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Dietary supplement

Wild Yam Root 450 mg Ingredients & Drug Interactions

by Vitamin World

Wild Yam Root 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Wild Yam Root 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Wild Yam Root 450 mg is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, menstrual cramps, hormone balance (popular belief).Based on those ingredients, 41 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Wild Yam. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Wild Yam Root 450 mg by Vitamin World

Ask about any prescription or over-the-counter medication and we check it for interactions with Wild Yam Root 450 mg by Vitamin World — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Wild Yam Root 450 mg by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: wild yam root at 450 mg per capsule. Wild yam has been used traditionally in herbal medicine, though its exact mechanisms in the body aren't fully understood.

The capsule itself is made from gelatin and vegetable cellulose, which are the inactive ingredients that hold the supplement together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Wild Yam product and its label doesn't state a use — see Wild Yam's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for wild yam is limited. For menopausal symptoms, the data suggests it's possibly ineffective.

For gallbladder disease, sexual dysfunction, irregular periods (dysmenorrhea), and infertility, there isn't enough reliable evidence in our data to rate whether it works. If you're considering this supplement for any of those uses, talk it over with your doctor or pharmacist about what the current research actually supports.

The evidence, ingredient by ingredient Wild Yam

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Wild yam is generally well tolerated when taken by mouth in the short term for healthy adults, though long-term safety hasn't been well studied. The most common side effects reported are fever, headache, upset stomach, and vomiting — especially at higher doses.

Anaphylaxis (a severe allergic reaction) is rare but has been reported. During pregnancy, there isn't enough safety data; the facts advise against use.

The same holds for breastfeeding — avoid it unless you've talked with your doctor or pharmacist, since we don't have enough information about safety.

Side effects, ingredient by ingredient Wild Yam

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Wild Yam.
  • The most serious interaction on file is rated Moderate.
  • For scale: 41 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any estrogen-based medications — including birth control pills, hormone replacement therapy, or estrogen patches. Wild yam may theoretically increase or decrease how estrogen works.

No other medication interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Wild Yam Root might be worth considering if you're interested in a traditional herbal supplement, but the evidence for most uses is weak or absent. The main caution is if you take any estrogen-based medication — you'll need to check with your doctor or pharmacist first.

And because long-term safety isn't well studied, this is best used short-term and under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Wild Yam Root 450 mg, straight from the product label.

Brand Vitamin World
Barcode (UPC) 799443568247
Net contents 100 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 67152
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Wild Yam Root 450 mg by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
799443568247
IngredientAmount% DV
Wild Yam900 mg--

Other ingredients: Gelatin, Vegetable Cellulose, Contains <2% of

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take two (2) capsules daily, preferably with a meal.

Brand IP Statement(s)

At Vitamin World we ensure the quality of all of our premium nutritional products, every step of the way. Strict quality analysis at world-class facilities guarantees that all Vitamin World products are at the highest standard of potency and purity.

2016 Vitamin World, Inc.

Nutrition from the source

Formulation

No Artificial Color, Flavor or Sweetener, no Preservatives, no Sugar, no Starch, no Milk, no Lactose, no Soy, no Gluten, no Wheat, no Yeast, no Fish. Sodium free.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

General Statements

To reorder prod. #56824 www.vitaminworld.com 1-800-228-4533

General

PROD. #56824 B67417 01A

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Wild Yam has been known for centuries as a popular herb for women. Wild Yam contains natural compounds, and is used by women around the world, especially during midlife years.

Women’s health

Seals/Symbols

Quality Assured

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Wild Yam Root 450 mg by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Wild Yam Root 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Wild Yam Root 450 mg by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Wild Yam

Interacts with
41 drugs
900 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Cellulose, Contains <2% of. These complete the product’s ingredient list but are not active constituents.

Interaction report

Wild Yam Root 450 mg by Vitamin World Drug Interactions

Want to check YOUR meds against Wild Yam Root 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
41Drugs
41 Moderate

Ingredients driving the most interactions

Wild Yam 41

Individual Drug Interactions

The ingredients in Wild Yam Root 450 mg interact with 41 drugs. Click any drug to see the details.

1 of the 1 ingredient in Wild Yam Root 450 mg interact with drugs. Each result below shows which ingredient is responsible. Wild Yam

Each ingredient & the kinds of drugs it affects

For each ingredient in Wild Yam Root 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Wild Yam1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Wild Yam Root 450 mg, from the product label.

Vitamin World

See all Vitamin World products
Name
Vitamin World, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Wild Yam Root 450 mg by Vitamin World: Common Questions

Does Wild Yam Root 450 mg by Vitamin World interact with any medications?
Yes. Based on its ingredients, Wild Yam Root 450 mg has a known interaction with 41 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Wild Yam Root 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take wild yam if I'm on birth control or hormone replacement therapy?
Not without checking first. Wild yam has estrogenic and anti-estrogenic effects that could theoretically interfere with how your hormone therapy works — either boosting or reducing its effects. Talk to your doctor or pharmacist about your specific medication before taking this.
Does wild yam actually help with hot flashes or other menopausal symptoms?
The evidence suggests it's not effective for menopausal symptoms. If that's why you're considering it, a conversation with your doctor about what options do have solid evidence behind them would be worthwhile.
What are the most common side effects?
Fever, headache, upset stomach, and vomiting — especially if you take higher doses. Most people tolerate it well, but these are the ones to watch for.
Is it safe to take long-term?
Long-term safety hasn't been well studied, so the data we have supports short-term use in healthy adults. If you're thinking about taking it regularly for weeks or months, check with your doctor or pharmacist first.
Can I take this while pregnant or breastfeeding?
The safety data advises against it in both cases — there just isn't enough information to know either way. Talk with your doctor or pharmacist about whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Wild Yam Root 450 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Wild Yam Root 450 mg label
Go deeper

The Full Monographs Behind Wild Yam Root 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph →
Sources

Sources & How We Checked

Wild Yam Root 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Wild Yam 7 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  3. Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
  4. Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. PubMed
  5. Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
  6. Zeng M, Zhang L, Li M, et al. Estrogenic effects of the extracts from the Chinese Yam (Dioscorea opposite Thunb.) and its effective compounds in vitro and in vivo. Molecules. 2018 Jan 23;23(2). Pii: E11. PubMed
  7. Lu J, Wong RN, Zhang L, et al. Comparative analysis of proteins with stimulating activity on ovarian estradiol biosynthesis from four different Dioscorea species in vitro using both phenotypic and target-based approaches: implication for treating menopaus

See these in context on the Wild Yam monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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