Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate is a balanced salt (isotonic) solution used for irrigation only, never for injection.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 1 clinical label set within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Tis-u-sol is a prescription balanced salt solution used only for irrigation (rinsing or flushing tissue), an older standby on the U.S. market since about 1982, mostly handled by clinicians during surgery and other procedures. Because it is isotonic, meaning its salts match the balance of body fluids, it rinses gently, and most people notice little beyond the feel of the flush. The one thing to get right is that it is for irrigation only and must never be injected into a vein or muscle. Use it exactly as your physician directs, only if it is clear with the seal intact, and discard any leftover.
Clinical pearls
- Its potassium, magnesium and phosphate salts are there to mirror body fluids, not to treat a low electrolyte level.
- Store it apart from IV bags and injectable fluids so an irrigation container is never mistaken for one.
- Never pour unused solution back into the container or keep an opened one for a later rinse.
Patient information guide A plain-language walkthrough of Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate, written from its FDA label.
What Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate is used for
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This ingredient combination is supported here as an irrigation solution.
- Tis-u-sol is an isotonic solution for irrigation only.
- It is not for injection.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate dosage
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Tis-u-sol is used as directed by a physician. It is a prescription (Rx only) irrigation solution.
- It may be warmed in an oven to no more than 50°C for a maximum of 60 days.
- Discard it after 60 days of warming.
- Discard any unused portion after use.
Dosing details from the FDA-approved label
From the Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- General use
- As directed by a physician
- Warm in oven to not more than 50°C for a maximum of 60 days. Discard after 60 days of warming. Do not use unless solution is clear and seal is intact. Discard unused portion.
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION For complete information on preparation before colonoscopy and administration of the dosage regimen, see full prescribing information. ( 2.1 , 2.2 ) Preparation and Administration ( 2.1 ) Administration of two doses (24 tablets) are required for a complete preparation for colonoscopy. SUTAB is supplied as two bottles each containing 12 tablets. Twelve (12) tablets are equivalent to one dose. Each SUTAB bottle contains a desiccant. Remove and discard the desiccant from both bottles the evening prior to the colonoscopy. Must consume water with each dose and an additional 32 ounces of water after each dose. Do not take other laxatives. Administer oral medications at least 1 hour before starting each dose of SUTAB. If taking tetracycline or fluoroquinolone antibiotics, iron, digoxin, chlorpromazine, or penicillamine, take these medications at least 2 hours before and not less than 6 hours after administration of each dose. Recommended Split Dose (2-Day) Regimen ( 2.2 ) Day 1, Dose 1: On the Evening Prior to Colonoscopy Open 1 bottle of 12 tablets. Remove and discard the desiccant. Remove and discard the desiccant from the second bottle and close the bottle. Use the second bottle for the second dose on the morning of the colonoscopy. Fill the provided container with 16 ounces of water (up to the fill line). Swallow each tablet with a sip of water and drink the entire amount over 15 to 20 minutes. Approximately one hour after the last tablet is ingested, fill the provided container a second time with 16 ounces of water (up to the fill line) and drink the entire amount over 30 minutes. Approximately 30 minutes after finishing the second container of water, fill the provided container with 16 ounces of water (up to the fill line) and drink the entire amount over 30 minutes. Day 2, Dose 2: Morning of the Colonoscopy (5 to 8 hours prior to the colonoscopy and no sooner than 4 hours from starting Dose 1): Continue to consume only clear liquids until after the colonoscopy. Repeat Step 2 to Step 4 from Day 1, Dose 1. If patients experience preparation-related symptoms (e.g., nausea, bloating, cramping), pause or slow the rate of drinking the additional water until symptoms diminish. Complete all SUTAB tablets and water at least two hours prior to colonoscopy.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate warnings and precautions
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- For irrigation only. Not for injection.
- Do not use unless the solution is clear and the seal is intact.
- Do not warm above 50°C, and discard after 60 days of warming.
- Discard any unused portion.
Before taking Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate
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- Use only as directed by a physician.
- Never use it as an injection.
How to store Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate
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Store at 20º to 25°C (68º to 77°F).
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate — the kind of thing our pharmacy team would talk through with you at the counter.
What is this solution used for?
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Can it be injected?
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How do I know it is safe to use?
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Can the solution be warmed?
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What should I do with leftover solution?
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Is Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate available over the counter?
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When was Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate first available?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate on HelloPharmacist
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate forms and strengths (how it comes)
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate is available in 1 form. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate inactive ingredients by manufacturer.
Other oral form
How this form is used
- Tis-u-sol is an isotonic solution for irrigation only.
- Tis-u-sol is used as directed by a physician.
- Tis-u-sol is not for injection.
- Tis-u-sol may be warmed in an oven to no more than 50°C for a maximum of 60 days, then discarded after 60 days of warming.
- Do not use Tis-u-sol unless the solution is clear and the seal is intact. Discard any unused portion.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate on the U.S. market: products, makers and brands
How Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
1 company lists 1 Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate product record with the FDA, mostly as other oral form; the earliest marketing or approval year on record is 1982. Brand names on the directory include Tis-u-sol, Sutab; the rest are generics.
Compare Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate products
A representative set of FDA-listed product records for Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Other oral form | ||||
| SODIUM CHLORIDE 800 mg/100 mL; POTASSIUM CHLORIDE 40 mg/100 mL; MAGNESIUM SULFATE HEPTAHYDRATE 20 mg/100 mL; SODIUM PHOSPHATE, DIBASIC, HEPTAHYDRATE 8.75 mg/100 mL; MONOBASIC POTASSIUM PHOSPHATE 6.25 mg/100 mL | Irrigation | Baxter Healthcare Corporation | NDA | View NDC → |
Showing 1 of 1 products — FDA National Drug Code Directory. See every product, package size and price: browse all 1 Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate NDCs →
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate FDA approval history
How Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list no Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate recalls since July 2021.
✅No Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate recalls on record since July 2021Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one exact multiple-ingredient concept (MIN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). A product with a different ingredient combination belongs on a different page.
RxCUI 1008228 1 dose form · 1 strength
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Dose form (SCDF) Irrigation Solution RxCUI 801441No current FDA listingClinical drug / strength (SCD) magnesium sulfate 0.2 MG/ML / monobasic potassium phosphate 0.063 MG/ML / potassium chloride 0.005 MEQ/ML / sodium chloride 0.14 MEQ/ML / sodium phosphate dihydrate 0.088 MG/MLRxCUI 801442
Look up RxCUI 1008228 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate supply and shortage status
Whether Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate brand names
Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate is sold under 2 brand names in the FDA directory — Tis-u-sol, Sutab. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate: manufacturers and labelers
One company lists Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate products with the FDA. By number of product records, the largest are Baxter Healthcare Corporation. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Sources for this Magnesium Sulfate / Potassium Chloride / Potassium Phosphate / Sodium Chloride / Sodium Phosphate page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Braintree Laboratories, Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →