg, straight from the product label.
| Brand | NaturesPlus |
|---|---|
| Barcode (UPC) | 097467043800 |
| Net contents | 60 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 298734 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), No Allergies, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pancreatin 1000 mg by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lipase | 0 NP | -- |
| Amylase | 0 NP | -- |
| Pancreatin | 1000 mg | -- |
| Protease | 0 NP | -- |
Other ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Cellulose, Stearic Acid, Magnesium Stearate, Carob, Pharmaceutical Glaze
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Free from artificial colors and preservatives. Free from all of the major allergens identified in the U.S. Food Allergen Labeling and Consumer Protection Act.
Gluten free
Digestive Support
Specially coated to provide release of the Pancreatic Enzyme in the intestines.
Storage
Keep tightly closed in a cool, dry place.
Precautions
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
Copyright Natural Organics
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: One tablet daily, as symptoms occur.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pancreatin 1000 mg by NaturesPlus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pancreatin 1000 mg by NaturesPlus
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Cellulose, Stearic Acid, Magnesium Stearate, Carob, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.
Pancreatin 1000 mg by NaturesPlus Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Pancreatin 1000 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Pancreatin 1000 mg, from the product label.
NaturesPlus
See all NaturesPlus products- Name
- Natural Organics Laboratories, Inc. makers of NaturesPlus
- Street Address
- 9500 New Horizons Blvd.
- City
- Amityville
- State
- New York
- ZipCode
- 11701
- Web Address
- www.naturesplus.com
Pancreatin 1000 mg by NaturesPlus: Common Questions
Does Pancreatin 1000 mg by NaturesPlus interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What do these three enzymes do?
Is there evidence this product actually works?
Can I take this if I'm pregnant?
What side effects might I notice?
Will this interfere with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pancreatin 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pancreatin 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph →Sources & How We Checked
Pancreatin 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC