Pancreatin 2000 Ingredients & Drug Interactions
by NOW
What is this page for?
First and foremost: checking Pancreatin 2000 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pancreatin 2000 is a dietary supplement by NOW with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Pancreatin 2000 by NOW
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Pancreatin 2000 contains three active enzymes that break down food: amylase (digests carbohydrates), protease (breaks down proteins), and lipase (breaks down fats). These are the key ingredients in the capsule.
The product also includes microcrystalline cellulose, gelatin, medium-chain triglyceride powder, and silicon dioxide as inactive ingredients to hold the capsule together and keep it stable.
Does it work?
Not established
The evidence for these enzymes in treating digestive complaints or inflammatory bowel disease is insufficient in the data we hold. Lipase alone has been studied for dyspepsia (indigestion) and inflammatory bowel disease, but the evidence isn't strong enough to call it effective for those purposes.
If you're considering this product to help with a specific digestive condition, talk with your doctor about whether it makes sense for your situation.
How safe is it?
Well-documented data
Protease and lipase are generally well tolerated for most adults, though some people report mild digestive upset or allergic reactions. Protease can occasionally trigger allergic responses, especially with repeated or airborne exposure—this is rare but has happened in occupational settings.
Lipase is generally well tolerated, but people with serious digestive conditions should use it only under medical guidance. During pregnancy, protease safety hasn't been established and should be avoided unless your doctor prescribes it.
Lipase has little safety data in pregnancy, so use only if your doctor advises it. For breastfeeding, both ingredients have limited safety data—check with your healthcare provider first before using this product if you're nursing.
No safety data is on file for amylase.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, amylase could not be checked.
Use the medication search tool on this page to run through your exact medications, and let your doctor or pharmacist know you're considering this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Pancreatin 2000 is a straightforward digestive enzyme blend that's generally well tolerated in adults without documented drug interactions. It may help with nutrient breakdown, though the evidence for treating specific digestive complaints is weak in the studies we hold.
If you're pregnant, breastfeeding, or have a serious digestive condition, talk it over with your doctor or pharmacist before starting—they can tell you whether it's right for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pancreatin 2000, straight from the product label.
| Brand | NOW |
|---|---|
| Barcode (UPC) | 733739029461 |
| Net contents | 250 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2024 |
| DSLD ID | 315736 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pancreatin 2000 by NOW, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Pancreatin | 200 mg | -- |
Other ingredients: Microcrystalline Cellulose, Gelatin, Medium Chain Triglyceride, Powder, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Usage: Take 1 capsule 1 to 3 times daily with or between meals.
Formula
Pancreatin is a preparation of porcine pancreatic enzymes. Pancreatin has naturally occurring protease (protein digesting), amylase (carbohydrate digesting), and lipase (fat digesting) enzymes.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Caution: For adults only. Keep out of reach of children.
Consult physician if pregnant/nursing, taking medication, or have a medical condition.
MCT from coconut/palm kernel oil.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Digestive Support Assists Protein, Fat and Carbohydrate Digestion
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or sesame ingredients.
Made and quality tested in the USA with globally sourced ingredients.
Storage
Store in a cool, dry place after opening.
Seals/Symbols
GMP Quality Assured
FDA Statement of Identity
A Dietary Supplement
General Statements
Digestive Family owned since 1968.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pancreatin 2000 by NOW label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pancreatin 2000 by NOW
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container250 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Other (inactive) ingredients: Microcrystalline Cellulose, Gelatin, Medium Chain Triglyceride, Powder, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Pancreatin 2000 by NOW Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Pancreatin 2000. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Pancreatin 2000, from the product label.
NOW
See all NOW products- Name
- NOW Foods
- Street Address
- 395 S. Glen Ellyn Rd.
- City
- Bloomingdale
- State
- IL
- ZipCode
- 60108
- Web Address
- nowfoods.com
Pancreatin 2000 by NOW: Common Questions
Does Pancreatin 2000 by NOW interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does each enzyme in Pancreatin 2000 do?
Can I take this while pregnant?
Is it safe to breastfeed while taking Pancreatin 2000?
Will this help with my indigestion or IBS?
Could I have an allergic reaction to this?
Does this product contain fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pancreatin 2000 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pancreatin 2000’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Proteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
Pancreatin 2000's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC