Probiotics Original Formula Ingredients & Drug Interactions
by Dr. Ohhira's
What is this page for?
First and foremost: checking Probiotics Original Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Probiotics Original Formula is a dietary supplement by Dr. Ohhira's with 6 active ingredients. Its ingredients are commonly taken for food and drink flavoring or sourness, preservative and acidity adjuster, kidney stone prevention (as citrate salts).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Probiotics Original Formula by Dr. Ohhira's
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Dr. Ohhira's Probiotics Original Formula contains 6 active ingredients: citric acid, lactic acid, acetic acid, formic acid, a proprietary organic acid blend, a proprietary fermented culture, and a proprietary lactic acid bacteria blend.
These work together as part of a fermented formula designed to deliver live cultures. The inactive ingredients are mountain spring water, safflower oil, beeswax, lecithin, and the capsule material itself.
There are no added fillers or preservatives beyond what's listed.
Does it work?
Couldn't assess
In our data, lactic acid is rated likely effective for dry skin. Citric acid and the other acids in the formula don't have established effectiveness ratings for common uses we track.
The fermented culture and lactic acid bacteria blend are part of what makes this a probiotic product, but we hold no effectiveness data for them in our monographs. If you're considering this for digestive or immune health, that evidence isn't included in the facts we have on file.
How safe is it?
Well-documented data
Citric acid and lactic acid are each rated likely safe in pregnancy and lactation at dietary levels. Both are generally well tolerated in foods and standard supplement doses.
Topically applied citric and lactic acid can cause mild irritation, sun sensitivity, and tingling in some people; at high concentrations or with prolonged contact, more serious irritation is possible—but these concerns apply mainly to concentrated topical products, not an oral capsule. We hold no safety data for acetic acid, formic acid, the fermented culture, or the lactic acid bacteria blend as used in this product.
If you have a history of severe acid sensitivity or gut issues, or if you're pregnant or breastfeeding and want extra reassurance, check with your doctor or pharmacist before starting.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, run your exact medications through the search tool on this page to be sure, and let your doctor or pharmacist know you're adding this if you're on any prescription drugs or have kidney issues.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Dr. Ohhira's Probiotics Original Formula shows no documented interactions with medications we could check.
It's generally well tolerated, and its lactic acid content is rated likely effective for dry skin. If you're on medications or have kidney concerns, a quick conversation with your doctor or pharmacist before starting is a good idea—mainly to confirm the formula fits your health picture, not because of a red flag.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 27, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Probiotics Original Formula, straight from the product label.
| Brand | Dr. Ohhira's |
|---|---|
| Barcode (UPC) | 695927121251 |
| Net contents | 60 Capsule(s); 36 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Oct 27, 2014 |
| DSLD ID | 38666 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Probiotics Original Formula by Dr. Ohhira's, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Citric Acid | 0 NP | -- |
| Lactic Acid | 0 NP | -- |
| Acetic Acid | 0 NP | -- |
| Formic Acid | 0 NP | -- |
| Proprietary Organic Acid Blend | 1.27 mg | -- |
| Proprietary Fermented Culture | 0.42 Gram(s) | -- |
| Proprietary Lactic Acid Bacteria Blend | 900000000 CFU | -- |
Other ingredients: mountain spring Water, Safflower Oil, Beeswax, Lecithin, Capsule, Lactic Acid Bacteria
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Refrigeration not required.
General Statements
PRODUCT OF JAPAN
COMPLETE PROBIOTIC SYSTEM WITH LIVE CULTURES NATURE'S WHOLE FOOD SUPPLEMENT
The Original Formula is fermented to three years using 12 strains of lactic acid bacteria (LAB) including TH10, Dr. Ohhira's proprietary LAB strain. The probiotics are encapsulated with their culture medium of nutritious fermented vegetables, fruits, mushrooms, and seaweed. This biogenic blend supplies a complete probiotic system including prebiotics, enzymes, micro-nutrients, and organic acids for a healthy digestive pH.
ABOX 031413 104256 01
Blister-packed to ensure product integrity.
Seals/Symbols
MULTI-YEAR WINNER MULTI-YEAR WINNER
Certified Vegetarian AVA American Vegetarian Association
MULTI-YEAR WINNER
FDA Statement of Identity
DIETARY SUPPLEMENT
Brand IP Statement(s)
It Takes Guts...(TM) Developed by award-winning microbiologist lichiroh Ohhira, Ph.D. and distinguished research scientists from Okayama University, Dr. Ohhira's Probiotics(R) combines ancient Japanese fermentation artistry with modern technology.
