Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Super Digestive Enzymes Ingredients & Drug Interactions

by Herbadiet

Super Digestive Enzymes label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Digestive Enzymes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Super Digestive Enzymes is a dietary supplement by Herbadiet with 2 active ingredients. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Digestive Enzymes by Herbadiet

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Digestive Enzymes by Herbadiet — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Super Digestive Enzymes by Herbadiet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Super Digestive Enzymes contains 2 active ingredients: papaya fruit extract and pineapple fruit extract. Papaya contains papain, an enzyme that helps break down proteins during digestion.

Pineapple provides bromelain, another protein-digesting enzyme. The product has no inactive fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: ease gastrointestinal discomfort and support digestive health.
  • We looked for evidence on: Intestinal parasite infection, Bloating, Gas, Indigestion, Irritable bowel syndrome.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).

We hold insufficient evidence to rate papaya for any of the digestive or health conditions the research covers — aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes are all listed as having insufficient reliable evidence. The effectiveness data on file does not address digestive enzyme function or general digestive support, so we cannot tell you whether this product works for those purposes based on the information we have.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ripe papaya fruit eaten as food is generally well tolerated. Papaya leaf extract seems to be generally well tolerated too, though some people report nausea and vomiting.

Papain from raw or unripe papaya can trigger allergic reactions — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea — especially in people with latex allergies. Serious allergic reactions are rare but possible.

Unripe papaya, papaya latex, and papaya seeds should be avoided. Concentrated supplements and large amounts are less well studied than ripe fruit, so eating moderate amounts of ripe papaya is likely safer than relying on supplements.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood sugar medications (antidiabetes drugs), amiodarone (Cordarone) for heart rhythm, warfarin (Coumadin) or other blood thinners, or levothyroxine (Synthroid) for thyroid. These are the drug types where papaya fruit extract has documented Moderate interactions.

No interactions are documented in our data for pineapple fruit extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with digestion if the enzyme content is active and effective, but we don't have solid evidence to confirm that. The bigger concern is that papaya extract can interact with blood sugar medications, heart rhythm drugs, blood thinners, and thyroid replacement — and with 92 individual medications documented to interact with papaya.

Before you start, talk with your doctor or pharmacist about whether it's safe to combine with your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Digestive Enzymes, straight from the product label.

Brand Herbadiet
Barcode (UPC) 5113339193981
Net contents 60 V-Cap(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 244257
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Digestive Enzymes by Herbadiet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
5113339193981
IngredientAmount% DV
Papaya fruit extract250 mg--
Pineapple fruit extract250 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

If you are struggling with digestive issues such as bloating, gas, constipation, indigestion, or IBS we may have a natural solution for you.

Super Digestive Enzymes A Blend of Papain & Bromelain

Formulation

Herbadiet's Super Digestive Enzyme is a powerful supplement to ease and reduce gastrointestinal pains and discomforts. Don't let digestive problems hold you back. Take charge of your gut health today!

All Natural Gastrointestinal Support Enhances Absorption of Nutrients Improves Digestive Functions

100% Natural

Digestive Support Ayurvedic Proprietary Medicine

Vegan

Free of fillers, binders, artificial ingredients, dairy, soy, wheat, gluten, yeast

Suitable for vegetarians and vegans

Contains nothing other than listed ingredients

FDA Disclaimer Statement

These statement have not been evaluated by FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Do not use if seal under the cap is broken or missing.

Caution: If you are pregnant, breast feeding, or taking medications, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Storage

Store in a dry place.

General Statements

Batch No: ARK-C48

Suggested/Recommended/Usage/Directions

Directions for use: Take one capsule twice a day, or as directed by your physician.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Digestive Enzymes by Herbadiet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Digestive Enzymes label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Digestive Enzymes by Herbadiet

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papaya fruit extract

Interacts with
92 drugs
250 mg per serving Form: Papain

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya fruit extract monograph & interactions

Pineapple fruit extract

250 mg per serving Form: Bromelain
Interaction report

Super Digestive Enzymes by Herbadiet Drug Interactions

Want to check YOUR meds against Super Digestive Enzymes?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Papaya fruit extract 92

Individual Drug Interactions

The ingredients in Super Digestive Enzymes interact with 92 drugs. Click any drug to see the details.

1 of the 2 ingredients in Super Digestive Enzymes interact with drugs. Each result below shows which ingredient is responsible. Papaya fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Digestive Enzymes with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya fruit extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Digestive Enzymes, from the product label.

Herbadiet

See all Herbadiet products
Name
Arkure Health Care
Street Address
11, Sector - 14
City
Rohtak
State
Haryana
ZipCode
124001
Web Address
www.herbadiet.in
Pharmacist Counseling Corner

Super Digestive Enzymes by Herbadiet: Common Questions

Does Super Digestive Enzymes by Herbadiet interact with any medications?
Yes. Based on its ingredients, Super Digestive Enzymes has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Digestive Enzymes contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papaya fruit extract safe during pregnancy?
The data shows papaya is rated both likely safe and possibly unsafe during pregnancy — the safety picture is mixed. Because of this uncertainty, talk with your doctor or pharmacist before taking this product while pregnant. Large amounts are specifically cautioned against.
Can I take this if I'm breastfeeding?
Papaya fruit extract is rated likely safe during lactation. However, since we have no interaction data for pineapple fruit extract and no safety data on the full product as a supplement, ask your doctor or pharmacist to confirm it's okay for you.
What are the most common side effects?
Ripe papaya fruit eaten as food is well tolerated with minimal side effects. Papaya leaf extract has caused nausea and vomiting in clinical studies. Papain (from raw or unripe papaya) can trigger allergic symptoms like itchy eyes, sneezing, stomach cramps, and diarrhea, especially in people allergic to latex.
Why does this product say it has digestive enzymes if the evidence isn't proven?
Papaya and pineapple do contain protein-digesting enzymes (papain and bromelain), which is why they're used in digestive supplements. However, the evidence we hold doesn't rate how well these enzymes actually work for digestion when taken as a supplement — only for other conditions.
Should I avoid this product if I'm allergic to latex?
Yes, you should be cautious. Papain, a component of papaya, can trigger hypersensitivity reactions more commonly in people with latex allergies, including a serious condition called systemic contact dermatitis. Talk with your doctor or pharmacist before taking this.
Is unripe papaya safe in this supplement?
No — unripe (green) papaya, papaya latex, and papaya seeds should be avoided. The safety data advises against them. This product uses papaya fruit extract, so confirm with the manufacturer whether it's made from ripe fruit only.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Digestive Enzymes label
Go deeper

The Full Monographs Behind Super Digestive Enzymes’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Super Digestive Enzymes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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