Butabarbital

Butabarbital is used on a short-term basis to treat insomnia (difficulty falling asleep or staying asleep). It is also used to relieve anxiety, including anxiety before surgery. Butabarbital is in a class of medications called barbiturates. It works by slowing activity in the brain.

Butabarbital comes as a tablet and a solution (liquid) to take by mouth. When butabarbital is used to treat insomnia, it is usually taken at bedtime as needed for sleep. When butabarbital is used to relieve anxiety before surgery, it is usually taken 60 to 90 minutes before surgery. When butabarbital is used to relieve anxiety, it is usually taken three to four times a day. If you are taking butabarbital on a regular schedule, take it at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take butabarbital exactly as directed.

Your sleep problems should improve within 7 to 10 days after you start taking butabarbital. Call your doctor if your sleep problems do not improve during this time, if they get worse at any time during your treatment, or if you notice any changes in your thoughts or behavior.

Butabarbital should normally be taken for short periods of time. If you take butabarbital for 2 weeks or longer, butabarbital may not help you sleep as well or control your anxiety as it did when you first began to take the medication. If you take butabarbital for a long time, you also may develop dependence ('addiction,' a need to continue taking the medication) on butabarbital. Talk to your doctor about the risks of taking butabarbital for 2 weeks or longer. Do not take a larger dose of butabarbital, take it more often, or take it for a longer time than prescribed by your doctor.

Do not stop taking butabarbital without talking to your doctor. Your doctor will probably decrease your dose gradually. If you suddenly stop taking butabarbital, you may develop anxiety, muscle twitching, uncontrollable shaking of your hands or fingers, weakness, dizziness, changes in vision, nausea, vomiting, or difficulty falling asleep or staying asleep, or you may experience more severe withdrawal symptoms such as seizures or extreme confusion.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking butabarbital,

• tell your doctor and pharmacist if you are allergic to butabarbital; other barbiturates such as amobarbital (Amytal, in Tuinal), pentobarbital, phenobarbital, or secobarbital (Seconal); tartrazine (a yellow dye found in some foods and medications); aspirin; or any other medications. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antihistamines; doxycycline (Doryx, Vibramycin; Vibra-tabs); griseofulvin (Fulvicin-U/F, Grifulvin V, Gris-PEG); hormone replacement therapy; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for depression, pain, colds or allergies; muscle relaxants; certain medications for seizures such as phenytoin (Dilantin) and valproic acid (Depakene); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone; sedatives; sleeping pills; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have or have ever had porphyria (condition in which certain natural substances build up in the body and may cause stomach pain, changes in thinking and behavior, and other symptoms). Your doctor will probably tell you not to take butabarbital.

• tell your doctor if you drink or have ever drunk large amounts of alcohol, use or have ever used street drugs, or have overused prescription medications. Also tell your doctor if you have ever thought about killing yourself or tried to do so and if you have or have ever had asthma or any condition that causes shortness of breath or difficulty breathing; depression; seizures; or kidney or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking butabarbital, call your doctor immediately. Butabarbital may harm the fetus.

• you should know that butabarbital may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, injections, implants, or intrauterine devices). Talk to your doctor about methods of birth control that will work for you during your treatment with butabarbital. Tell your doctor if you have a missed period or think you may be pregnant while you are taking butabarbital.

• talk to your doctor about the risks and benefits of taking this medication if you are 65 years of age or older. Older adults should not usually take butabarbital because it is not as safe or effective as other medication(s) that can be used to treat the same condition.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking butabarbital.

• you should know that this medication may make you drowsy during the daytime, may decrease your mental alertness, and may increase the risk that you could fall. Take extra care to be sure you do not fall, especially if you get out of bed in the middle of the night. Do not drive a car or operate machinery until you know how this medication affects you.

• do not drink alcohol during your treatment with butabarbital. Alcohol can make the side effects of butabarbital worse.

• you should know that some people who took medications for sleep got out of bed and drove their cars, prepared and ate food, had sex, made phone calls, or were involved in other activities while partially asleep. After they woke up, these people were usually unable to remember what they had done. Call your doctor right away if you find out that you have been driving or doing anything else while you were sleeping.

Unless your doctor tells you otherwise, continue your normal diet.

If you are taking butabarbital on a regular basis, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Butabarbital may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness

  • difficulty falling asleep or staying asleep

  • nightmares

  • headache

  • dizziness

  • depression

  • nervousness

  • agitation

  • excitement

  • confusion

  • restlessness

  • nausea

  • vomiting

  • constipation

• Some side effects can be serious. If you experience any of the following symptoms, or those listed in the SPECIAL PRECAUTIONS sections, call your doctor immediately:

  • hallucinating (seeing things or hearing voices that do not exist)

  • slow, shallow breathing

  • slow heartbeat

  • fainting

  • hives

  • rash

  • itching

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • difficulty breathing or swallowing

  • hoarseness

• Butabarbital may cause other side effects. Tell your doctor if you have any unusual problems while you are taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• unsteadiness

• slurred speech

• uncontrollable eye movements

• confusion

• poor judgment

• irritability

• difficulty falling asleep or staying asleep

• fast, slowed or shallow breathing

• narrowed pupils (black circles in the middle of the eye)

• decreased urination

• fast heartbeat

• low body temperature

• coma (loss of consciousness for a periol of time)

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to butabarbital.

