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Dietary supplement

Pumpkin Seed Extract Ingredients & Drug Interactions

by Nature's Answer

Pumpkin Seed Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pumpkin Seed Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pumpkin Seed Extract is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pumpkin (Cucurbita pepo) seed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pumpkin Seed Extract by Nature's Answer

Ask about any prescription or over-the-counter medication and we check it for interactions with Pumpkin Seed Extract by Nature's Answer — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pumpkin Seed Extract by Nature's Answer

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pumpkin (Cucurbita pepo) seed extract. The liquid formulation also includes purified water, vegetable glycerin, and 12-15% certified organic alcohol as inactive ingredients to preserve and deliver the extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Pumpkin's overall clinical evidence instead.

Moderate

Some clinical evidence supports Pumpkin for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Benign prostatic hyperplasia (BPH) — rated "Possibly Effective" (Natural Medicines).

Pumpkin seed extract is possibly effective for benign prostatic hyperplasia (BPH) — enlarged prostate that can affect urination in older men. For other conditions — androgenic alopecia (pattern hair loss), interstitial cystitis (chronic bladder pain), intestinal parasites, and urinary tract infections — the evidence we have is insufficient to rate whether it works.

If you're considering it for one of those uses, talk with your doctor about what the current evidence shows and whether it makes sense for your situation.

The evidence, ingredient by ingredient Pumpkin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin as a food is generally well tolerated. For concentrated seed supplements like this one, the safety data in adults is limited.

The most common side effects are abdominal discomfort, diarrhea, nausea, and vomiting. Very rarely, anaphylaxis (a serious allergic reaction) has been reported.

There are also two case reports of significant hair loss 1–3 weeks after consuming bitter-tasting pumpkin or squash with high levels of cucurbitacin (a natural compound in wild varieties), though this is uncommon. Safety during pregnancy and breastfeeding is not well studied for concentrated supplements, so talk with your doctor or pharmacist before using this product if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Pumpkin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium (Lithobid, Eskalith, or a generic form), you need to clear this product with your doctor or pharmacist first. Pumpkin seed extract may reduce how quickly your body clears lithium, raising levels in your blood.

Your dose might need adjustment, and your lithium levels may need to be monitored more closely.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Pumpkin seed extract may help with enlarged prostate symptoms, though evidence is limited for other uses. The main caution is lithium — if you take it for mood disorders, check with your doctor before starting this product.

Otherwise, it's generally well tolerated, though mild digestive upset can happen. Talk with your own doctor or pharmacist about whether this supplement fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pumpkin Seed Extract, straight from the product label.

Brand Nature's Answer
Barcode (UPC) 083000004780
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 239392
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pumpkin Seed Extract by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
15
UPC/BARCODE
083000004780
IngredientAmount% DV
Pumpkin (Cucurbita pepo) seed extract235 mg--

Other ingredients: purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Gluten Free

Gluten-Free Absolutely no preservatives

Our alcohol extracts are produced using our cold Bio-Chelated proprietary extraction process, yielding a Holistically Balanced Advanced Botanical Fingerprint extract in the same synergistic ratios as in the plant.

Promotes overall health & wellbeing

Seals/Symbols

K Parve (Kosher)

Bio-Chelated Cold Extraction Process

Formula

K Parve (Kosher)

Cucurbita pepo Made From 4000 mg Pumpkin Seeds per serving

Low Alcohol

General Statements

Nature's Answer since 1972

Discover Nature's Answer

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1-2 mL (28-56 drops) three (3) times a day in a small amount of water. Shake well.

Precautions

Keep out of reach of children.

Warning: Do not use if pregnant or nursing.

Do not use if safety seal is damaged or missing.

Brand IP Statement(s)

Copyright 2019 Nature's Answer

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pumpkin Seed Extract by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pumpkin Seed Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pumpkin Seed Extract by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Pumpkin (Cucurbita pepo) seed extract

Interacts with
1 drug
235 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin (Cucurbita pepo) seed extract monograph & interactions

Other (inactive) ingredients: Purified Water, Vegetable Glycerin, 12-15% certified organic Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pumpkin Seed Extract by Nature's Answer Drug Interactions

Want to check YOUR meds against Pumpkin Seed Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Pumpkin (Cucurbita pepo) seed extract 1

Individual Drug Interactions

The ingredients in Pumpkin Seed Extract interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Pumpkin Seed Extract interact with drugs. Each result below shows which ingredient is responsible. Pumpkin (Cucurbita pepo) seed extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pumpkin Seed Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pumpkin (Cucurbita pepo) seed extract1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin (Cucurbita pepo) seed extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pumpkin Seed Extract, from the product label.

Nature's Answer

See all Nature's Answer products
Name
Nature's Answer
Street Address
85 Commerce Drive
City
Hauppauge
State
NY
ZipCode
11788
Phone Number
(800) 439-2324
Web Address
www.naturesanswer.com
Pharmacist Counseling Corner

Pumpkin Seed Extract by Nature's Answer: Common Questions

Does Pumpkin Seed Extract by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Pumpkin Seed Extract has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pumpkin Seed Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my enlarged prostate?
Pumpkin seed extract is possibly effective for benign prostatic hyperplasia (BPH) based on available evidence. That's encouraging, but not a guarantee — results vary. Talk with your doctor about whether it's worth trying alongside other treatments he or she recommends.
What are the most common side effects?
Most people who take pumpkin products have no problems, but abdominal discomfort, diarrhea, nausea, and vomiting can happen. These are usually mild. Serious reactions like anaphylaxis are very rare.
Is it safe during pregnancy or breastfeeding?
The safety of concentrated pumpkin seed supplements during pregnancy and breastfeeding is not well studied. Eating pumpkin as a food is fine, but for a concentrated extract like this one, talk with your doctor or pharmacist to decide what's right for you.
Can I take this if I take other medications?
Use the medication checker on this page to search your exact drugs. The one major interaction we know about is with lithium — if you take that, check with your doctor first. For other medications, we don't have documented interactions, though that's not a guarantee none exist.
What does the alcohol content do?
The certified organic alcohol (12-15%) is part of the liquid formulation — it preserves the extract and helps deliver the active ingredient. If you need to avoid alcohol, mention this product to your pharmacist to discuss other options.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pumpkin Seed Extract label
Go deeper

The Full Monographs Behind Pumpkin Seed Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Pumpkin Seed Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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