Wild Lettuce Leaf 500 mg Ingredients & Drug Interactions
by NusaPure
What is this page for?
First and foremost: checking Wild Lettuce Leaf 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Wild Lettuce Leaf 500 mg is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for insomnia and trouble sleeping, anxiety and restlessness, pain relief.Based on those ingredients, 393 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Organic Wild Lettuce. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Wild Lettuce Leaf 500 mg by NusaPure
Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Lettuce Leaf 500 mg by NusaPure — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Wild Lettuce Leaf 500 mg by NusaPure
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: organic wild lettuce at 500 mg per capsule. The capsule also holds inactive ingredients — cellulose, microcrystalline cellulose powder, magnesium stearate, and silica — which are fillers and binders that help form and hold the capsule together.
Does it work?
Couldn't assess
We don't have effectiveness data on file for wild lettuce in our monograph, so the evidence for what it does isn't established in the facts we hold. If you're considering it for a specific reason, chat with your pharmacist or doctor about what the research shows for your use.
How safe is it?
Well-documented data
Wild lettuce comes with significant safety cautions. At high doses, it's been linked to sweating, rapid breathing, fast heart rate, dilated pupils, dizziness, ringing in the ears, vision changes, head pressure, drowsiness, agitation, slowed breathing, and in severe cases, coma or death.
The data is limited, especially for people. It's not safe in pregnancy — there isn't enough information to know it's okay.
You should also avoid it while breastfeeding, as reliable safety data don't exist for nursing. If you're pregnant, nursing, or thinking about either, talk with your doctor or pharmacist before using this product.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications against these two categories with your doctor or pharmacist: sedating drugs (CNS depressants) — including sleep aids, anti-anxiety medications, and narcotic painkillers — and anticholinergic drugs used for overactive bladder, Parkinson's disease, or certain other conditions. Both carry Moderate interaction warnings with wild lettuce.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Wild Lettuce Leaf is a single-ingredient supplement with a track record of limited safety data and serious risks at high doses. If you take sedating medications or anticholinergic drugs, you'll want to check your exact prescriptions before starting it.
Talk with your doctor or pharmacist about whether this is right for you and whether it might interact with anything you're currently taking.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Wild Lettuce Leaf 500 mg, straight from the product label.
| Brand | NusaPure |
|---|---|
| Barcode (UPC) | X00299RJKP |
| Net contents | 180 Veg Cap(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2021 |
| DSLD ID | 247133 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Wild Lettuce Leaf 500 mg by NusaPure, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Organic Wild Lettuce | 125 mg | -- |
Other ingredients: Cellulose, Microcrystalline Cellulose powder, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: For adults, take one (1) capsule daily, preferably with a meal.
Precautions
Warning: This product is not intended for pregnant or nursing mothers or children under the age of 18. If you are pregnant, nursing or taking any medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Warning: This product is not intended for pregnant or nursing mothers or children under the age of 18. Keep out of reach of children.
Do not eat freshness packet. Keep in bottle.
Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility
Assembled in USA Natural Supports normal sleep/wake cycles Supports a relaxed mood Max Strength
Allergen Information: Contains no artificial coloring, artificial flavors, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients.
Storage
Store in a cool, dry place after opening.
General Statements
Please recycle.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Seals/Symbols
Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility
Manufactured in a cGMP Inspected Facility
Formula
Wild lettuce leaf 500 mg equivalent per capsule
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Wild Lettuce Leaf 500 mg by NusaPure label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Wild Lettuce Leaf 500 mg by NusaPure
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Organic Wild Lettuce
Interacts with393 drugs
Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...
Organic Wild Lettuce monograph & interactionsOther (inactive) ingredients: Cellulose, Microcrystalline Cellulose powder, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Wild Lettuce Leaf 500 mg by NusaPure Drug Interactions
HelloPharmacist Interaction Report
Wild Lettuce Leaf 500 mg by NusaPure carries documented interactions with two drug categories.
The most serious concern is with CNS depressants (sedating medications) — wild lettuce may add to their calming effects and side effects at a Moderate severity level.
Read the full breakdown — every affected drug type, severity by severity
It also has a Moderate interaction with anticholinergic drugs (medications that block certain nerve signals). The monograph notes that wild lettuce may contain hyoscyamine, an anticholinergic compound, though apparently in very small amounts.
Case reports exist of people taking large doses experiencing anticholinergic side effects like constipation, dry mouth, and dizziness.
Altogether, these interactions span 393 individual medications. Before you take this supplement, run your exact medications through the search tool on this page to check whether any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Wild Lettuce Leaf 500 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Wild Lettuce Leaf 500 mg interact with 393 drugs. Click any drug to see the details.
1 of the 1 ingredient in Wild Lettuce Leaf 500 mg interact with drugs. Each result below shows which ingredient is responsible. Organic Wild Lettuce
ZuranoloneZurzuvae
How Zuranolone interacts with Wild Lettuce Leaf 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic Wild LettuceCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Organic Wild Lettuce + Zuranolone interactionAcetaminophen, Dextromethorphan, DoxylamineNyQuil
How Acetaminophen, Dextromethorphan, Doxylamine interacts with Wild Lettuce Leaf 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic Wild LettuceCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Organic Wild Lettuce + Acetaminophen, Dextromethorphan, Doxylamine interactionDroperidolInapsine
How Droperidol interacts with Wild Lettuce Leaf 500 mg — through 1 ingredient. Tap an ingredient for the detail:
Organic Wild LettuceCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Read the full Organic Wild Lettuce + Droperidol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Wild Lettuce Leaf 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Organic Wild Lettuce
Anticholinergic Drugs
Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.
Cns Depressants
Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.
Brand information
Manufacturer and brand details for Wild Lettuce Leaf 500 mg, from the product label.
NusaPure
See all NusaPure products- Name
- Gmax Central LLC
- Street Address
- 4700 Millenia Boulevard, Suite 175 PMB 92909
- City
- Orlando
- State
- FL
- ZipCode
- 32839
Wild Lettuce Leaf 500 mg by NusaPure: Common Questions
Does Wild Lettuce Leaf 500 mg by NusaPure interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Wild Lettuce Leaf if I'm pregnant?
Can I take this while breastfeeding?
What are the side effects of wild lettuce?
Does wild lettuce contain hyoscyamine?
Should I be concerned about the interactions listed?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Wild Lettuce Leaf 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Wild Lettuce Leaf 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Wild Lettuce Leaf 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Wild Lettuce 5 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Besharat S, Besharat M, Jabbari A. Wild lettuce (Lactuca virosa) toxicity. BMJ Case Rep. 2009;2009. pii: bcr06.2008.0134.
- Mullins ME, Horowitz BZ. The case of the salad shooters: intravenous injection of wild lettuce extract. Vet Hum Toxicol. 1998;40(5):290-1.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC