No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Zygest Lactase Enzyme Ingredients & Drug Interactions

by Vitamin World

Softgel Capsule Category: Non-nutrient/non-botanical
No known interaction
The interaction bottom line No known interaction

Zygest Lactase Enzyme is a dietary supplement by Vitamin World with 1 active ingredient. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

HelloPharmacist Scorecard of Zygest Lactase Enzyme by Vitamin World

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lactase enzyme. Lactase is the natural enzyme your small intestine makes to break down lactose, the sugar found in milk and dairy products.

If your body doesn't make enough of its own lactase, taking this enzyme supplement can help you digest dairy without the bloating, gas, or cramping that comes with lactose intolerance. The other ingredients are inactive — soybean oil, gelatin, sorbitol, vegetable glycerin, soy lecithin, yellow beeswax, and titanium dioxide — they're there to form and color the softgel capsule.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: helps break down lactose in milk and dairy.
  • We looked for evidence on: Lactose intolerance, Lactose malabsorption, Dairy digestion, Lactose sensitivity.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).

Lactase enzyme is effective for lactose intolerance. The evidence we hold shows it works for helping you digest lactose when you eat or drink dairy products.

For other uses — colic in infants and prematurity — we don't have enough reliable evidence yet to rate whether it helps. If you're taking this for lactose intolerance, the data supports its use.

The evidence, ingredient by ingredient Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactase is generally well tolerated when you take it as directed. One reported case linked occupational exposure to powdered lactase (inhaled in the workplace) to allergic reactions including contact dermatitis and a form of nasal and eye allergy.

This was in a worker breathing in lactase dust repeatedly — not the same as taking a softgel capsule by mouth. If you have a known allergy to lactase itself, avoid this product.

The safety data for pregnancy and breastfeeding shows lactase is likely safe, but because data is limited, ask your doctor or pharmacist first before using it regularly while pregnant or nursing.

Side effects, ingredient by ingredient Lactase

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for lactase in our data. It works in the gut and doesn't appear to affect how medications are processed in the body.

You don't need to hold off for drug interactions — but as always, mention this supplement to your pharmacist if you're starting anything new.

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. No medication interactions are currently documented, and safety information is well characterized.

If you have lactose intolerance and want to enjoy dairy without discomfort, this product has solid evidence behind it. Anyone with a known lactase allergy should skip it.

If you're pregnant, nursing, or have questions about whether it's right for you, check with your doctor or pharmacist — the data is limited enough that personalized advice is worth the conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Zygest Lactase Enzyme, straight from the product label.

Brand Vitamin World
Barcode (UPC) 074312749308
Net contents 60 Easy to Swallow Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 943
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Zygest Lactase Enzyme by Vitamin World, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
20
UPC/BARCODE
074312749308
IngredientAmount% DV
Zygest Lactase enzyme375 mg--

Other ingredients: Soybean Oil, Gelatin, Sorbitol, Vegetable Glycerin, Soy Lecithin, yellow Beeswax, Titanium Dioxide color

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

© 2009 Vitamin World, Inc.

Many factors can contribute to poor digestion, including lactose intolerance. Lactase is a digestive enzyme that helps break down the sugar in milk and dairy products.* Milk and dairy products are important sources of Calcium. Supplementing with Zygest(R) Lactase Enzyme Milk and Dairy Digestant can make milk more readily digestible to your system.*

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

No Artificial Flavor, No Sugar, No Milk, No Lactose, No Yeast, No Fish. Sodium Free.

Precautions

Contains wheat and soy ingredients.

WARNING: If you are pregnant, nursing or taking any medications, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store in a cool, dry place. Do not use if seal under cap is broken or missing.

General

PROD. #4930 B4930 06D

General Statements

Milk & Dairy Digestant

Supports Digestive Health*

Vitamin World products are subject to critically stringent quality assurance analysis. Our state-of-the-art laboratory, manufacturing and packaging facilities insure the highest quality nutritional supplements money can buy. Your health & safety are our first priority!

Get healthy.

Seals/Symbols

QUALITY ASSURED

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) to three (3) softgels just before eating a meal, food or drink that contains lactose. Take one (1) softgel with medication or vitamins that contain lactose. These softgels should be swallowed, and should not be added directly to milk or other dairy products.

See for yourself

Zygest Lactase Enzyme by Vitamin World label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Zygest Lactase Enzyme by Vitamin World

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container20 Amounts shown are per serving.

Zygest Lactase enzyme

No known
interactions
375 mg per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Zygest Lactase enzyme monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Sorbitol, Vegetable Glycerin, Soy Lecithin, Yellow Beeswax, Titanium Dioxide color. These complete the product’s ingredient list but are not active constituents.

Interaction report

Zygest Lactase Enzyme by Vitamin World Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Zygest Lactase Enzyme. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Zygest Lactase Enzyme, from the product label.

Vitamin World

See all Vitamin World products
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Zygest Lactase Enzyme by Vitamin World: Common Questions

Does Zygest Lactase Enzyme by Vitamin World interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Zygest Lactase Enzyme. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Zygest Lactase Enzyme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lactase and what does it do?
Lactase is an enzyme your small intestine naturally makes to break down lactose, the sugar in milk and dairy. If you don't make enough of your own lactase, taking it as a supplement helps you digest dairy without bloating, gas, or cramping.
Is lactase effective for lactose intolerance?
Yes. The evidence shows lactase enzyme is effective for lactose intolerance. It works by helping your body digest the lactose in dairy products.
Can I take this while pregnant or breastfeeding?
The data shows lactase is likely safe in pregnancy and while nursing. Because the data is limited, talk with your doctor or pharmacist first before using it regularly during these times — they can give you personalized advice based on your situation.
Are there any side effects I should know about?
Lactase is generally well tolerated. One reported case linked workplace exposure to lactase dust (not a softgel taken by mouth) to allergic reactions. If you have a known allergy to lactase, avoid this product.
What are the inactive ingredients?
The capsule contains soybean oil, gelatin, sorbitol, vegetable glycerin, soy lecithin, yellow beeswax, and titanium dioxide. These ingredients help form and color the softgel — they're not active.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Zygest Lactase Enzyme is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Zygest Lactase Enzyme label
Go deeper

The Full Monographs Behind Zygest Lactase Enzyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Zygest Lactase Enzyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 1 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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