Do not let anyone else take your medication. Butabarbital is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

• secbutobarabitone sodium

Drug	Interaction
Dolasetron	Dolasetron The risk or severity of adverse effects can be increased when Butabarbital is combined with Dolasetron.
Aminophylline	Aminophylline The therapeutic efficacy of Butabarbital can be decreased when used in combination with Aminophylline.
Bisacodyl	Bisacodyl The therapeutic efficacy of Bisacodyl can be decreased when used in combination with Butabarbital.
Cilostazol	Cilostazol Butabarbital may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Diphenoxylate	Diphenoxylate The risk or severity of adverse effects can be increased when Butabarbital is combined with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Butabarbital may decrease the excretion rate of Conjugated estrogens which could result in a higher serum level.
Fenofibrate	Fenofibrate Butabarbital may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine	Guanfacine The risk or severity of adverse effects can be increased when Butabarbital is combined with Guanfacine.
Magnesium Hydroxide	Magnesium Hydroxide Butabarbital may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Magnesium Oxide	Magnesium Oxide The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Butabarbital.
Mycophenolate	Mycophenolate Butabarbital may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan	Naratriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Naratriptan.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Paregoric	Paregoric The risk or severity of adverse effects can be increased when Butabarbital is combined with Morphine.
Penbutolol	Penbutolol Butabarbital may increase the hypotensive activities of Acebutolol.
Pentazocine	Pentazocine The risk or severity of adverse effects can be increased when Butabarbital is combined with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Butabarbital.
Potassium	Potassium Potassium may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Butabarbital may decrease the excretion rate of Prednisone which could result in a higher serum level.
Psyllium	Psyllium The therapeutic efficacy of Plantago seed can be decreased when used in combination with Butabarbital.
Ranitidine	Ranitidine Butabarbital may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine	Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Butabarbital.
Rizatriptan	Rizatriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Rizatriptan.
Sumatriptan	Sumatriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Sumatriptan.
Tacrolimus	Tacrolimus Tacrolimus may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Butabarbital is combined with Tizanidine.
Zolmitriptan	Zolmitriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Zolmitriptan.
Ampicillin Injection	Ampicillin Injection Butabarbital may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection The serum concentration of Doxycycline can be decreased when it is combined with Butabarbital.
Fluconazole Injection	Fluconazole Injection Fluconazole may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Hydromorphone.
Levofloxacin Injection	Levofloxacin Injection Butabarbital may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection	Meperidine Injection Butabarbital may increase the hypotensive and central nervous system depressant (CNS depressant) activities of Meperidine.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of sedation can be increased when Metoclopramide is combined with Butabarbital.
Morphine Injection	Morphine Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Morphine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Butabarbital may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Butabarbital.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cyclosporine	Cyclosporine The metabolism of Butabarbital can be increased when combined with Cyclosporine.
Ondansetron	Ondansetron The risk or severity of adverse effects can be increased when Butabarbital is combined with Ondansetron.
Granisetron	Granisetron The risk or severity of adverse effects can be increased when Butabarbital is combined with Granisetron.
Torsemide	Torsemide Torasemide may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine	Olanzapine The risk or severity of adverse effects can be increased when Butabarbital is combined with Olanzapine.
Alosetron	Alosetron The risk or severity of adverse effects can be increased when Butabarbital is combined with Alosetron.
Entacapone	Entacapone The risk or severity of adverse effects can be increased when Butabarbital is combined with Entacapone.
Eprosartan	Eprosartan Butabarbital may increase the hypotensive activities of Eprosartan.
Meloxicam	Meloxicam Meloxicam may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Oxcarbazepine	Oxcarbazepine The risk or severity of adverse effects can be increased when Butabarbital is combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Telmisartan	Telmisartan Butabarbital may increase the hypotensive activities of Telmisartan.
Temozolomide	Temozolomide Butabarbital may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon	Zaleplon The risk or severity of adverse effects can be increased when Butabarbital is combined with Zaleplon.
Desloratadine	Desloratadine The risk or severity of adverse effects can be increased when Butabarbital is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Butabarbital is combined with Linezolid.
Rivastigmine	Rivastigmine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Rivastigmine.
Trimipramine	Trimipramine The risk or severity of adverse effects can be increased when Butabarbital is combined with Trimipramine.
Glycopyrrolate	Glycopyrrolate Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Perindopril	Perindopril Perindopril may increase the hypotensive activities of Butabarbital.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Eplerenone	Eplerenone Eplerenone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of adverse effects can be increased when Butabarbital is combined with Escitalopram.
Olmesartan	Olmesartan Butabarbital may increase the hypotensive activities of Olmesartan.
Zonisamide	Zonisamide The risk or severity of adverse effects can be increased when Butabarbital is combined with Zonisamide.
Aripiprazole	Aripiprazole The risk or severity of adverse effects can be increased when Butabarbital is combined with Aripiprazole.
Atomoxetine	Atomoxetine The risk or severity of adverse effects can be increased when Butabarbital is combined with Atomoxetine.
Dexmethylphenidate	Dexmethylphenidate The risk or severity of adverse effects can be increased when Butabarbital is combined with Dexmethylphenidate.
Atazanavir	Atazanavir Atazanavir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Almotriptan	Almotriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Almotriptan.
Eletriptan	Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Butabarbital.
Mefloquine	Mefloquine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Mefloquine.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The therapeutic efficacy of Polyethylene glycol can be decreased when used in combination with Butabarbital.
