No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Pharmaceutical Grade AjiPure L-Histidine 500 mg Ingredients & Drug Interactions

by Swanson Ultra

Capsule Category: Amino Acid/protein
No known interaction
The interaction bottom line No known interaction

Pharmaceutical Grade AjiPure L-Histidine 500 mg is a dietary supplement by Swanson Ultra with 1 active ingredient. Its ingredients are commonly taken for skin conditions like eczema, anemia related to kidney disease, allergy and inflammation support.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-Histidine, an amino acid your body needs to build and repair proteins. Each capsule delivers 500 mg of the pharmaceutical-grade form.

The inactive ingredients are cellulose (a plant-based capsule material) and rice flour, which help make the supplement easy to take.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Histidine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Histidine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cholera — rated "Possibly Effective" (Natural Medicines).

L-Histidine shows possibly effective evidence for cholera. For atopic dermatitis (eczema), kidney failure, and rheumatoid arthritis (RA), the evidence is too sparse or inconsistent to rate whether it works—there just isn't enough reliable data yet to say yes or no.

The evidence, ingredient by ingredient Histidine

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Histidine from food is likely safe as part of normal eating, but the safety of supplement doses this high hasn't been well studied. The product facts caution against taking supplement doses unless your doctor advises it.

There are no adverse effects documented in the trial data. In pregnancy and lactation, L-Histidine is rated likely safe.

Side effects, ingredient by ingredient Histidine

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for L-Histidine. Still, if you're on any medications and want to be sure, ask your doctor or pharmacist to review your specific drugs before you start.

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and some safety-information gaps remain.

This is a straight L-Histidine supplement—no extra ingredients, no interactions documented. It may help with cholera, though the evidence is limited.

If you're considering it for eczema, kidney issues, or rheumatoid arthritis, talk it over with your doctor or pharmacist first, since the evidence there isn't established. Because supplement doses of L-Histidine haven't been thoroughly studied for safety, check with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pharmaceutical Grade AjiPure L-Histidine 500 mg, straight from the product label.

Brand Swanson Ultra
Barcode (UPC) 087614024790
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 184952
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veggie Capsule(s)
Maximum serving Sizes:
1 Veggie Capsule(s)
UPC/BARCODE
087614024790
IngredientAmount% DV
L-Histidine500 mg--

Other ingredients: Cellulose, Rice Flour, May contain one or more of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The Most Advanced Nutrition Technology Veg caps

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

Seals/Symbols

AjiPure Amino Acids V Vegetarian formula

Formulation

V Vegetarian formula

FDA Statement of Identity

Dietary Supplement

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one veggie capsule per day with water.

General

SWU479 Rev 1 02 15 18

Brand IP Statement(s)

AjiPure and the AjiPure logo are registered trademarks of Ajinomoto, Inc.

See for yourself

Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veggie Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Histidine

No known
interactions
500 mg per serving

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from...

L-Histidine monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Flour, May contain one or more of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Pharmaceutical Grade AjiPure L-Histidine 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Pharmaceutical Grade AjiPure L-Histidine 500 mg, from the product label.

Swanson Ultra

See all Swanson Ultra products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra: Common Questions

Does Pharmaceutical Grade AjiPure L-Histidine 500 mg by Swanson Ultra interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Pharmaceutical Grade AjiPure L-Histidine 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Pharmaceutical Grade AjiPure L-Histidine 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-Histidine safe to take if I'm pregnant or breastfeeding?
L-Histidine is rated likely safe in pregnancy and lactation. That said, because supplement doses haven't been extensively studied, talk with your doctor or pharmacist before adding it to your routine while pregnant or nursing—they know your full health picture.
What does L-Histidine actually do?
L-Histidine is an amino acid your body uses to build and repair proteins. The evidence shows it may help with cholera, but for other conditions like eczema and rheumatoid arthritis, there isn't enough reliable data yet to say whether it works.
Why does the label say to avoid this unless my doctor says I should take it?
While dietary amounts of L-Histidine are part of normal eating, the safety of supplement doses this high hasn't been well established through rigorous testing. That's why the caution: talk with your doctor before starting, so they can decide if it's right for you.
Does this supplement have any fillers?
The inactive ingredients are cellulose (the capsule material) and rice flour. These are excipients that help deliver the L-Histidine—standard stuff you'll see in most capsules.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pharmaceutical Grade AjiPure L-Histidine 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pharmaceutical Grade AjiPure L-Histidine 500 mg label
Go deeper

The Full Monographs Behind Pharmaceutical Grade AjiPure L-Histidine 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Pharmaceutical Grade AjiPure L-Histidine 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring