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Tusnel Pediatric Dextromethorphan, Guiafenesin, Pseudoephedrine HCl 5 mg/5mL; 50 mg/5mL; 15 mg/5mL Liquid, 473 mL — NDC 54859-0544-16 package photo

Tusnel Pediatric Dextromethorphan, Guiafenesin, Pseudoephedrine HCl 5 mg/5mL; 50 mg/5mL; 15 mg/5mL Liquid, 473 mL

by Llorens Pharmaceutical International Division · 473 mL in 1 BOTTLE (54859-544-16)
NDC 54859-0544-16
🏷️ FDA NDC (as labeled) 54859-544-16 billing pads the product segment with a zero
This package
Contains473 mL Cost per mL$0.0551 NADAC Per package$26.06 / 473 ml Pack sizes2 compare ↓
Also comes in: 118 ml 54859-0544-04
OTC On market Non-controlled
🗂️ Data synced Sep 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

🆔 Identity & classification

FDA NDC (as labeled) 54859-544-16
Product NDC 54859-544
11-digit billing NDC 54859054416
NCPDP billing unit ML — per mL (volume)
RxCUI 1098911
UNII 9D2RTI9KYH, 495W7451VQ, 6V9V2RYJ8N
UPC 0054859544161
Application # M012
SPL Set ID 82f447f6-4f1b-4f56-9d7d-ea02adeea88c
Established class (EPC) Expectorant
Physiologic effect Decreased Respiratory Secretion Viscosity; Increased Respiratory Secretions
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2006-01-01
Route ORAL
Dosage form LIQUID
Substance DEXTROMETHORPHAN HYDROBROMIDE; GUAIFENESIN; PSEUDOEPHEDRINE HYDROCHLORIDE
GPI-14 43997303320915
GPI class Tusnel Pediatric
GCN Seq No 033849
GCN 53357
HICL code 000222
Ingredient (HICL) Guaifenesin/Dm/Pseudoephedrine
HIC1 code B
Therapeutic class — broad (HIC1) Respiratory System
HIC2 code B4
Therapeutic class — intermediate (HIC2) Drugs Affecting The Trachea And Bronchi (Contin.1)
HIC3 code B4R
Therapeutic class — specific (HIC3) Non-Opioid Antitussive-Decongestant-Expectorant
AHFS code 12:12.12.00
AHFS class Alpha- And Beta-Adrenergic Agonists
FDB label name TUSNEL PED 5-50-15 MG/5 ML LIQ
FDB brand name Tusnel Pediatric
Legend status O — Over-the-counter (OTC) drug or device
Why two NDCs? The FDA registers this code as 54859-544-16 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 54859-0544-16. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

🏷️ RxNorm drug class

This medicine belongs to the Uncompetitive N-methyl-D-aspartate Receptor Antagonist class.

Pharmacologic class Uncompetitive N-methyl-D-aspartate Receptor Antagonist, Sigma-1 Agonist
Drug family (ATC) Other antidepressants, Opium alkaloids and derivatives
How it works Uncompetitive NMDA Receptor Antagonists, Sigma-1 Receptor Agonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

🏭 Manufacturer & labeler

LabelerLlorens Pharmaceutical International Division
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code54859
First marketedJan 2006
Product typeHuman Otc Drug
Portfolio10 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

🩺 Clinical

Label name TUSNEL PED 5-50-15 MG/5 ML LIQ Ingredient Guaifenesin/Dm/Pseudoephedrine
📖 About the active ingredient MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.

Dextromethorphan is used to temporarily relieve cough caused by the common cold, the flu, or other conditions. Dextromethorphan will relieve a cough but will not treat the cause of the cough or speed recovery. Dextromethorphan is in a class of medications called antitussives. It works by decreasing activity in the part of the brain that causes coughing.

Read the full MedlinePlus article ↗
🧪 What is this product?

Tusnel Pediatric is an over-the-counter liquid medicine taken by mouth that combines three active ingredients commonly used to relieve cold and cough symptoms in children. Dextromethorphan is a cough suppressant that works on the cough reflex in the brain. Guaifenesin is an expectorant that helps thin mucus to make coughs more productive. Pseudoephedrine is a decongestant that reduces nasal congestion and swelling in the airways.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

🧪 Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 2968PHW8QP
    A weak organic acid derived from citrus fruits or made through fermentation. It works as a buffer to control pH, a preservative to extend shelf life, and a flavoring agent in medications.
  • UNII A2I8C7HI9T
    Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII Z8IX2SC1OH
    Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
  • UNII 1Q73Q2JULR
    Sodium citrate is a salt derived from citric acid. It works as a buffer to maintain the medicine's pH level and may also help improve taste or act as a preservative in the formulation.
  • UNII 96K6UQ3ZD4
    Sucralose is a synthetic sweetener made from sugar. It's added to medicines to improve taste without adding calories, helping make bitter or unpleasant-tasting drugs easier to take.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

7 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesInactive ingredients astificial and natural flavor, citric acid, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate, and sucralos

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

💲 Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.055 $26.06 / 473 ml
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Apr 2026 May 2026 Jul 2026 Sep 2026 $0.055 $0.053
▲ Up 4% over the last 6 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

🔁 Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Tusnel Pediatric 5 mg/5mL; 50 mg/5mL; 15 mg/5mLthis 54859-0544-16 Llorens 473 ml $0.055 — Availability likely —
Actinel Pediatric 5 mg/5mL; 50 mg/5mL; 15 mg/5mL 63102-0102-16 ACTIPHARMA, 474 ml — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

⏳ Availability & generic status

🏛️
2006
On the market since
Jan 2006
📍
2026
Currently FDA-listed
20 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

🔬 Reported adverse events (FAERS)

Read carefully: FAERS reports are voluntary and unverified. Counts are not incidence, do not establish causation, are subject to reporting bias, and cannot be used to compare one drug to another. Shown for signal context only. Reports for Tusnel Pediatric (this brand).

Top reported reactions

Headache2
Abdominal Pain Upper1
Administration Site Pain1
Asphyxia1
Cough1
Diarrhoea1
Discomfort1

Age at onset

Elderly1

Reporter sex

4 reports
Male · 50%
Female · 50%

Serious outcomes

Hospitalization2
Reports over time (by year) — tap or hover for the count & year
2020 2022 2024 2026 1 0
Most recent year is provisional (FAERS lags ~3 months).
Where does this data come from?
Adverse-event reports from the FDA Adverse Event Reporting System (FAERS) via openFDA. FAERS reports are voluntary and unverified — counts are not incidence and don’t establish causation.

📦 Packaging — all sizes for this product

Package NDCDescription Per unit Per pack Marketing startStatus
54859-0544-04 118 mL in 1 BOTTLE (54859-544-04) — — 2006-01-01 Active
54859-0544-16 You're viewing this 473 mL in 1 BOTTLE (54859-544-16) $0.0551 / mL $26.05 2006-01-01 Active

You're viewing the largest of 2 pack sizes for this product.

Pack size FAQ

What quantity is in NDC 54859-0544-16?
NDC 54859-0544-16 contains 473 mL — 473 ml in 1 bottle.
What is the difference between NDC 54859-0544-16 and NDC 54859-0544-04?
Both are Tusnel Pediatric Dextromethorphan, Guiafenesin, Pseudoephedrine HCl 5 mg/5mL; 50 mg/5mL; 15 mg/5mL Liquid — the drug itself is identical. NDC 54859-0544-16 is the 473 mL package, while NDC 54859-0544-04 is the 118 ml package.
What NDC number is used to bill for this package of Tusnel Pediatric Dextromethorphan, Guiafenesin, Pseudoephedrine HCl 5 mg/5mL; 50 mg/5mL; 15 mg/5mL Liquid?
Bill NDC 54859-0544-16 — the 11-digit billing format is 54859054416. Pharmacy and medical claims use the 11-digit form; the FDA label may print a shorter form of the same code.

Prices are the latest CMS NADAC pharmacy acquisition cost per NDC; per-pack figures are per-unit × pack quantity, shown only when the pack is denominated in the same measure NADAC prices.

📄 FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose
🎯 Indications and Usage 32 words ▾

Uses helps loosen phlegm (mucus) and thin bronchial secretions to make coughs more productive temporarily relieves these symptoms occurring with a cold: nasal congestions, cough due to minor throat and bronchial irritation.

⏱️ Dosage and Administration 80 words ▾

Directions Do not exceed more than 4 doses in any 24-hour period or as directed by a doctor. Age Weight Dose Children 6 to under 12 years of age 45 lbs to under 95 lbs Take 2 teaspoonfuls (10 mL) every 4 to 6 hours Children 2 to under 6 years of age 25 lbs to under 45 lbs Take 1 teaspoonful (5mL) every 4 to 6 hours Children under 2 years of age Under 25 lbs ask a doctor

⚠️ Warnings 56 words ▾

Warnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

🧪 Active Ingredient 14 words ▾

Active Ingredients(in each 5 ml tsp.) Purpose Dextromethorphan HBr........5mg..................................................Cough Suppressant Guaifenesin........................50mg................................................Expectorant Pseudoephedrine HCl..........15mg..................................................Nasal Decongestant

🧪 Inactive Ingredients 18 words ▾

Inactive ingredients astificial and natural flavor, citric acid, methylparaben, propylene glycol, propylparaben, purified water, sodium citrate, and sucralos

🎯 Purpose 6 words ▾

Purpose Cough Suppressant Expectorant Nasal Decongestant

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗
← 54859-0517-16 · Llorens 54859-0603-02 · Llorens →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.