Emtricitabine	Emtricitabine Butabarbital may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine	Memantine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Memantine.
Tegaserod	Tegaserod The therapeutic efficacy of Tegaserod can be decreased when used in combination with Butabarbital.
Tadalafil	Tadalafil Butabarbital may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan	Frovatriptan The risk or severity of adverse effects can be increased when Butabarbital is combined with Frovatriptan.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Apomorphine.
Protriptyline	Protriptyline The risk or severity of adverse effects can be increased when Butabarbital is combined with Protriptyline.
Duloxetine	Duloxetine The risk or severity of adverse effects can be increased when Butabarbital is combined with Duloxetine.
Tinidazole	Tinidazole Butabarbital may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium	Trospium Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cefditoren	Cefditoren Butabarbital may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Eszopiclone	Eszopiclone The risk or severity of CNS depression can be increased when Butabarbital is combined with Eszopiclone.
Ganciclovir	Ganciclovir Butabarbital may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin	Ribavirin Butabarbital may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin	Solifenacin Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir	Valganciclovir Butabarbital may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The serum concentration of Voriconazole can be decreased when it is combined with Butabarbital.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Butabarbital.
Sodium Oxybate	Sodium Oxybate Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Isocarboxazid	Isocarboxazid The risk or severity of adverse effects can be increased when Butabarbital is combined with Isocarboxazid.
Ramelteon	Ramelteon The risk or severity of adverse effects can be increased when Butabarbital is combined with Ramelteon.
Darifenacin	Darifenacin Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl	Fentanyl The risk or severity of adverse effects can be increased when Butabarbital is combined with Fentanyl.
Pregabalin	Pregabalin The therapeutic efficacy of Butabarbital can be increased when used in combination with Pregabalin.
Felbamate	Felbamate The serum concentration of Felbamate can be increased when it is combined with Butabarbital.
Ranolazine	Ranolazine Butabarbital may decrease the excretion rate of Ranolazine which could result in a higher serum level.
Rasagiline	Rasagiline The risk or severity of adverse effects can be increased when Butabarbital is combined with Rasagiline.
Sitagliptin	Sitagliptin Butabarbital may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline	Varenicline Butabarbital may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol	Albuterol Butabarbital may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone	Paliperidone The risk or severity of adverse effects can be increased when Butabarbital is combined with Paliperidone.
Clofarabine Injection	Clofarabine Injection Butabarbital may increase the hypotensive activities of Clofarabine.
Lubiprostone	Lubiprostone Butabarbital may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Aliskiren	Aliskiren Butabarbital may increase the hypotensive activities of Aliskiren.
Pemetrexed Injection	Pemetrexed Injection Butabarbital may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate	Dimenhydrinate The risk or severity of adverse effects can be increased when Butabarbital is combined with Dimenhydrinate.
Nabilone	Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Sorafenib	Sorafenib Butabarbital may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Dronabinol	Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Levocetirizine	Levocetirizine The risk or severity of adverse effects can be increased when Butabarbital is combined with Levocetirizine.
Pegaptanib Injection	Pegaptanib Injection Butabarbital may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection	Azacitidine Injection Butabarbital may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The therapeutic efficacy of Castor oil can be decreased when used in combination with Butabarbital.
Lenalidomide	Lenalidomide Butabarbital may decrease the excretion rate of Lenalidomide which could result in a higher serum level.
Budesonide	Budesonide Butabarbital may decrease the excretion rate of Budesonide which could result in a higher serum level.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Butabarbital can be decreased when combined with Chloramphenicol.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Betaine	Betaine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Glycine betaine.
OnabotulinumtoxinA Injection	OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Botulinum toxin type A.
RimabotulinumtoxinB Injection	RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Botulinum Toxin Type B.
Doripenem Injection	Doripenem Injection Butabarbital may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Butabarbital may increase the hypotensive activities of Arsenic trioxide.
Desvenlafaxine	Desvenlafaxine The risk or severity of adverse effects can be increased when Butabarbital is combined with Desvenlafaxine.
Cevimeline	Cevimeline Cevimeline may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Nebivolol	Nebivolol Butabarbital may increase the hypotensive activities of Nebivolol.
Tretinoin	Tretinoin Butabarbital may increase the hypotensive activities of Tretinoin.
Certolizumab Injection	Certolizumab Injection Butabarbital may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Methylnaltrexone Injection	Methylnaltrexone Injection Butabarbital may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide	Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Butabarbital.
Midazolam	Midazolam The risk or severity of adverse effects can be increased when Butabarbital is combined with Midazolam.
Naltrexone Injection	Naltrexone Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Butabarbital may decrease the excretion rate of Dexrazoxane which could result in a higher serum level.
Milnacipran	Milnacipran The risk or severity of adverse effects can be increased when Butabarbital is combined with Milnacipran.
Plerixafor Injection	Plerixafor Injection Butabarbital may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Sodium Phosphate	Sodium Phosphate The therapeutic efficacy of Sodium phosphate, monobasic can be decreased when used in combination with Butabarbital.
Fesoterodine	Fesoterodine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Betaxolol	Betaxolol Butabarbital may increase the hypotensive activities of Betaxolol.
Iloperidone	Iloperidone The risk or severity of adverse effects can be increased when Butabarbital is combined with Iloperidone.
Prasugrel	Prasugrel Butabarbital may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide	Lacosamide The risk or severity of adverse effects can be increased when Butabarbital is combined with Lacosamide.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
AbobotulinumtoxinA Injection	AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Botulinum toxin type A.
Pralatrexate Injection	Pralatrexate Injection Butabarbital may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection	Palonosetron Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Palonosetron.
Saxagliptin	Saxagliptin Butabarbital may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection	Telavancin Injection Butabarbital may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol	Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Topotecan	Topotecan Butabarbital may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine	Asenapine The risk or severity of adverse effects can be increased when Butabarbital is combined with Asenapine.
Vigabatrin	Vigabatrin The risk or severity of adverse effects can be increased when Butabarbital is combined with Vigabatrin.
Ulipristal	Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Butabarbital.
Oxymorphone	Oxymorphone The risk or severity of adverse effects can be increased when Butabarbital is combined with Oxymorphone.
Dalfampridine	Dalfampridine Butabarbital may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection	IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Botulinum toxin type A.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of adverse effects can be increased when Butabarbital is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Acetaminophen can be increased when combined with Butabarbital.
Vilazodone	Vilazodone The risk or severity of adverse effects can be increased when Butabarbital is combined with Vilazodone.
Ipilimumab Injection	Ipilimumab Injection Butabarbital may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may increase the hypotensive activities of Butabarbital.
Terbutaline Injection	Terbutaline Injection The therapeutic efficacy of Butabarbital can be decreased when used in combination with Terbutaline.
Azilsartan	Azilsartan Butabarbital may increase the hypotensive activities of Azilsartan medoxomil.
Roflumilast	Roflumilast Butabarbital may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban	Rivaroxaban Butabarbital may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib	Ruxolitinib Butabarbital may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam	Clobazam The risk or severity of adverse effects can be increased when Butabarbital is combined with Clobazam.
Deferiprone	Deferiprone Butabarbital may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline	Cabergoline The risk or severity of adverse effects can be increased when Butabarbital is combined with Cabergoline.
Naloxone Injection	Naloxone Injection Butabarbital may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection	Fondaparinux Injection Butabarbital may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine	Ezogabine The risk or severity of adverse effects can be increased when Butabarbital is combined with Tiagabine.
Iloprost	Iloprost Butabarbital may increase the hypotensive activities of Iloprost.
Enzalutamide	Enzalutamide Butabarbital may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron	Mirabegron Butabarbital may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Linaclotide	Linaclotide The therapeutic efficacy of Linaclotide can be decreased when used in combination with Butabarbital.
Teduglutide Injection	Teduglutide Injection Butabarbital may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin	Alogliptin Butabarbital may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide	Pomalidomide The risk or severity of adverse effects can be increased when Butabarbital is combined with Pomalidomide.
Canagliflozin	Canagliflozin The serum concentration of Canagliflozin can be decreased when it is combined with Butabarbital.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib	Trametinib Butabarbital may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran	Levomilnacipran The risk or severity of adverse effects can be increased when Butabarbital is combined with Levomilnacipran.
Ertapenem Injection	Ertapenem Injection Butabarbital may decrease the excretion rate of Ertapenem which could result in a higher serum level.
Vortioxetine	Vortioxetine The risk or severity of adverse effects can be increased when Butabarbital is combined with Vortioxetine.
Perampanel	Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Ketorolac Injection	Ketorolac Injection Ketorolac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Obinutuzumab Injection	Obinutuzumab Injection Butabarbital may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir	Sofosbuvir Butabarbital may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin	Dapagliflozin Dapagliflozin may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast	Apremilast Butabarbital may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa	Droxidopa Butabarbital may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Eslicarbazepine	Eslicarbazepine The risk or severity of adverse effects can be increased when Butabarbital is combined with Eslicarbazepine.
Testosterone Injection	Testosterone Injection Butabarbital may decrease the excretion rate of Testosterone which could result in a higher serum level.
Empagliflozin	Empagliflozin Butabarbital may increase the hypotensive activities of Empagliflozin.
Hydrocodone	Hydrocodone Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Suvorexant	Suvorexant Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban	Edoxaban Butabarbital may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine	Methamphetamine The risk or severity of adverse effects can be increased when Butabarbital is combined with Metamfetamine.
Tasimelteon	Tasimelteon The risk or severity of adverse effects can be increased when Butabarbital is combined with Tasimelteon.
Riociguat	Riociguat Butabarbital may increase the hypotensive activities of Riociguat.
Risperidone Injection	Risperidone Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Risperidone.
Dinutuximab Injection	Dinutuximab Injection Butabarbital may increase the hypotensive activities of Dinutuximab.
Haloperidol Injection	Haloperidol Injection The risk or severity of CNS depression can be increased when Butabarbital is combined with Haloperidol.
Amiloride	Amiloride Amiloride may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Butabarbital may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin	Flibanserin The risk or severity of adverse effects can be increased when Butabarbital is combined with Flibanserin.
Brexpiprazole	Brexpiprazole The risk or severity of adverse effects can be increased when Butabarbital is combined with Brexpiprazole.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Ziprasidone.
Cariprazine	Cariprazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Cariprazine.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Butabarbital may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The risk or severity of constipation can be increased when Butabarbital is combined with Eluxadoline.
Ixazomib	Ixazomib Butabarbital may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad	Lesinurad Butabarbital may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Brivaracetam Injection	Brivaracetam Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Brivaracetam.
Pimavanserin	Pimavanserin The risk or severity of adverse effects can be increased when Butabarbital is combined with Pimavanserin.
