SIBOZyme Ingredients & Drug Interactions
by Priority One Nutritional Supplements
What is this page for?
First and foremost: checking SIBOZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
SIBOZyme is a dietary supplement by Priority One Nutritional Supplements with 9 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of SIBOZyme by Priority One Nutritional Supplements
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
SIBOZyme contains nine active ingredients: three carbohydrate-digesting enzymes (amylase, maltase, and sucrase), three protein and fat digesters (protease, lipase, and lactase), plus pancreatin (a blend of digestive enzymes from animal pancreas), ox bile (which helps break down fats), and Tolerase-G (an enzyme complex). The inactive ingredients are rice flour, silicon dioxide, gelatin, and purified water.
Does it work?
Strong evidence
The data we hold shows lactase is effective for lactose intolerance. For the other enzymes—protease, lipase, and the carbohydrate digesters—the evidence on file is insufficient to rate them.
Pancreatin, maltase, sucrase, ox bile, and Tolerase-G have no effectiveness ratings in our data.
How safe is it?
Well-documented data
Protease, lipase, and lactase are generally well tolerated in adults, though digestive upset or allergic reactions are possible. Lactase is rated likely safe in pregnancy; protease and lipase should be used in pregnancy only if your doctor advises it.
For breastfeeding, lactase can be used; protease and lipase need medical advice first. Rare allergic reactions to protease powder and lactase powder have been reported in workers exposed to airborne dust.
We could not check safety data for amylase, L-glutamic acid, maltase, sucrase, ox bile, or Tolerase-G.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, we could not verify several others (amylase, L-glutamic acid, maltase, sucrase, ox bile, and Tolerase-G), so check with your doctor or pharmacist if you take any prescription medications.
The bottom line
Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
SIBOZyme is a multi-enzyme digestive aid that may help with lactose intolerance, though evidence for its other ingredients is not established in our data. Adults generally tolerate it well, but anyone with serious digestive conditions, pregnancy or breastfeeding plans, or a history of enzyme allergies should talk with their doctor or pharmacist first.
Check your medications against the interactions tool on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about SIBOZyme, straight from the product label.
| Brand | Priority One Nutritional Supplements |
|---|---|
| Barcode (UPC) | 815354020303 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 310783 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for SIBOZyme by Priority One Nutritional Supplements, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| L-Glutamic Acid | 220 mg | -- |
| Protease | 0 NP | -- |
| Lipase | 0 NP | -- |
| Lactase | 100 mg | -- |
| Maltase | 100 mg | -- |
| Pancreatin | 400 mg | -- |
| Sucrase | 100 mg | -- |
| Ox Bile | 300 mg | -- |
| Tolerase-G | 25 mg | -- |
Other ingredients: Rice Flour, Silicon Dioxide, Gelatin, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: If you are pregnant or breast feeding, consult your physician before using this product.
Keep out of reach of children.
For professional use only.
Suggested/Recommended/Usage/Directions
Recommendations: Take three (3) capsules two times daily before meals or as directed by your physician.
Storage
Keep container tightly closed, store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Contains no preservatives. Bisphenol-A (BPA) & Phthalate free
General Statements
Formulated by Dr. Mona Morstein
FDA Statement of Identity
A Dietary Supplement
Brand IP Statement(s)
Tolerase-G is a trademark of DSM.
Priority One Nutritional Supplements Inc. Since 1988
Seals/Symbols
GMP Certified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
SIBOZyme by Priority One Nutritional Supplements label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in SIBOZyme by Priority One Nutritional Supplements
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Glutamic Acid
Lactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsMaltase
Sucrase
Ox Bile
Tolerase-G
Other (inactive) ingredients: Rice Flour, Silicon Dioxide, Gelatin, Water, Purified. These complete the product’s ingredient list but are not active constituents.
SIBOZyme by Priority One Nutritional Supplements Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in SIBOZyme. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for SIBOZyme, from the product label.
Priority One Nutritional Supplements
See all Priority One Nutritional Supplements products- Name
- Priority One Nutritional Supplements, Inc.
- Web Address
- www.priorityonevitamins.com
SIBOZyme by Priority One Nutritional Supplements: Common Questions
Does SIBOZyme by Priority One Nutritional Supplements interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is lactase in this product safe during pregnancy?
Can I take this while breastfeeding?
What is lactase in this product used for?
Will this help with my digestion?
Are there any rare allergic risks with this product?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if SIBOZyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind SIBOZyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph →Sources & How We Checked
SIBOZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC