Skip to the answer

Ziprasidone

Ziprasidone is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder (manic or mixed episodes, plus maintenance with lithium or valproate), and as an injection for sudden agitation in schizophrenia.

Brand names GeodonZiprasidone Mesylate 20 mg/mL
Drug class Atypical Antipsychotic
Rx Forms 2
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 39 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

How we combine label and product data →
✓No current FDA shortage listed · checked Oct 3, 2026
Other forms & routes:
Injection
Ziprasidone at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

Ziprasidone (Geodon), on the market since about 2001 and available as a generic, is an atypical antipsychotic that blocks dopamine and serotonin receptors to treat schizophrenia and bipolar I disorder; an injection form calms sudden agitation. It causes less weight gain than many in its class, and sleepiness, dizziness and restlessness are what people notice most. Its boxed warning covers a higher risk of death in older adults with dementia-related psychosis, a use it is not approved for. Heart rhythm is its other big concern, since it prolongs the QT interval (the heart's electrical reset) more than several other antipsychotics, so review heart conditions and medicines with your prescriber.

Clinical pearls

  • Take the capsules with a full meal rather than a snack, because food can double how much is absorbed.
  • Swallow the capsules whole, never opening, crushing or chewing them.
  • Expect possible blood tests for potassium and magnesium, since low levels make its heart rhythm effect more dangerous.
  • Mention ziprasidone before starting any new medicine, since QT-prolonging drugs like moxifloxacin, sotalol and pimozide should not be combined with it.
How we write & review this content — our editorial policy →
⚠️ FDA Boxed Warning — the FDA’s strongest safety alert ▾

Older adults with dementia-related psychosis who take antipsychotic drugs have a higher risk of death. Most deaths in studies appeared to be from heart-related causes (such as heart failure or sudden death) or infections (such as pneumonia).

Ziprasidone mesylate for injection is not approved for dementia-related psychosis. If you care for an older person with dementia who takes this medicine, talk with their prescriber.

Read the full warning on DailyMed →
How you get itPrescription only
Comes asCapsule, Injection
Earliest FDA record2001
Companies listing it with the FDA42
FDA label last updatedJan 13, 2025
FDA’s strongest warning (boxed)Yes, read the warning

Patient information guide — a plain-language walkthrough of Ziprasidone, written from its FDA label.

What Ziprasidone is used for

▾

Ziprasidone is used for several mental health conditions in adults.

  • Schizophrenia (Geodon capsules and ziprasidone capsules).
  • Acute manic or mixed episodes of bipolar I disorder, used alone (capsules).
  • Maintenance treatment of bipolar I disorder, added to lithium or valproate (capsules).
  • Acute agitation in schizophrenia (Geodon for injection and ziprasidone mesylate for injection, given into a muscle).

How Ziprasidone works

▾

Ziprasidone is an atypical antipsychotic. It is thought to work by blocking dopamine type 2 and serotonin type 2 receptors in the brain.

It also binds to several other receptors and blocks reuptake of serotonin and norepinephrine, two brain chemicals.

Ziprasidone dosage

▾

Ziprasidone capsules are generally taken by mouth twice a day with food, swallowed whole. Your prescriber usually adjusts the dose gradually and uses the lowest effective dose.

The injection is given into a muscle by a healthcare professional only when needed for acute agitation. Follow your prescriber and the product label. Ask your pharmacist what to do if you miss a dose.

Dosing details from the FDA-approved label

From the Ziprasidone prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Schizophrenia (oral capsules)
    • Initiate at 20 mg twice daily with food
    • Daily dosage may be adjusted on the basis of individual clinical status up to 80 mg twice daily
    • Adjustments generally at intervals of not less than 2 days
    • Maximum: An increase to a dose greater than 80 mg twice daily is not generally recommended; safety of doses above 100 mg twice daily has not been systematically evaluated
    • Administer with food; swallow capsules whole, do not open, crush, or chew
  • Acute treatment of manic or mixed episodes of bipolar I disorder (adults, oral)
    • Initial daily dose of 40 mg twice daily with food
    • May be increased to 60 mg or 80 mg twice daily on the second day of treatment, then adjusted on the basis of tolerance and efficacy within the range 40 mg-80 mg twice daily
    • Administer with food
  • Maintenance treatment of bipolar I disorder as an adjunct to lithium or valproate
    • Continue treatment at the same dose on which the patient was initially stabilized, within the range of 40 mg-80 mg twice daily with food
    • Administer with food
  • Acute treatment of agitation in schizophrenia (intramuscular)
    • 10 mg to 20 mg administered as required
    • Doses of 10 mg may be administered every two hours
    • Doses of 20 mg may be administered every four hours
    • Maximum: 40 mg per day
    • Intramuscular use only, not intravenous; intramuscular administration for more than three consecutive days has not been studied
Read the label’s full dosing text

2 DOSAGE AND ADMINISTRATION • Administer capsules orally with food. Do not open, crush, or chew. ( 2.1 ) • Schizophrenia: Initiate at 20 mg twice daily. Daily dosage may be adjusted up to 80 mg twice daily. Dose adjustments should occur at intervals of not less than 2 days. Safety and efficacy has been demonstrated in doses up to 100 mg twice daily. The lowest effective dose should be used. ( 2.2 ) • Acute treatment of manic/mixed episodes of bipolar I disorder: Initiate at 40 mg twice daily. Increase to 60 mg or 80 mg twice daily on day 2 of treatment. Subsequent dose adjustments should be based on tolerability and efficacy within the range of 40-80 mg twice daily. ( 2.3 ) • Maintenance treatment of bipolar I disorder as an adjunct to lithium or valproate: Continue treatment at the same dose on which the patient was initially stabilized, within the range of 40-80 mg twice daily. ( 2.3 ) • Acute treatment of agitation associated with schizophrenia (intramuscular administration): 10 mg-20 mg up to a maximum dose of 40 mg per day. Doses of 10 mg may be administered every 2 hours. Doses of 20 mg may be administered every 4 hours. ( 2.4 ) 2.1 Administration Information for GEODON Capsules Administer GEODON capsules orally with food. Swallow capsules whole, do not open, crush, or chew the capsules. 2.2 Schizophrenia Dose Selection GEODON capsules should be administered at an initial daily dose of 20 mg twice daily with food. In some patients, daily dosage may subsequently be adjusted on the basis of individual clinical status up to 80 mg twice daily. Dosage adjustments, if indicated, should generally occur at intervals of not less than 2 days, as steady-state is achieved within 1 to 3 days. In order to ensure use of the lowest effective dose, patients should ordinarily be observed for improvement for several weeks before upward dosage adjustment. Efficacy in schizophrenia was demonstrated in a dose range of 20 mg to 100 mg twice daily in short-term, placebo-controlled clinical trials. There were trends toward dose response within the range of 20 mg to 80 mg twice daily, but results were not consistent. An increase to a dose greater than 80 mg twice daily is not generally recommended. The safety of doses above 100 mg twice daily has not been systematically evaluated in clinical trials [see Clinical Studies (14.1) ] .

Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →

Ziprasidone side effects

▾

Common side effects

  • Sleepiness (somnolence)
  • Respiratory tract infection (in schizophrenia studies)
  • Movement-related symptoms such as tremor or stiffness (extrapyramidal symptoms)
  • Dizziness or lightheadedness
  • Restlessness (akathisia)
  • Abnormal vision
  • Weakness (asthenia)
  • Vomiting

When to get medical help

  • Seek help right away for fainting, dizziness, or a racing or irregular heartbeat, which could signal a dangerous heart rhythm problem (QT prolongation).
  • Get urgent care for high fever, severe muscle stiffness, confusion, or sweating with a fast or irregular heartbeat, which can be signs of neuroleptic malignant syndrome.
  • Call right away for agitation, hallucinations, fever, tremor, muscle rigidity, or severe nausea, vomiting or diarrhea, which can be signs of serotonin syndrome.
  • Stop the medicine and get help for a widespread skin rash, blistering, or rash with fever or swelling. Serious skin reactions can be fatal.
  • Tell your doctor about any new rash with no clear cause.
  • Report uncontrolled movements of the face, tongue or body (tardive dyskinesia).
  • Report signs of high blood sugar such as increased thirst, urination or hunger, and weakness.
  • Report fever or infection signs, since white blood cell counts can drop.

The most common side effects seen in studies were:

  • Sleepiness
  • Movement-related symptoms (tremor, stiffness)
  • Dizziness
  • Restlessness (akathisia)
  • Nausea, vomiting
  • Respiratory tract infection
  • Abnormal vision and weakness
  • With the injection: headache, nausea and sleepiness

Get medical help quickly for fainting, a racing heartbeat, high fever with stiffness, serious skin rash, or suicidal thoughts.

Ziprasidone warnings and precautions

▾
  • Death risk in older adults with dementia-related psychosis (boxed warning).
  • Heart rhythm changes (QT prolongation) and possible sudden death.
  • Serotonin syndrome and neuroleptic malignant syndrome.
  • Serious skin reactions such as DRESS and Stevens-Johnson syndrome.
  • Tardive dyskinesia, blood sugar and weight changes, low blood pressure on standing, low white blood cells, seizures, and suicide risk.

Ziprasidone interactions

▾

Several medicines can clash with ziprasidone.

  • QT-prolonging drugs (such as sotalol, quinidine, thioridazine, pimozide): added heart rhythm risk.
  • MAO inhibitors, including linezolid and IV methylene blue: serotonin syndrome risk.
  • SSRIs, SNRIs, triptans, tramadol, St. John's Wort and similar drugs: higher serotonin syndrome risk.
  • Blood pressure medicines: effects may be enhanced.
  • Levodopa and dopamine agonists: effects may be weakened.
  • Carbamazepine lowers ziprasidone levels; ketoconazole raises them.
  • Food: increases absorption of the capsules up to two-fold.

Interactions listed in the FDA-approved label

From the Ziprasidone prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.

  • Drugs that prolong the QT interval: Ziprasidone should not be used with any drug that prolongs the QT interval. Do not use in combination
  • Other centrally acting drugs: Given the primary CNS effects of ziprasidone, caution is needed when taken in combination with other centrally acting drugs. Use caution
  • Antihypertensive agents: Because of its potential for inducing hypotension, ziprasidone may enhance the effects of certain antihypertensive agents.
  • Levodopa and dopamine agonists: Ziprasidone may antagonize the effects of levodopa and dopamine agonists.
  • Serotonergic drugs (SNRIs, SSRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines, St. John's Wort): Risk of serotonin syndrome with concomitant therapy.
  • Carbamazepine: Carbamazepine, a CYP3A4 inducer, 200 mg twice daily for 21 days decreased the AUC of ziprasidone by approximately 35%; the effect may be greater with higher carbamazepine doses.
  • Ketoconazole: Ketoconazole 400 mg QD for 5 days increased the AUC and Cmax of ziprasidone by about 35 to 40%; other CYP3A4 inhibitors would be expected to have similar effects.
  • Cimetidine: Cimetidine 800 mg QD for 2 days did not affect ziprasidone pharmacokinetics.
  • Antacid (Maalox): Co-administration of 30 mL of Maalox did not affect the pharmacokinetics of ziprasidone.
  • Food: The absorption of ziprasidone is increased up to two-fold in the presence of food. Administer with food
Read the label’s full interactions text

7 DRUG INTERACTIONS Drug-drug interactions can be pharmacodynamic (combined pharmacologic effects) or pharmacokinetic (alteration of plasma levels). The risks of using ziprasidone in combination with other drugs have been evaluated as described below. All interactions studies have been conducted with oral ziprasidone. Based upon the pharmacodynamic and pharmacokinetic profile of ziprasidone, possible interactions could be anticipated: • Ziprasidone should not be used in combination with other drugs that have demonstrated QT prolongation. ( 4.1 , 7.3 ) • The absorption of ziprasidone is increased up to two-fold in the presence of food. ( 7.10 ) • The full prescribing information contains additional drug interactions. (7) . 7.1 Metabolic Pathway Approximately two-thirds of ziprasidone is metabolized via a combination of chemical reduction by glutathione and enzymatic reduction by aldehyde oxidase. There are no known clinically relevant inhibitors or inducers of aldehyde oxidase. Less than one-third of ziprasidone metabolic clearance is mediated by cytochrome P450 catalyzed oxidation. 7.2 In Vitro Studies An in vitro enzyme inhibition study utilizing human liver microsomes showed that ziprasidone had little inhibitory effect on CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4, and thus would not likely interfere with the metabolism of drugs primarily metabolized by these enzymes. There is little potential for drug interactions with ziprasidone due to displacement [see Clinical Pharmacology (12.3) ]. 7.3 Pharmacodynamic Interactions • Ziprasidone should not be used with any drug that prolongs the QT interval [see Contraindications (4.1) ]. • Given the primary CNS effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs. • Because of its potential for inducing hypotension, ziprasidone may enhance the effects of certain antihypertensive agents. • Ziprasidone may antagonize the effects of levodopa and dopamine agonists.

Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →

Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

🌿188 supplements and herbs with documented Ziprasidone interactions, ranked by severity Check Ziprasidone against a supplement or herb →

Before taking Ziprasidone

▾
  • Do not use with a history of QT prolongation, a recent heart attack, or uncompensated heart failure.
  • Do not use if allergic to ziprasidone or taking MAO inhibitors.
  • Tell your doctor about low potassium or magnesium, slow heart rate, seizures, diabetes, or low white blood cell count.
  • Pregnancy: newborns exposed in the third trimester may have movement or withdrawal symptoms.
  • Breastfeeding: it may pass into milk; watch the baby for sleepiness, irritability and poor feeding.
  • Older adults may need a lower starting dose and slower increases.
  • Children: a safe and effective dose has not been established.
  • Liver problems can raise ziprasidone levels; the injection needs caution with kidney problems.

Ziprasidone overdose

▾

In studies, overdoses led to sleepiness, tremor, anxiety, slurred speech and movement symptoms, and all patients survived. There is no specific antidote. Treatment is supportive, with heart monitoring. Call poison control or seek emergency care right away.

What Ziprasidone does in the body

▾

Ziprasidone binds strongly to dopamine D2 and D3, several serotonin, and alpha-1 adrenergic receptors. It blocks D2, 5HT2A and 5HT1D, and activates 5HT1A. It also blocks reuptake of serotonin and norepinephrine and has moderate affinity for histamine H1 receptors.

How your body processes Ziprasidone

▾

Taken by mouth, ziprasidone is well absorbed and peaks in about 6 to 8 hours. Food can double absorption. It is mostly broken down by the liver, with a half-life of about 7 hours. Steady levels are reached in one to three days. Very little is excreted unchanged in urine.

How to store Ziprasidone

▾

stored at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) . stored at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) in dry form. Protect from light.

Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

188

Supplements & herbs that interact with Ziprasidone

188 supplements and herbal products have documented interactions with Ziprasidone in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 11
  • Moderate · 136
  • Minor · 41
ACTIVATED CHARCOAL Major AMERICAN HELLEBORE Major ARSENIC Major CESIUM Major EPHEDRA Major GRAPEFRUIT Major INDIAN SNAKEROOT Major LITHIUM Major +180 more
Every supplement checked against Ziprasidone — ranked by severity The full interaction hub: 11 major · 136 moderate · 41 minor · every one linked to its full report. Check Ziprasidone against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

Ziprasidone: pharmacist answers to common questions

Quick, plain-English answers to the questions patients ask most about Ziprasidone — the kind of thing our pharmacy team would talk through with you at the counter.

What is ziprasidone used for?

▾
It treats schizophrenia and bipolar I disorder in adults. The capsules are used for ongoing treatment, and the injection is used for sudden agitation in schizophrenia. Your prescriber chooses the form that fits your situation.

How should I take the capsules?

▾
Take them by mouth with food, since a meal helps your body absorb the medicine. Swallow them whole. Do not open, crush or chew them. Follow your prescriber's schedule.

What side effects should I expect?

▾
Sleepiness, dizziness, restlessness, tremor or stiffness, nausea and vomiting are common. Be careful with driving or machinery until you know how it affects you. Tell your prescriber if side effects bother you.

When should I call my doctor right away?

▾
Seek help for fainting, a racing or irregular heartbeat, high fever with stiffness, a new rash, uncontrolled movements, or thoughts of suicide. These can be signs of serious reactions.

Can I take it with my other medicines?

▾
Some medicines should not be combined with it, especially other QT-prolonging drugs and MAO inhibitors. Antidepressants and other serotonin-boosting drugs raise serotonin syndrome risk. Give your pharmacist a full list of your medicines and supplements.

Is it safe in pregnancy?

▾
Babies exposed during the third trimester may have movement or withdrawal symptoms after birth. Untreated illness also carries risks, so talk with your doctor before changing anything.

Is Ziprasidone available over the counter?

▾
No. Ziprasidone is a prescription medicine: every Ziprasidone product listed with the FDA is prescription only, so it is not sold over the counter. Your prescriber decides whether it is appropriate for you, and your pharmacist dispenses it.

When was Ziprasidone first available?

▾
The earliest FDA record we hold for Ziprasidone is from 2001: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Ziprasidone was first used.

Who makes Ziprasidone?

▾
42 companies list Ziprasidone products in the FDA's NDC Directory, including Remedyrepack Inc., Roerig, Golden State Medical Supply, Inc.. That count includes repackagers and distributors as well as manufacturers, so fewer companies actually make it; the label on your bottle names the one that supplied yours.

Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

More about Ziprasidone on HelloPharmacist

📊Ziprasidone supplement interactions188 checked — ranked by severity 🌿Drug & Supplement CheckerZiprasidone vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Ziprasidone NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
Detailed data & references for Ziprasidone Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

Ziprasidone forms and strengths (how it comes)

Ziprasidone is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Capsule

By mouth
Brands Geodon
How this form is used
What it may be used for
  • Geodon capsules treat schizophrenia in adults.
  • Geodon capsules treat manic or mixed episodes of bipolar I disorder alone and maintenance of bipolar I disorder with lithium or valproate.
  • Ziprasidone hydrochloride capsules are used for schizophrenia and bipolar I disorder in adults.
Important instructions
  • Geodon capsules are taken by mouth with food.
  • Geodon capsules should be swallowed whole, not opened, crushed or chewed.
  • Ziprasidone hydrochloride capsules are taken with food and swallowed whole.
Available strengths 4 strengths
20 mg 40 mg 60 mg 80 mg
316 FDA-listed product records ⓘ

Injection

Into a muscle
Brands Geodon Ziprasidone Mesylate 20 mg/mL
How this form is used
What it may be used for
  • Geodon for injection is used for acute agitation in adults with schizophrenia.
  • Ziprasidone mesylate for injection is used for acute agitation in adults with schizophrenia who need intramuscular medicine for rapid control.
Important instructions
  • Ziprasidone mesylate for injection is given into a muscle only, never into a vein.
  • Ziprasidone mesylate for injection vials are mixed with sterile water before use.
  • Ziprasidone mesylate for injection has not been studied for more than three days in a row; oral capsules should replace it as soon as possible if long-term treatment is needed.
  • Geodon injection is not recommended together with oral ziprasidone.
Available strengths 1 strength
20 mg/mL
24 FDA-listed product records ⓘ

Ziprasidone on the U.S. market: products, makers and brands

How Ziprasidone appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

42 companies list 354 Ziprasidone product records with the FDA, mostly as capsule, injection; the earliest marketing or approval year on record is 2001. Brand names on the directory include Geodon, Ziprasidone Mesylate 20 mg/mL; the rest are generics.