Diphenhydramine Injection	Diphenhydramine Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Diphenhydramine.
Furosemide Injection	Furosemide Injection Butabarbital may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection	Lixisenatide Injection Butabarbital may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia)	Doxepin (Insomnia) Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Plecanatide	Plecanatide The therapeutic efficacy of Plecanatide can be decreased when used in combination with Butabarbital.
Deutetrabenazine	Deutetrabenazine The risk or severity of sedation and somnolence can be increased when Butabarbital is combined with Deutetrabenazine.
Valbenazine	Valbenazine Butabarbital may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide	Safinamide The risk or severity of adverse effects can be increased when Butabarbital is combined with Safinamide.
Naldemedine	Naldemedine Butabarbital may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole	Benznidazole Butabarbital may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin	Delafloxacin Butabarbital may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Tetrabenazine	Tetrabenazine The risk or severity of sedation and somnolence can be increased when Butabarbital is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin Ertugliflozin may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection	Buprenorphine Injection Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide	Apalutamide Butabarbital may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib	Baricitinib Butabarbital may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine	Lofexidine The therapeutic efficacy of Butabarbital can be increased when used in combination with Lofexidine.
Plazomicin Injection	Plazomicin Injection Butabarbital may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol	Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Butabarbital.
Stiripentol	Stiripentol The risk or severity of adverse effects can be increased when Butabarbital is combined with Stiripentol.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection Butabarbital may increase the hypotensive activities of Paclitaxel.
Prucalopride	Prucalopride Butabarbital may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Magnesium Citrate	Magnesium Citrate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Butabarbital.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Brexanolone Injection	Brexanolone Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Brexanolone.
Solriamfetol	Solriamfetol The risk or severity of adverse effects can be increased when Butabarbital is combined with Solriamfetol.
Pitolisant	Pitolisant Butabarbital may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Phenytoin Injection	Phenytoin Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Phenytoin.
Fosphenytoin Injection	Fosphenytoin Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Fosphenytoin.
Lumateperone	Lumateperone The risk or severity of adverse effects can be increased when Butabarbital is combined with Lumateperone.
Lasmiditan	Lasmiditan The risk or severity of adverse effects can be increased when Butabarbital is combined with Lasmiditan.
Lemborexant	Lemborexant The risk or severity of adverse effects can be increased when Butabarbital is combined with Lemborexant.
Fenfluramine	Fenfluramine The risk or severity of adverse effects can be increased when Butabarbital is combined with Fenfluramine.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Viloxazine.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Theophylline	Theophylline The serum concentration of Theophylline can be decreased when it is combined with Butabarbital.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid Mefenamic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Naproxen	Naproxen Naproxen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of adverse effects can be increased when Butabarbital is combined with Trazodone.
Isotretinoin	Isotretinoin Butabarbital may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Butabarbital may decrease the excretion rate of Sucralfate which could result in a higher serum level.
Floxuridine	Floxuridine Butabarbital may decrease the excretion rate of Floxuridine which could result in a higher serum level.
Phenobarbital	Phenobarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Phenobarbital.
Metaxalone	Metaxalone The risk or severity of adverse effects can be increased when Butabarbital is combined with Metaxalone.
Methotrexate Injection	Methotrexate Injection Methotrexate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Levorphanol	Levorphanol The risk or severity of adverse effects can be increased when Butabarbital is combined with Levorphanol.
Primidone	Primidone The risk or severity of adverse effects can be increased when Butabarbital is combined with Primidone.
Methsuximide	Methsuximide The risk or severity of adverse effects can be increased when Butabarbital is combined with Methsuximide.
Diethylpropion	Diethylpropion The risk or severity of adverse effects can be increased when Butabarbital is combined with Diethylpropion.
Chlorpromazine	Chlorpromazine Chlorpromazine may increase the hypotensive activities of Butabarbital.
Diazepam	Diazepam The risk or severity of adverse effects can be increased when Butabarbital is combined with Diazepam.
Oxazepam	Oxazepam The risk or severity of adverse effects can be increased when Butabarbital is combined with Oxazepam.
Flurazepam	Flurazepam The risk or severity of adverse effects can be increased when Butabarbital is combined with Flurazepam.
Clorazepate	Clorazepate The risk or severity of adverse effects can be increased when Butabarbital is combined with Clorazepic acid.
Lorazepam	Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Butabarbital.
Phenoxybenzamine	Phenoxybenzamine Butabarbital may increase the hypotensive activities of Phenoxybenzamine.
Carmustine	Carmustine Butabarbital may decrease the excretion rate of Carmustine which could result in a higher serum level.
Amantadine	Amantadine Butabarbital may decrease the excretion rate of Amantadine which could result in a higher serum level.
Codeine	Codeine The risk or severity of adverse effects can be increased when Butabarbital is combined with Codeine.
Meprobamate	Meprobamate The risk or severity of adverse effects can be increased when Butabarbital is combined with Meprobamate.
Chlordiazepoxide	Chlordiazepoxide The risk or severity of adverse effects can be increased when Butabarbital is combined with Chlordiazepoxide.
Bromocriptine	Bromocriptine The risk or severity of adverse effects can be increased when Butabarbital is combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The risk or severity of adverse effects can be increased when Butabarbital is combined with Tranylcypromine.
Phenelzine	Phenelzine The risk or severity of adverse effects can be increased when Butabarbital is combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Procarbazine.
Ergoloid Mesylates	Ergoloid Mesylates The risk or severity of adverse effects can be increased when Butabarbital is combined with Ergoloid mesylate.
Tetracycline	Tetracycline Butabarbital may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline	Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Prochlorperazine	Prochlorperazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Prochlorperazine.
Thioridazine	Thioridazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Thioridazine.
Trifluoperazine	Trifluoperazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Trifluoperazine.
Bleomycin	Bleomycin Butabarbital may decrease the excretion rate of Bleomycin which could result in a higher serum level.
Sulfadiazine	Sulfadiazine Butabarbital may decrease the excretion rate of Sulfadiazine which could result in a higher serum level.
Oxycodone	Oxycodone The risk or severity of adverse effects can be increased when Butabarbital is combined with Oxycodone.
Methadone	Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Butabarbital.
Oxybutynin	Oxybutynin Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine	Benztropine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline	Maprotiline Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen	Ibuprofen Ibuprofen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Trihexyphenidyl	Trihexyphenidyl Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine	Orphenadrine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine	Perphenazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Perphenazine.
Azathioprine	Azathioprine Butabarbital may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine	Fluphenazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Fluphenazine.
Methylphenidate	Methylphenidate Butabarbital may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine	Amoxapine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Amoxapine.
Sulfasalazine	Sulfasalazine Sulfasalazine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Mechlorethamine	Mechlorethamine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Mechlorethamine.
Pyridostigmine	Pyridostigmine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Pyridostigmine.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Carbamazepine	Carbamazepine Butabarbital may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Molindone	Molindone The risk or severity of adverse effects can be increased when Butabarbital is combined with Molindone.
Methyldopa	Methyldopa Butabarbital may increase the hypotensive activities of Methyldopa.
Clonidine	Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Butabarbital.
Prazosin	Prazosin Butabarbital may increase the hypotensive activities of Prazosin.
Hydralazine	Hydralazine Butabarbital may increase the hypotensive activities of Hydralazine.
Cimetidine	Cimetidine Butabarbital may decrease the excretion rate of Cimetidine which could result in a higher serum level.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Warfarin	Warfarin Butabarbital may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam	Clonazepam The risk or severity of adverse effects can be increased when Butabarbital is combined with Clonazepam.
Loperamide	Loperamide The metabolism of Loperamide can be increased when combined with Butabarbital.
Promethazine	Promethazine The risk or severity of adverse effects can be increased when Butabarbital is combined with Promethazine.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Nitrofurantoin	Nitrofurantoin Butabarbital may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin	Griseofulvin The serum concentration of Griseofulvin can be decreased when it is combined with Butabarbital.
Digoxin	Digoxin Butabarbital may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine	Loxapine The risk or severity of adverse effects can be increased when Butabarbital is combined with Loxapine.
Chloroquine	Chloroquine Butabarbital may decrease the excretion rate of Chloroquine which could result in a higher serum level.
Quinine	Quinine The risk or severity of adverse effects can be increased when Butabarbital is combined with Quinine.
Ethosuximide	Ethosuximide The risk or severity of adverse effects can be increased when Butabarbital is combined with Ethosuximide.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Lactulose	Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Butabarbital.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Butabarbital may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital	Secobarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Secobarbital.
Desipramine	Desipramine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline	Amitriptyline Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine	Imipramine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid	Probenecid Butabarbital may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine	Quinidine Butabarbital may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide	Procainamide Procainamide may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Isoniazid	Isoniazid Butabarbital may decrease the excretion rate of Isoniazid which could result in a higher serum level.
Pyrazinamide	Pyrazinamide Butabarbital may decrease the excretion rate of Pyrazinamide which could result in a higher serum level.
Disopyramide	Disopyramide Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid	Valproic Acid The serum concentration of Valproic acid can be increased when it is combined with Butabarbital.
Liothyronine	Liothyronine Butabarbital may decrease the excretion rate of Liothyronine which could result in a higher serum level.
Methimazole	Methimazole Butabarbital may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide	Chlorpropamide Butabarbital may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide	Tolbutamide Butabarbital may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide	Tolazamide Butabarbital may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan	Dextromethorphan The risk or severity of adverse effects can be increased when Butabarbital is combined with Dextromethorphan.
Cyclobenzaprine	Cyclobenzaprine The risk or severity of CNS depression can be increased when Butabarbital is combined with Cyclobenzaprine.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Butabarbital.
Doxylamine	Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Cyproheptadine	Cyproheptadine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine	Clemastine The risk or severity of adverse effects can be increased when Butabarbital is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The risk or severity of adverse effects can be increased when Butabarbital is combined with Chlorpheniramine.
Brompheniramine	Brompheniramine The risk or severity of adverse effects can be increased when Butabarbital is combined with Dexbrompheniramine.
Meclizine	Meclizine The risk or severity of adverse effects can be increased when Butabarbital is combined with Meclizine.
Ethambutol	Ethambutol Butabarbital may decrease the excretion rate of Ethambutol which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Dantrolene	Dantrolene The risk or severity of adverse effects can be increased when Butabarbital is combined with Dantrolene.
Chlorzoxazone	Chlorzoxazone The risk or severity of adverse effects can be increased when Butabarbital is combined with Chlorzoxazone.
Carisoprodol	Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Butabarbital.
