Rest-ZZZ By LifeSeasons Overview & Drug Interactions

Valerian (Valeriana officinalis) is a perennial herb native to Europe and Asia. The plant is known for its strong, distinctive odor and its purported medicinal effects. Valerian contains a number of active compounds, including valerenic acid and valepotriates, which are believed to have a sedative effect on the body and are may to be helpful in the treatment of insomnia and anxiety. Valerian is also believed to have mild tranquilizing and muscle-relaxing properties and may be helpful in the treatment of muscle spasms and other muscle disorders. The root of the valerian plant is most commonly utilized in dietary supplements and is often standardized for valerenic acid content.

German chamomile (Matricaria recutita) is a plant species in the Asteraceae family and is native to Europe and Asia. German chamomile is a popular herbal remedy and is often used in teas, tinctures, and other preparations for its calming and digestive properties. German chamomile has Generally Recognized as Safe (GRAS) status in the United States.

Passionflower (Passiflora incarnata) is a climbing vine with fragrant white and purple flowers that is native to the Americas. It is purported to have a number of potential health benefits, including reducing anxiety and improving sleep. It is thought to work by increasing the levels of GABA (gamma-aminobutyric acid), a neurotransmitter in the brain that helps regulate mood and anxiety. Passionflower may also have mild sedative and muscle-relaxing effects and may be helpful in the treatment of muscle spasms and other muscle disorders. Dietary supplements containing passionflower are generally standardized to contain no less than 1.5% of the flavanoid vitexin.

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that is involved in a variety of functions, including regulating brain activity and behavior, relaxation, and sleep. GABA is endogenously produced in the brain from the amino acid glutamate and is responsible for inhibiting the activity of nerve cells in the brain and central nervous system. GABA is a popular dietary supplement and is used to help reduce anxiety and improve sleep, but more research is needed to determine its safety and effectiveness.

Hawthorn is a shrub native to Europe, Asia, and North America. It is a member of the rose family and is known for its thorny branches and small, white or pink flowers, which bloom in the spring. The fruit, called a haw, is a small red berry that is edible and often used in traditional medicine. Hawthorn has been used to treat a variety of conditions, including gastrointestinal discomfort, heart disease, high blood pressure, and chest pain. For its purported blood pressure-lowering abilities, it is thought to work by dilating blood vessels and improving blood flow to the heart. Hawthorn dietary supplements are typically standardized extracts of the berry, leaf and flower of the plant.

Melatonin is a hormone that is produced naturally in the pineal gland. It is involved in several different bodily processes, such as the regulation of the body's sleep-wake cycle. Melatonin is available as a dietary supplement and is often used to help people with sleep disorders, such as insomnia, fall asleep more easily. There is some evidence to suggest that melatonin supplements may be helpful in reducing the time it takes to fall asleep and improving sleep quality, although the results of studies on this topic have been mixed. Studies show better support for some specific conditions, such as Delayed sleep phase syndrome (DSPS) and Non-24-hour sleep-wake disorder. Melatonin is generally considered to be safe when used in the short term, although it can cause side effects in some people, such as dizziness, headache, and nausea. While melatonin is a natural hormone, it is often synthesized for its use in dietary supplements.