Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Vari-Plex Ingredients & Drug Interactions

by Mountain Meadow Herbs

Vari-Plex label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vari-Plex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vari-Plex is a dietary supplement by Mountain Meadow Herbs with 3 active ingredients. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vari-Plex by Mountain Meadow Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Vari-Plex by Mountain Meadow Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vari-Plex by Mountain Meadow Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.25 mL) without saying how much of each component you get.

Vari-Plex is a liquid supplement with 3 active ingredients. The main active is bilberry, which appears twice in the formula — a concentrated plant extract rich in anthocyanidins, the pigments that give bilberries their deep purple color.

The product also contains bayberry, another plant-based ingredient. Both are combined in a base of glycerin, purified water, and grain alcohol.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Vein support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Hemorrhoids, Venous circulation, Vascular health.
  • The closest evidence on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Varicose veins.

The evidence for bilberry in this product is thin. For night vision — one of bilberry's most common marketing claims — the data shows it's possibly ineffective.

For other uses listed in our monograph, including age-related cognitive decline, macular degeneration, atherosclerosis, high cholesterol, and chronic venous insufficiency, there isn't enough reliable evidence to rate bilberry one way or the other. We hold no effectiveness data for bayberry.

The evidence, ingredient by ingredient Bilberry Bayberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry extracts are generally well tolerated, though the most common side effects are dark-colored stools, gas, and stomach discomfort — nothing serious, but worth expecting. In clinical trials, a small number of participants reported mild-to-moderate flatulence or temporary stomach upset.

You may also notice dark staining of your tongue, teeth, or stools. Bilberry in food amounts is considered likely safe in pregnancy and lactation, but concentrated supplement doses haven't been studied enough to know either way.

Bayberry is a different story. The safety data is too thin to recommend it, and because of concerns about stomach irritation, liver effects, and compounds in the bark, it's best avoided during pregnancy and while breastfeeding.

The combination of both ingredients in this product means you're getting less evidence about long-term safety than we'd like.

Side effects, ingredient by ingredient Bilberry Bayberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Vari-Plex, double-check any blood thinners or antiplatelet drugs you're on — bilberry may increase bleeding risk. Also flag diabetes medications in case of low blood sugar, any drugs processed through your liver's CYP2E1 enzyme, and erlotinib (Tarceva) if you're taking it for cancer.

We hold no interaction data for bayberry, so mention that ingredient to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes drugs, erlotinib, or any medication metabolized by liver enzymes, check with your pharmacist before starting this one — bilberry's interactions are real and worth reviewing. Bayberry adds extra caution because we know so little about its safety in supplement form.

Bilberry itself is generally well tolerated, but don't expect it to sharpen your night vision or improve cognitive decline.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vari-Plex, straight from the product label.

Brand Mountain Meadow Herbs
Barcode (UPC) 813086010678
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 327807
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Pregnant Women, Adult Female (18 - 50 Years), Lactating, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vari-Plex by Mountain Meadow Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.13 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
96
UPC/BARCODE
813086010678
IngredientAmount% DV
Proprietary Blend1.25 mL--
Bilberry0 NP--
Bilberry0 NP--
Bayberry0 NP--

Other ingredients: Glycerin, Water, Purified, Grain Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Vein Support

GF (Gluten free)

Vegan

For strong and healthy veins Normalize circulation Maintain vein strength Effective support for leg comfort

Formula

Women

FDA Statement of Identity

Herbal Dietary Supplement

General Statements

1 dropperful = approx. 1/8 tsp.

The MMH Three Leaf Promise: Our high-standards produce nothing less than pure, safe, and effective herbal products. You will always feel that we care - through our products, our service, and our understanding. We deliver on time.

Seals/Symbols

Made in Montana USA

Suggested/Recommended/Usage/Directions

Suggested use: Take 1/4 tsp. Take 1-3 times daily or as needed. If taking gentle birth, decrease dose to 1/8 tsp. Shake well.

Precautions

Caution: If you are pregnant, nursing, have a medical condition, or are taking a prescription, consult your health care provider before using this product.

Keep out of reach of children.

Storage

Store in a cool, dry place out of sunlight.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vari-Plex by Mountain Meadow Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vari-Plex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vari-Plex by Mountain Meadow Herbs

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.13 Teaspoon(s) Dosage formLiquid Servings per container96 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1.25 mL per serving

Other (inactive) ingredients: Glycerin, Water, Purified, Grain Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vari-Plex by Mountain Meadow Herbs Drug Interactions

Want to check YOUR meds against Vari-Plex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry 275

Individual Drug Interactions

The ingredients in Vari-Plex interact with 275 drugs. Click any drug to see the details.

1 of the 3 ingredients in Vari-Plex interact with drugs. Each result below shows which ingredient is responsible. Bilberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Vari-Plex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vari-Plex, from the product label.

Mountain Meadow Herbs

See all Mountain Meadow Herbs products
Name
Mountain Meadow Herbs, Inc.
Street Address
1019 Hard Rock Rd
City
Somers
State
MT
ZipCode
59932
Phone Number
888.528.8615
Web Address
www.mmherbs.com
Pharmacist Counseling Corner

Vari-Plex by Mountain Meadow Herbs: Common Questions

Does Vari-Plex by Mountain Meadow Herbs interact with any medications?
Yes. Based on its ingredients, Vari-Plex has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vari-Plex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this really help my eyesight?
The evidence doesn't support it. For night vision, bilberry is rated possibly ineffective. For age-related macular degeneration and other eye conditions, there isn't enough reliable data to say whether it helps or not.
What are the side effects I should watch for?
Bilberry is generally well tolerated, but expect dark stools, gas, and stomach discomfort as the most common effects. Your tongue, teeth, or stool may also turn dark — that's just the pigment from the bilberry and isn't harmful. A small number of people in trials reported temporary stomach upset or flatulence.
Is this safe to take while I'm pregnant?
Bilberry in food amounts is likely safe in pregnancy, but we don't have enough data on concentrated supplement doses to say either way — talk with your doctor or pharmacist for personalized advice. Bayberry, the other active ingredient, hasn't been studied enough in pregnancy, so it's best avoided.
Can I take this while breastfeeding?
Bilberry in food amounts is likely safe while breastfeeding, but again, concentrated supplement doses haven't been studied enough to know for sure. Bayberry is best avoided because of insufficient safety data. Check with your pharmacist about what's right for you.
What's actually in this bottle?
The active ingredients are bilberry (listed twice) and bayberry, suspended in glycerin, purified water, and grain alcohol. The alcohol and glycerin are there to preserve and stabilize the liquid extract.
Why is this a liquid instead of a pill?
Liquid extracts allow the active plant compounds to be absorbed more readily and make dosing flexible. The glycerin and grain alcohol help preserve the bilberry and bayberry extracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vari-Plex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vari-Plex label
Go deeper

The Full Monographs Behind Vari-Plex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Bayberry

Bayberry is a traditional herb used mainly as an astringent for diarrhea, sore throats, and minor skin or gum problems, but there is very little modern human research to confirm it works. It...

Read the full Bayberry monograph →
Sources

Sources & How We Checked

Vari-Plex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Bayberry 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

See these in context on the Bayberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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