Methocarbamol	Methocarbamol The risk or severity of adverse effects can be increased when Butabarbital is combined with Methocarbamol.
Pyridoxine	Pyridoxine The metabolism of Butabarbital can be increased when combined with Pyridoxine.
Folic Acid	Folic Acid Folic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Butabarbital may increase the hypotensive activities of Propranolol.
Minoxidil	Minoxidil Butabarbital may increase the hypotensive activities of Minoxidil.
Nortriptyline	Nortriptyline Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Nortriptyline.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Butabarbital which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Mercaptopurine	Mercaptopurine The serum concentration of Mercaptopurine can be decreased when it is combined with Butabarbital.
Phytonadione	Phytonadione Butabarbital may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Nadolol	Nadolol Butabarbital may increase the hypotensive activities of Nadolol.
Butorphanol Injection	Butorphanol Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The risk or severity of adverse effects can be increased when Butabarbital is combined with Nalbuphine.
Allopurinol	Allopurinol Butabarbital may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Trimethobenzamide	Trimethobenzamide The risk or severity of adverse effects can be increased when Butabarbital is combined with Trimethobenzamide.
Flavoxate	Flavoxate Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Papaverine	Papaverine Butabarbital may increase the hypotensive activities of Papaverine.
Colchicine	Colchicine Butabarbital may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Dacarbazine	Dacarbazine Butabarbital may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide	Acetazolamide The risk or severity of adverse effects can be increased when Butabarbital is combined with Acetazolamide.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Pyrantel	Pyrantel The risk or severity of adverse effects can be increased when Butabarbital is combined with Pyrantel.
Thiotepa Injection	Thiotepa Injection The therapeutic efficacy of Butabarbital can be decreased when used in combination with Thiotepa.
Captopril	Captopril Butabarbital may increase the hypotensive activities of Captopril.
Dipyridamole	Dipyridamole Butabarbital may increase the hypotensive activities of Dipyridamole.
Isoxsuprine	Isoxsuprine Butabarbital may increase the hypotensive activities of Isoxsuprine.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Metoprolol	Metoprolol Butabarbital may increase the hypotensive activities of Metoprolol.
Hydroxyzine	Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Butabarbital.
Thiothixene	Thiothixene The risk or severity of adverse effects can be increased when Butabarbital is combined with Thiothixene.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Alprazolam	Alprazolam The risk or severity of adverse effects can be increased when Butabarbital is combined with Alprazolam.
Temazepam	Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Butabarbital.
Triazolam	Triazolam The risk or severity of adverse effects can be increased when Butabarbital is combined with Triazolam.
Dicyclomine	Dicyclomine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine	Hyoscyamine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline	Propantheline Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim	Trimethoprim Butabarbital may decrease the excretion rate of Trimethoprim which could result in a higher serum level.
Diltiazem	Diltiazem Butabarbital may increase the hypotensive activities of Diltiazem.
Nifedipine	Nifedipine Butabarbital may increase the hypotensive activities of Nifedipine.
Timolol	Timolol Butabarbital may increase the hypotensive activities of Timolol.
Verapamil	Verapamil Butabarbital may increase the hypotensive activities of Verapamil.
Atenolol	Atenolol Butabarbital may increase the hypotensive activities of Atenolol.
Pindolol	Pindolol The risk or severity of adverse effects can be increased when Butabarbital is combined with Pindolol.
Cisplatin Injection	Cisplatin Injection Cisplatin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Diflunisal	Diflunisal Diflunisal may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Piroxicam	Piroxicam Piroxicam may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Bumetanide	Bumetanide Butabarbital may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Glipizide	Glipizide Butabarbital may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide	Indapamide Butabarbital may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Butabarbital may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection	Oxacillin Injection Butabarbital may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline The serum concentration of Pentoxifylline can be decreased when it is combined with Butabarbital.
Pentamidine Injection	Pentamidine Injection Pentamidine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Labetalol	Labetalol Butabarbital may increase the hypotensive activities of Labetalol.
Auranofin	Auranofin Butabarbital may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection Leuprolide may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Gemfibrozil	Gemfibrozil Butabarbital may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Ketoprofen	Ketoprofen Ketoprofen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Pimozide	Pimozide The risk or severity of adverse effects can be increased when Butabarbital is combined with Pimozide.
Enalapril	Enalapril Butabarbital may increase the hypotensive activities of Enalapril.
Flurbiprofen	Flurbiprofen Flurbiprofen may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Amiodarone	Amiodarone Butabarbital may increase the hypotensive activities of Amiodarone.
Aztreonam Injection	Aztreonam Injection Butabarbital may decrease the excretion rate of Aztreonam which could result in a higher serum level.
Buspirone	Buspirone Butabarbital may decrease the excretion rate of Buspirone which could result in a higher serum level.
Ciprofloxacin	Ciprofloxacin Butabarbital may decrease the excretion rate of Ciprofloxacin which could result in a higher serum level.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Diclofenac	Diclofenac Diclofenac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Fluoxetine	Fluoxetine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Fluoxetine.
Nimodipine	Nimodipine Butabarbital may increase the hypotensive activities of Nimodipine.
Clozapine	Clozapine The risk or severity of adverse effects can be increased when Butabarbital is combined with Clozapine.
Estazolam	Estazolam The risk or severity of adverse effects can be increased when Butabarbital is combined with Estazolam.
Didanosine	Didanosine Butabarbital may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection	Pentostatin Injection Butabarbital may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril	Benazepril Butabarbital may increase the hypotensive activities of Benazepril.
Etodolac	Etodolac Etodolac may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Felodipine	Felodipine Butabarbital may increase the hypotensive activities of Felodipine.
Fosinopril	Fosinopril Butabarbital may increase the hypotensive activities of Fosinopril.
Nabumetone	Nabumetone Nabumetone may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Quinapril	Quinapril Butabarbital may increase the hypotensive activities of Quinapril.
Ramipril	Ramipril Ramipril may increase the hypotensive activities of Butabarbital.
Amlodipine	Amlodipine Butabarbital may increase the hypotensive activities of Amlodipine.
Teniposide Injection	Teniposide Injection The serum concentration of Teniposide can be decreased when it is combined with Butabarbital.
Lisinopril	Lisinopril Butabarbital may increase the hypotensive activities of Lisinopril.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Sotalol	Sotalol Butabarbital may increase the hypotensive activities of Sotalol.
Bisoprolol	Bisoprolol Butabarbital may increase the hypotensive activities of Bisoprolol.
Zolpidem	Zolpidem Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Doxazosin	Doxazosin Butabarbital may increase the hypotensive activities of Doxazosin.
Terazosin	Terazosin Butabarbital may increase the hypotensive activities of Terazosin.
Isradipine	Isradipine Butabarbital may increase the hypotensive activities of Isradipine.
Cisapride	Cisapride The risk or severity of adverse effects can be increased when Butabarbital is combined with Cisapride.
Gabapentin	Gabapentin The risk or severity of adverse effects can be increased when Butabarbital is combined with Gabapentin.
Venlafaxine	Venlafaxine The risk or severity of adverse effects can be increased when Butabarbital is combined with Venlafaxine.
Nizatidine	Nizatidine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Nizatidine.
Fluvoxamine	Fluvoxamine The risk or severity of adverse effects can be increased when Butabarbital is combined with Fluvoxamine.
Nefazodone	Nefazodone The risk or severity of adverse effects can be increased when Butabarbital is combined with Nefazodone.
Lamotrigine	Lamotrigine The serum concentration of Lamotrigine can be decreased when it is combined with Butabarbital.
Losartan	Losartan Butabarbital may increase the hypotensive activities of Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Tramadol	Tramadol The risk or severity of CNS depression can be increased when Butabarbital is combined with Tramadol.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Moexipril	Moexipril Butabarbital may increase the hypotensive activities of Moexipril.
Ifosfamide Injection	Ifosfamide Injection Butabarbital may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine	Nicardipine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion	Bupropion The risk or severity of adverse effects can be increased when Butabarbital is combined with Bupropion.
Ticlopidine	Ticlopidine Ticlopidine may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Metformin	Metformin Butabarbital may decrease the excretion rate of Metformin which could result in a higher serum level.
Nisoldipine	Nisoldipine Butabarbital may increase the hypotensive activities of Nisoldipine.
Lamivudine	Lamivudine Butabarbital may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole	Riluzole The risk or severity of adverse effects can be increased when Butabarbital is combined with Riluzole.
Amifostine Injection	Amifostine Injection Butabarbital may increase the hypotensive activities of Amifostine.
Acarbose	Acarbose Butabarbital may decrease the excretion rate of Acarbose which could result in a higher serum level.
Gemcitabine Injection	Gemcitabine Injection Butabarbital may decrease the excretion rate of Gemcitabine which could result in a higher serum level.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Butabarbital may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine	Clomipramine The risk or severity of adverse effects can be increased when Butabarbital is combined with Clomipramine.
Fosfomycin	Fosfomycin Butabarbital may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Trandolapril	Trandolapril Butabarbital may increase the hypotensive activities of Trandolapril.
Topiramate	Topiramate The risk or severity of adverse effects can be increased when Butabarbital is combined with Topiramate.
Valsartan	Valsartan Butabarbital may increase the hypotensive activities of Valsartan.
Pramipexole	Pramipexole Butabarbital may increase the sedative activities of Pramipexole.
Donepezil	Donepezil The therapeutic efficacy of Butabarbital can be decreased when used in combination with Donepezil.
Loratadine	Loratadine Butabarbital may increase the anticholinergic activities of Loratadine.
Carvedilol	Carvedilol Butabarbital may increase the hypotensive activities of Carvedilol.
Nilutamide	Nilutamide Butabarbital may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide	Flutamide Butabarbital may decrease the excretion rate of Flutamide which could result in a higher serum level.
Selegiline	Selegiline The risk or severity of adverse effects can be increased when Butabarbital is combined with Selegiline.
Sertraline	Sertraline The risk or severity of adverse effects can be increased when Butabarbital is combined with Sertraline.
Propafenone	Propafenone The serum concentration of Propafenone can be decreased when it is combined with Butabarbital.
Irbesartan	Irbesartan Butabarbital may increase the hypotensive activities of Irbesartan.
Tamsulosin	Tamsulosin Butabarbital may increase the hypotensive activities of Tamsulosin.
Ropinirole	Ropinirole Butabarbital may increase the sedative activities of Ropinirole.
Quetiapine	Quetiapine The risk or severity of adverse effects can be increased when Butabarbital is combined with Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of adverse effects can be increased when Butabarbital is combined with Cetirizine.
Paroxetine	Paroxetine The risk or severity of adverse effects can be increased when Butabarbital is combined with Paroxetine.
Tolcapone	Tolcapone The risk or severity of adverse effects can be increased when Butabarbital is combined with Tolcapone.
Citalopram	Citalopram The risk or severity of adverse effects can be increased when Butabarbital is combined with Citalopram.
Capecitabine	Capecitabine Butabarbital may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz	Efavirenz The risk or severity of adverse effects can be increased when Butabarbital is combined with Efavirenz.
Abacavir	Abacavir Butabarbital may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib	Celecoxib Celecoxib may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Rosiglitazone	Rosiglitazone Butabarbital may decrease the excretion rate of Rosiglitazone which could result in a higher serum level.
Tolterodine	Tolterodine Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide	Thalidomide Butabarbital may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Butabarbital which could result in a higher serum level.
Nateglinide	Nateglinide Butabarbital may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Galantamine	Galantamine The therapeutic efficacy of Butabarbital can be decreased when used in combination with Galantamine.
Levetiracetam	Levetiracetam The risk or severity of adverse effects can be increased when Butabarbital is combined with Levetiracetam.
Rabeprazole	Rabeprazole Butabarbital may decrease the excretion rate of Rabeprazole which could result in a higher serum level.