Dr. Ohhira's Probiotcs(R) supports the individual's own unique flora, and promotes healthy nutrient absorption, metabolism, and immune response.*
Dr. Ohhira's Probiotics(R) is a registered trademark of Essential Formulas(R).
FDA Disclaimer Statement
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Suggested Use: For best results take one (1) capsule twice a day on an empty stomach (1 hour before or 1 1/2 hours after meal) or as directed by your primary health care provider.
Precautions
Temporary reactions such as minor bloating or a mild laxative or constipating effect are signs the beneficial bacteria are remodeling, detoxifying, and improving the gut environment. If such transition effects last more than 10 days, consult your health care provider.
Keep out of reach of children.
If pregnant or nursing, ask a health professional before use.
Tamper evident: Do not use if foil blister pack is broken.
Contains fermented soy.
Formula
Contains fermented soy.
Formulation
Product does not contain milk, egg, fish, crustacean shellfish, tree nuts, wheat (gluten), peanuts or soybeans.
100% vegetarian
Contains no dairy or gluten. Non-GMO, Chemical-free.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Probiotics Original Formula by Dr. Ohhira's label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Probiotics Original Formula by Dr. Ohhira's
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Organic Acid Blend
- › Citric Acid
- › Lactic Acid
- › Acetic Acid
- › Formic Acid
Proprietary Fermented Culture
Proprietary Lactic Acid Bacteria Blend
Other (inactive) ingredients: Mountain spring Water, Safflower Oil, Beeswax, Lecithin, Capsule, Lactic Acid Bacteria. These complete the product’s ingredient list but are not active constituents.
Probiotics Original Formula by Dr. Ohhira's Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Probiotics Original Formula. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Probiotics Original Formula, from the product label.
Dr. Ohhira's
See all Dr. Ohhira's products- Name
- Essential Formulas Incorporated
- Street Address
- P.O. Box 166139
- City
- Irving
- State
- TX
- ZipCode
- 75016-6139
- Phone Number
- (972)-255-3918
- Web Address
- www.EssentialFormulas.com
Probiotics Original Formula by Dr. Ohhira's: Common Questions
Does Probiotics Original Formula by Dr. Ohhira's interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Dr. Ohhira's Probiotics safe to take while pregnant or breastfeeding?
What does lactic acid do in this formula?
Can I take this with my blood pressure medication (or other prescription drugs)?
Does this product have fillers?
How many live bacteria are in each capsule?
Is it safe to take this if I have kidney disease?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Probiotics Original Formula is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Probiotics Original Formula’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Citric Acid
Citric acid is a natural acid found in citrus fruits and is widely used as a safe food additive, flavoring, and preservative. In medicine, citrate forms (like potassium or sodium citrate) ar...
Read the full Citric Acid monograph → Herb & supplement monographLactic Acid
Lactic acid is a naturally occurring acid made by the body during exercise and by bacteria that ferment milk and other foods. It is most often used on the skin as an exfoliant and moisturize...
Read the full Lactic Acid monograph →Sources & How We Checked
Probiotics Original Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 31 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Citric Acid 10 references
- Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000). DOI
- Erbagci Z, Akcali C. Biweekly serial glycolic acid peels vs. long-term daily use of topical low-strength glycolic acid in the treatment of atrophic acne scars. Int J Dermatol 2000;39:789-94.. PubMed
- Ghadishah D, Gorchynski J. Airway compromise after routine alpha-hydroxy facial peel administration. J Emerg Med 2002;22:353-5.. PubMed
- Baumann LS, Oresajo C, Yatskayer M, Dahl A, Figueras K. Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment
- Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3 PubMed
- Kaminaka C, Uede M, Matsunaka H, Furukawa F, Yamomoto Y. Clinical evaluation of glycolic acid chemical peeling in patients with acne vulgaris: a randomized, double-blind, placebo-controlled, split-face comparative study. Dermatol Surg. 2014 Mar;40(3):314- PubMed
- Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4. PubMed
- Vachiramon V, Sahawatwong S, Sirithanabadeekul P. Treatment of melasma in men with low-fluence Q-switched neodymium-doped yttrium-aluminum-garnet laser versus combined laser and glycolic acid peeling. Dermatol Surg. 2015 Apr;41(4):457-65. PubMed
- US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
- Ormerod AD, van Voorst Vader PC, Majewski S, Vanscheidt W, Benjamin N, van der Meijden W. Evaluation of the efficacy, safety, and tolerability of 3 dose regimens of topical sodium nitrite with citric acid in patients with anogenital warts: A randomized cl DOI
Lactic Acid 21 references
- Kempers S, Katz HI, Wildnauer R, Green B. An evaluation of the effect of an alpha hydroxy acid-blend skin cream in the cosmetic improvement of symptoms of moderate to severe xerosis, epidermolytic hyperkeratosis, and ichthyosis. Cutis 1998;61:347-50.
- Stiller MJ, Bartolone J, Stern R, et al. Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind, vehicle-controlled clinical trial. Arch Dermatol 1996;132:631-6.
- Wehr R, Krochmal L, Bagatell F, Ragsdale W. A controlled two-center study of lactate 12 percent lotion and a petrolatum-based creme in patients with xerosis. Cutis 1986;37:205-7, 209.
- Kurtzweil P. Alpha-hydroxy acids for skin care: Smooth sailing or rough seas? FDA 1999. Available at: /www.fda.gov/fdac/features/1998/298_ahas.html (Accessed 18 August 2000). DOI
- Emtestam L, Svensson Å, Rensfeldt K. Treatment of seborrhoeic dermatitis of the scalp with a topical solution of urea, lactic acid, and propylene glycol (K301): results of two double-blind, randomised, placebo-controlled studies. Mycoses. 2012 Sep;55(5):3 PubMed
- Köse O, Özmen I, Arca E. An open, comparative study of 10% potassium hydroxide solution versus salicylic and lactic acid combination in the treatment of molluscum contagiosum in children. J Dermatolog Treat. 2013 Aug;24(4):300-4. PubMed
- Rogers RS 3rd, Callen J, Wehr R, Krochmal L. Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis. J Am Acad Dermatol 1989;21(4 Pt 1):714-6. PubMed
- Jennings MB, Logan L, Alfieri DM, Ross CF, Goodwin S, Lesczczynski C. A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis. J Am Podiatr Med Assoc 2002;92(3):143-8. PubMed
- Dahl MV, Dahl AC. 12% lactate lotion for the treatment of xerosis. A double-blind clinical evaluation. Arch Dermatol 1983;119(1):27-30. DOI
- Pham HT, Exelbert L, Segal-Owens AC, Veves A. A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48(5):30-6.
- Draelos ZD, Hall S, Munsick C. A 14-day Controlled Study Assessing Qualitative Improvement with 15% Lactic Acid and Ceramides in Skin Moisturization and Desquamation. J Clin Aesthet Dermatol 2020;13(8):E54-E58.
- Jennings MB, Alfieri D, Ward K, Lesczczynski C. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc 1998;88(7):332-6. PubMed
- Ademola J, Frazier C, Kim SJ, Theaux C, Saudez X. Clinical evaluation of 40% urea and 12% ammonium lactate in the treatment of xerosis. Am J Clin Dermatol 2002;3(3):217-22. PubMed
- Jennings MB, Alfieri DM, Parker ER, Jackman L, Goodwin S, Lesczczynski C. A double-blind clinical trial comparing the efficacy and safety of pure lanolin versus ammonium lactate 12% cream for the treatment of moderate to severe foot xerosis. Cutis 2003;71
- Uy JJ, Joyce AM, Nelson JP, West B, Montague JR. Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study. J Am Podiatr Med Assoc 1999;89(10):502-5. PubMed
- US Food and Drug Administration (FDA). Cosmetic Ingredients: Alpha Hydroxy Acids. August 2020. Available at: https://www.fda.gov/cosmetics/cosmetic-ingredients/alpha-hydroxy-acids. Accessed on October 19, 2021.
- Diebold R, Schopf B, Stammer H, Mendling W. Vaginal treatment with lactic acid gel delays relapses in recurrent urinary tract infections: results from an open, multicentre observational study. Arch Gynecol Obstet 2021;304(2):409-417. PubMed
- Khattar JA, Musharrafieh UM, Tamim H, Hamadeh GN. Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. Int J Dermatol 2007;46(4):427-30. PubMed
- Emtestam L, Kaaman T, Rensfeldt K. Treatment of distal subungual onychomycosis with a topical preparation of urea, propylene glycol and lactic acid: results of a 24-week, double-blind, placebo-controlled study. Mycoses 2012;55(6):532-40. PubMed
- Siskin SB, Quinlan PJ, Finkelstein MS, Marlucci M, Maglietta TG, Gibson JR. The effects of ammonium lactate 12% lotion versus no therapy in the treatment of dry skin of the heels. Int J Dermatol 1993;32(12):905-7. PubMed
- Robinson D, Friedmann D, Gordon J, Wortzman M, Nelson D. Efficacy and Tolerability of a Double-Conjugated Retinoid and Alpha Hydroxy Acid Cream in Subjects With Mild to Moderate Blemish-Prone Skin. J Drugs Dermatol 2022;21(1):54-59. DOI
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC