Interactions on record — worth a quick check against your medications. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Plant-Based Support Collagen Builder Ingredients & Drug Interactions

by ResVitale

Plant-Based Support Collagen Builder label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Plant-Based Support Collagen Builder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Plant-Based Support Collagen Builder is a dietary supplement by ResVitale with 7 active ingredients. Its ingredients are commonly taken for sleep quality and insomnia, relaxation, cognitive function.Based on those ingredients, 214 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin C, Bamboo extract, Glycine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Plant-Based Support Collagen Builder by ResVitale

Ask about any prescription or over-the-counter medication and we check it for interactions with Plant-Based Support Collagen Builder by ResVitale — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Plant-Based Support Collagen Builder by ResVitale

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 7 active ingredients.
  • “Amino Acid Blend” is a proprietary blend — the label gives one combined amount (100 mg) without saying how much of each component you get.

ResVitale's Plant-Based Support Collagen Builder contains 7 active ingredients: glycine, lysine, proline, an amino acid blend, vitamin C, bamboo extract, and white tea extract. Glycine, lysine, and proline are amino acids — the building blocks your body uses to make collagen and connective tissue.

Vitamin C supports collagen formation and acts as an antioxidant. Bamboo extract and white tea extract add additional plant compounds, though the specific roles aren't detailed in the product facts.

The capsules also contain inactive ingredients (vegetable cellulose, vegetable capsule, rice bran, and silica) that serve as the capsule material and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support collagen synthesis and skin health.
  • We looked for evidence on: Aging skin, Atrophic acne scars, Laser skin resurfacing, skin elasticity, skin texture, connective tissue health — and 1 related terms.
  • The strongest evidence on file: Vitamin C is rated "Possibly Effective" for Laser skin resurfacing (Natural Medicines).
  • Also on file: Vitamin C is rated "Insufficient Reliable Evidence To Rate" for Acne, Aging skin, Atrophic acne scars, Wound healing.
  • Also on file: Glycine is rated "Insufficient Reliable Evidence To Rate" for Wound healing, Aging.

The evidence for effectiveness varies by ingredient. Glycine shows possibly effective evidence for schizophrenia support, though its role in collagen building isn't established in the data we hold.

Lysine is possibly effective for cold sores but has insufficient evidence for wound healing and bone health. Proline, bamboo extract, and white tea extract all lack established evidence in the data we hold — their effectiveness ratings show insufficient reliable evidence.

Vitamin C is effective for preventing vitamin C deficiency and possibly effective for anemia, cataracts, and certain respiratory infections, but specific evidence for collagen support isn't listed. In short, the collagen-building claims rest mainly on amino acids and vitamin C working together, but the clinical evidence directly supporting this product for that purpose isn't detailed in our data.

The evidence, ingredient by ingredient Glycine Lysine Proline Vitamin C Bamboo

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glycine is generally well tolerated at typical doses, though long-term safety data are limited. Rare side effects include mild sedation, irritability, insomnia, soft stools, nausea, and dry mouth.

Lysine is also generally well tolerated orally, but high amounts may cause stomach upset; common adverse effects include abdominal pain, diarrhea, and indigestion. Proline is considered low-risk from food sources, but supplement safety hasn't been well studied.

Vitamin C is well tolerated at normal dietary and supplement doses; side effects above 2 grams daily may include abdominal cramps, heartburn, osmotic diarrhea, nausea, and kidney stones in susceptible people. Bamboo extract from properly cooked or processed shoots is safe, but raw shoots contain cyanide compounds and concentrate forms carry unestablished risk.

For pregnancy, vitamin C at recommended dietary amounts is considered likely safe, but high-dose supplements should be avoided without your doctor's approval. Glycine, lysine, proline, and bamboo extract have insufficient data or caution is advised — talk with your doctor or pharmacist before taking this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Glycine Lysine Proline Vitamin C Bamboo

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Lysine, Bamboo, Vitamin C, Glycine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments.
  • For scale: 214 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take clozapine (an antipsychotic), oral estrogens or hormone replacement therapy, warfarin or other blood thinners, thyroid medication like levothyroxine, antithyroid drugs, chemotherapy drugs, or antitumor antibiotics — these carry Moderate interactions. Also mention any 5-HT4 agonists (Minor interaction), aluminum supplements, and any antipsychotic medications you're on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Plant-Based Support Collagen Builder may appeal to people seeking amino acid and vitamin support for connective tissue, though clinical evidence directly tied to collagen building isn't established in the data we hold. If you take clozapine, warfarin, thyroid medication, antithyroid drugs, chemotherapy, or estrogen-based birth control or hormone therapy, you should check your exact medications with your doctor or pharmacist before starting this product — vitamin C and other ingredients carry documented interactions with these drug types.

Talk it over with your own healthcare provider to make sure it fits your health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Plant-Based Support Collagen Builder, straight from the product label.

Brand ResVitale
Barcode (UPC) 858830002318
Net contents 60 Veggie Capsule(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79430
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Plant-Based Support Collagen Builder by ResVitale, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
30
UPC/BARCODE
858830002318
IngredientAmount% DV
Glycine0 NP--
Lysine0 NP--
Proline0 NP--
Amino Acid Blend100 mg--
Vitamin C60 mg100%
Bamboo extract100 mg--
White Tea extract100 mg--
Ceramosides Ceramide Wheat extract30 mg--

Other ingredients: Vegetable Cellulose, Vegetable Capsule, Rice Bran, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Collagen production and hydration decrease with age.

Ceramoside clinical trial participants reported they began to see visible results starting in two weeks.

Formulation

Plant-Based Support Collagen Builder is a vegan-friendly formula that provides nutrients to help support pre-collagen synthesis.

Vegan

Gluten free.

Wheat has been processed to allow the Ceramosides Ceramide to meet the FDA requirement for a Gluten-Free claim.

Formula

It includes co-nutrients including amino acids, vitamin C and silica.

Proprietary Ceramosides with pro-collagen nutrients & vitamin C

Contains wheat.

Brand IP Statement(s)

Plus, Ceramosides help promote softer, smoother skin.

Ceramosides is the trademark of E.P.I. France Orgen-C is a registered trademark of Orgenetics, Inc.

Advanced skincare from within

Ceramosides help promote hydration for visible results starting in 2 weeks Ceramosides help hydrate skin for smoother, more supple skin

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 2 capsules daily, preferably with food or as recommended by your healthcare practitioner.

Storage

Best stored tightly in a cool, dry place.

Precautions

Warning: Keep out of reach of children and pets. Do not use if outer seal is broken or missing.

Warning: Keep out of reach of children and pets. Infants, children, pregnant or breastfeeding women should avoid using this product.

Infants, children, pregnant or breastfeeding women should avoid using this product. Please check with your healthcare professional if you are on medication or under a doctor's care.

Contains wheat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Gluten free

Vegan

FDA Statement of Identity

Dietary Supplement

General

VL1921 VA1920

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Plant-Based Support Collagen Builder by ResVitale label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Plant-Based Support Collagen Builder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Plant-Based Support Collagen Builder by ResVitale

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Amino Acid Blend

100 mg per serving

Vitamin C

Interacts with
207 drugs
60 mg per serving Form: organic Amla Berry

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...

Vitamin C monograph & interactions

Bamboo extract

Interacts with
5 drugs
100 mg per serving Form: Silica

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail,...

Bamboo extract monograph & interactions

White Tea extract

100 mg per serving Form: Catechins, Polyphenols

Ceramosides Ceramide Wheat extract

30 mg per serving Form: Digalactosyl Diglyceride, Glycosylceramides

Other (inactive) ingredients: Vegetable Cellulose, Vegetable Capsule, Rice Bran, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Plant-Based Support Collagen Builder by ResVitale Drug Interactions

Want to check YOUR meds against Plant-Based Support Collagen Builder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
214Drugs
107 Moderate 107 Minor

Ingredients driving the most interactions

Vitamin C 207
Bamboo extract 5
Glycine 1
Lysine 1

Individual Drug Interactions

The ingredients in Plant-Based Support Collagen Builder interact with 214 drugs. Click any drug to see the details.

4 of the 7 ingredients in Plant-Based Support Collagen Builder interact with drugs. Each result below shows which ingredient is responsible. Vitamin C Bamboo extract Glycine Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Plant-Based Support Collagen Builder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin C13 drug types · 207 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Aluminum

Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.

Likelihood Probable Evidence B
Antitumor Antibiotics

Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.

Likelihood Possible Evidence D
Estrogens

Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.

Likelihood Probable Evidence B
Fluphenazine (Prolixin)

Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.

Likelihood Possible Evidence D
Indinavir (Crixivan)

Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.

Likelihood Probable Evidence B
Warfarin (Coumadin)

High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.

Likelihood Possible Evidence D
Acetaminophen (Tylenol, Others)

High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.

Likelihood Probable Evidence B
Aspirin

Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.

Likelihood Possible Evidence B
Choline Magnesium Trisalicylate (Trilisate)

Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Niacin

Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Salsalate (Disalcid)

Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.

Likelihood Possible Evidence B
Vitamin C full monograph & interactions

Bamboo extract1 drug type · 5 drugs

Antithyroid Drugs

Theoretically, long-term bamboo use might increase the effects and adverse effects of antithyroid drugs, possibly leading to hypothyroidism.
Animal research suggests that long-term consumption of bamboo shoot can decrease thyroid peroxidase activity, as well as levels of thyroxine (T4) and triiodothyronine (T3). This effect has not yet been reported in humans.

Likelihood Possible Evidence D
Bamboo extract full monograph & interactions

Glycine1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine full monograph & interactions

Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Plant-Based Support Collagen Builder, from the product label.

ResVitale

See all ResVitale products
Name
ResVitale
Street Address
2255 Glades Rd., Suite 342W.
City
Boca Raton
State
FL
ZipCode
33431
Phone Number
1-877-787-5454
Web Address
www.resvitale.com
Pharmacist Counseling Corner

Plant-Based Support Collagen Builder by ResVitale: Common Questions

Does Plant-Based Support Collagen Builder by ResVitale interact with any medications?
Yes. Based on its ingredients, Plant-Based Support Collagen Builder has a known interaction with 214 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Plant-Based Support Collagen Builder contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have any ingredients I should avoid if I'm pregnant?
Vitamin C at normal dietary amounts is considered likely safe in pregnancy, but high-dose vitamin C supplements should be avoided without your doctor's approval. Glycine, lysine, proline, and bamboo extract don't have enough reliable data on supplemental doses during pregnancy — talk with your doctor or pharmacist before taking this product if you're pregnant to get personalized advice.
Can I take this if I'm breastfeeding?
There isn't enough reliable information on most of these ingredients while breastfeeding. Vitamin C at recommended dietary amounts is considered safe, but high-dose supplements should be avoided. Glycine, lysine, proline, and bamboo extract all carry caution because safety data are limited — check with your doctor or pharmacist before using this product.
What does glycine do in this formula?
Glycine is an amino acid — a building block your body uses to make collagen and other connective tissue. The specific evidence for glycine's role in collagen support isn't detailed in our data, though it shows possibly effective evidence for schizophrenia support.
Is this safe to take with my thyroid medication?
This product contains vitamin C, which can increase levothyroxine (Synthroid) absorption and alter your thyroid hormone levels. You'll need to check with your doctor or pharmacist — taking them together may require timing changes or dose adjustments to keep your thyroid medication working as intended.
What side effects might I notice?
Glycine rarely causes mild sedation or gastrointestinal upset. Lysine commonly causes abdominal pain, diarrhea, or indigestion at high doses. Vitamin C at doses above 2 grams daily may cause abdominal cramps, heartburn, diarrhea, nausea, or kidney stones in susceptible people. Most people tolerate these ingredients well at typical doses; side effects resolve quickly if you stop taking it.
Will this actually help build collagen?
The product contains amino acids (glycine, lysine, proline) and vitamin C, which your body uses to make collagen, but the data we hold doesn't include clinical evidence specifically testing whether this formula supports collagen building in people. The individual ingredients show some supportive evidence for related uses, but direct collagen-building claims aren't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Plant-Based Support Collagen Builder label
Go deeper

The Full Monographs Behind Plant-Based Support Collagen Builder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Proline

Proline is a non-essential amino acid that your body can make on its own and that you also get from protein-rich foods. It is a key building block of collagen, but strong human evidence that...

Read the full Proline monograph → Herb & supplement monograph

Vitamin C

Interacts with 207 drugs

Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...

Read the full Vitamin C monograph → Herb & supplement monograph

Bamboo

Interacts with 5 drugs

Bamboo is a giant grass whose shoots are eaten as food and whose leaves and silica-rich extracts are sold as supplements, often for hair, skin, nail, and bone support. Solid human evidence f...

Read the full Bamboo monograph →
Sources

Sources & How We Checked

Plant-Based Support Collagen Builder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glycine 5 references
  1. Heresco-Levy U, Javitt DC, Ermilov M, et al. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry 1999;56:29-36.. PubMed
  2. Potkin SG, Jin Y, Bunney BG, Costa J, Gulasekaram B. Effect of clozapine and adjunctive high-dose glycine in treatment-resistant schizophrenia. Am J Psychiatry 1999;156:145-7.. PubMed
  3. Gusev EI, Skvortsova VI, Dambinova SA, et al. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis 2000;10:49-60. PubMed
  4. Inagawa K, Kawai N, Ono K, Sukegawa E, Tsubuku S, Takahashi M. Assessment of acute adverse effects of glycine ingestion at a high dose in human volunteers. Seikatsu Eisei. 2006; 50:27-32.
  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Lysine 7 references
  1. Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. PubMed
  2. McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73.
  3. DiGiovanna JJ, Blank H. Failure of lysine in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Arch Dermatol 1984;120:48-51. DOI
  4. Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7.
  5. Griffith RS, Walsh DE, Myrmel KH, et al. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica 1987;175:183-90. DOI
  6. Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. PubMed
  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

Proline 4 references
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See these in context on the Proline monograph →

Vitamin C 51 references
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Bamboo 4 references
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See these in context on the Bamboo monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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