2
Dose forms ⓘ
42
Labelers (makers, repackagers, distributors)
5
Brand names
354
FDA-listed product records ⓘ
2001
Earliest FDA record ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Powder (14) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Remedyrepack Inc.13%
Roerig9%
Golden State Medical Supply, Inc.6%
Aurobindo Pharma Limited5%
Bryant Ranch Prepack5%
Major Pharmaceuticals5%
Other makers57%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

How widely Ziprasidone is used (Medicaid data)

A general measure of how commonly Ziprasidone is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Ziprasidone is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

438,206
Medicaid prescriptions filled (Q1–Q4 2025)
$10.9M gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Ziprasidone prescribed? Of the 1,601 medications we measure, Ziprasidone ranks #278 by Medicaid prescriptions — more than 83% of them.

Where Ziprasidone ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #278 of 1,601
#273 Penicillin V Potassium 451,965 Rx #274 Viloxazine 451,086 Rx #275 Omega-3-Acid Ethyl Est... 450,937 Rx #276 Fentanyl 440,395 Rx #277 Formoterol / Mometason... 440,187 Rx #278 Ziprasidone 438,206 Rx #279 Ciclopirox Topical 437,507 Rx #280 Diltiazem 435,096 Rx #281 Warfarin 433,961 Rx #282 Acetaminophen, Butalbi... 425,589 Rx #283 Varenicline 417,684 Rx

Utilization by Ziprasidone product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

The 40 mg oral capsule is the most-dispensed Ziprasidone product — about 27% of these Medicaid prescriptions.

ziprasidone 40 MG Oral Capsule Most dispensed

120,498 Medicaid prescriptions (Q1–Q4 2025) 27% of Ziprasidone prescriptions shown $2.7M gross reimbursement (before rebates) ≈ $23 per prescription (gross)

Summed across the 7 of 77 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313776

ziprasidone 80 MG Oral Capsule

119,216 Medicaid prescriptions (Q1–Q4 2025) 27% of Ziprasidone prescriptions shown $3.3M gross reimbursement (before rebates) ≈ $28 per prescription (gross)

Summed across the 7 of 85 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313778

ziprasidone 20 MG Oral Capsule

106,654 Medicaid prescriptions (Q1–Q4 2025) 24% of Ziprasidone prescriptions shown $2.4M gross reimbursement (before rebates) ≈ $22 per prescription (gross)

Summed across the 8 of 56 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 314286

ziprasidone 60 MG Oral Capsule

89,114 Medicaid prescriptions (Q1–Q4 2025) 20% of Ziprasidone prescriptions shown $2.3M gross reimbursement (before rebates) ≈ $26 per prescription (gross)

Summed across the 7 of 72 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 313777

ziprasidone 20 MG Injection

2,724 Medicaid prescriptions (Q1–Q4 2025) <1% of Ziprasidone prescriptions shown $130,980 gross reimbursement (before rebates) ≈ $48 per prescription (gross)

Summed across the 6 of 23 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 351223

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Ziprasidone, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 35 of 313 listed Ziprasidone NDCs with Medicaid activity.

Compare Ziprasidone products

A representative set of FDA-listed product records for Ziprasidone — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 200 of 354 products — FDA National Drug Code Directory. See every product, package size and price: browse all 354 Ziprasidone NDCs →

Ziprasidone recall history

A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

The FDA’s enforcement reports list 2 Ziprasidone recalls since July 2021. None of them is still listed as ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.

Class I May 31, 2023 · Terminated · The Harvard Drug Group LLC dba Major Pharmaceuticals and Rugby Laboratories
Labeling: Label Mix-up: Unit Dose cartons labeled as Ziprasidone Hydrochloride Capsules, 20 mg were found to contain blister packages labeled as and containing Dronabinol Capsules, USP, 2.5 mg.
  • ZIPRASIDONE HYDROCHLORIDE CAPSULES 20 mg, Unit Dose Carton 40 Capsules, Rx only, Mfd. By: Dr. Reddy's Laboratories Limited Bachupally-500 090 India, Distributed by: Major Pharmaceuticals Livonia, MI… Lots: Lot: T04769 Exp. 2024/12 FDA record D-0893-2023 →
Class II Apr 13, 2022 · Terminated · Mckesson Medical-Surgical Inc. Corporate Office
cGMP deviations: Temperature abuse
  • Geodon for injection (ziprasidone mesylate), 20 mg/mL, 1 mL single dose vial, Rx only, MFG: Viatris, NDC 0049-3920-83 Lots: McKesson Medical-Surgical (MMS) is not able to identify the particular lot number received by a particular consignee for the recalled prescription products. Each letter includes the date it was distributed to customers and the dates that i… FDA record D-1112-2022 →

Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Ziprasidone RxCUI 115698 2 dose forms · 5 strengths
  1. Dose form (SCDF) Injection RxCUI 1727275 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 351223
  2. Dose form (SCDF) Oral Capsule RxCUI 374649 In current FDA listings
    Clinical drug / strength (SCD) 20 MG RxCUI 314286 40 MG RxCUI 313776 60 MG RxCUI 313777 80 MG RxCUI 313778

Look up RxCUI 115698 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

Ziprasidone brand names

Ziprasidone is sold under 2 brand names in the FDA directory — Geodon, Ziprasidone Mesylate 20 mg/mL. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

Geodon Ziprasidone Mesylate 20 mg/mL

Who makes Ziprasidone: manufacturers and labelers

40 companies list Ziprasidone products with the FDA. By number of product records, the largest are Remedyrepack Inc., Roerig, Golden State Medical Supply, Inc.. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

Remedyrepack Inc. 47 Roerig 33 Golden State Medical Supply, Inc. 20 Aurobindo Pharma Limited 18 Bryant Ranch Prepack 18 Major Pharmaceuticals 16 Apotex Corp. 16 Pfizer Ireland Pharmaceuticals Unlimited Company 16 Greenstone LLC 12 NorthStar Rx LLC 12 Dr. Reddy's Laboratories Limited 12 BluePoint Laboratories 12 AvPAK 12 A-S Medication Solutions 11 Viatris Specialty LLC 10 Zydus Lifesciences Limited 9 McKesson Corporation dba SKY Packaging 8 Viona Pharmaceuticals Inc 8 Macleods Pharmaceuticals Limited 8 American Health Packaging 8 NuCare Pharmaceuticals,Inc. 7 Lupin Pharmaceuticals, Inc. 4 Fosun Pharma USA Inc. 4 Sandoz Inc 4

…and 16 more on the FDA NDC directory.

Ziprasidone drug class (RxNorm)

Ziprasidone belongs to the Atypical Antipsychotic class.

Pharmacologic class Atypical Antipsychotic
Drug family (ATC) Indole derivatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

Sources for this Ziprasidone page

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Jan 13, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Ziprasidone.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Ziprasidone after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
39
NDC products indexed
354
Distinct labelers/manufacturers represented
42
Linked representative label ⓘ
Roerig
Linked label effective
Jan 13, 2025
Composite sections available
24
Linked SPL Set ID
8326928a-2cb6-4f7f-9712-03a425a14c37
Linked SPL Document ID
c717f8ab-3351-4caa-b1fa-86c2fa415189
Open the linked representative label on DailyMed ↗

How this page is built

HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Roerig is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →