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Itch Relief Diphenhydramine Hydrochloride, Zinc Acetate 2 g/100g; .1 g/100g Cream — NDC 59779-708-64 (Billing 59779-0708-64)

by CVS Pharmacy · 1 TUBE in 1 CARTON / 28 g in 1 TUBE

This is a package of Itch Relief Diphenhydramine Hydrochloride, Zinc Acetate 2 g/100g; .1 g/100g Cream from CVS Pharmacy, marketed since Jun 2005 and currently FDA-listed. It is this product's only package size.

NDC 59779-0708-64
🏷️ FDA NDC (as labeled) 59779-708-64 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Sep 3, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 59779-708-64
Product NDC 59779-708
11-digit billing NDC 59779070864
RxCUI 1087026
UNII TC2D6JAD40, FM5526K07A
Application # M017
SPL Set ID 0e988da1-1904-431d-a152-bdb2aacc8e16
Established class (EPC) Copper Absorption Inhibitor; Histamine-1 Receptor Antagonist
Mechanism of action Histamine H1 Receptor Antagonists
Physiologic effect Decreased Copper Ion Absorption
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2005-06-08
Route TOPICAL
Dosage form CREAM
Substance DIPHENHYDRAMINE HYDROCHLORIDE; ZINC ACETATE
Quick answers
  • RxCUI (RxNorm): 1087026
Why two NDCs? The FDA registers this code as 59779-708-64 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 59779-0708-64. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Histamine-1 Receptor Antagonist class.

Pharmacologic class Histamine-1 Receptor Antagonist
Drug family (ATC) Propionic acid derivatives, Antihistamines for topical use, Aminoalkyl ethers
How it works Histamine H1 Receptor Antagonists
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

🧪 What is this product?

This is a topical cream marketed as an over-the-counter monograph product for itch relief. It contains diphenhydramine hydrochloride, an antihistamine that is commonly used to reduce itching and minor skin irritation when applied to the skin, and zinc acetate, an astringent ingredient typically used to help soothe and protect irritated skin. The product is applied directly to affected areas of the skin.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
1
Nutrient depletion considerations

Diphenhydramine Hydrochloride, Naproxen Sodium may be associated with lower levels of 1 nutrient — worth a chat with your pharmacist, not a cause for alarm.

🧪 Full Diphenhydramine Hydrochloride, Naproxen Sodium nutrient depletion report →
An association is not a deficiency. Educational only — don't start or stop anything without professional guidance.
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer gPer package
Retail pharmacies payNADAC · weekly Not in the retail survey — common for institutional, discontinued, or low-volume packs.
Medicaid paysCMS SDUD · 12 mo No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data.
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
ℹ️
No price is published for this exact package yet. CMS surveys NADAC per package size, so a different pack of the same drug often has one.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
59779-0708-64 You're viewing this Main listing 1 TUBE in 1 CARTON / 28 g in 1 TUBE 2005-06-08 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
good sense itch relief 2 g/100g; .1 g/100g 00113-0622-64 L. 1 tube $0.058 — Availability likely —
Banophen 2 g/100g; .1 g/100g 00904-5354-31 Major 1 tube $0.058 — Availability likely —
diphenhydramine hcl and zinc acetate 2 g/100g; .1 g/100g 45802-0358-03 Padagis 1 tube $0.058 — Availability likely —
GNP Extra Strength Anti-Itch Cream .1 g/100g; 2 g/100g 46122-0804-36 Amerisource 1 tube $0.058 — Availability likely —
leader anti itch 2 g/100g; .1 g/100g 70000-0388-01 Cardinal 1 tube $0.058 — Availability likely —
foster and thrive anti itch cream 2 g/100g; .1 g/100g 70677-1289-01 Strategic 1 tube $0.058 — Availability likely —
Anti-Itch 20 mg/g; 1 mg/g 24385-0210-03 Amerisource 1 tube $0.130 — Discontinued —
Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 70677-1213-01 STRATEGIC 1 tube $0.130 — FDA listed —
Walgreens Anti Itch Cream 20 mg/g; 1 mg/g 00363-2315-28 Walgreens 1 tube — — FDA listed —
Dr. Sheffield Anti Itch Cream 20 mg/g; 1 mg/g 11527-0069-04 Sheffield 1 tube — — FDA listed —
Anti-itch 20 mg/g; 1 mg/g 11673-0895-28 Target 1 tube — — FDA listed —
Rite Aid Extra Strength Itch Stopping 1 mg/g; 20 mg/g 11822-6614-01 Rite 1 tube — — FDA listed —
signature care itch relief 2 g/100g; .1 g/100g 21130-0154-64 Safeway 1 tube — — FDA listed —
anti itch 2 g/100g; .1 g/100g 30142-0582-64 Kroger 1 tube — — FDA listed —
Shopko Anti-Itch 20 mg/g; 1 mg/g 37012-0089-02 Shopko 1 tube — — FDA listed —
itch relief 2 g/100g; .1 g/100g 37808-0622-64 H 1 tube — — FDA listed —
Anti-Itch Cream 1 mg/g; 20 mg/g 41226-0888-02 Kroger 1 tube — — FDA listed —
Anti Itch 2 g/100g; .1 g/100g 41250-0622-64 Meijer 1 tube — — FDA listed —
Equate Anti Itch 2 g/100g; .1 g/100g 49035-0622-64 Wal-Mart 1 tube — — FDA listed —
Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 51672-2089-02 Sun 1 tube — — FDA listed —
CAREALL Anti-Itch 20 mg/g; 1 mg/g 51824-0088-01 New 35 g — — FDA listed —
Extra Strength Itch Stopping 20 mg/g; 1 mg/g 52000-0071-02 Universal 1 tube — — FDA listed —
Discount Drug Mart Extra Strength Itch Stopping 20 mg/g; 1 mg/g 53943-0258-01 Discount 1 tube — — FDA listed —
Family Wellness 2 g/100g; .1 g/100g 55621-0007-01 Zhejiang 1 tube — — FDA listed —
ItchZap 20 mg/g; 1 mg/g 57237-0352-28 Rising 1 tube — — FDA listed —
Itch Relief 2 g/100g; .1 g/100gthis 59779-0708-64 CVS 1 tube — — FDA listed —
Itch Relief Cream 2 g/100g; .1 g/100g 68016-0163-01 Pharmacy 1 tube — — FDA listed —
Anti-Itch Cream 2 g/100g; .1 g/100g 69396-0025-05 Trifecta 1 tube — — FDA listed —
Itch stopping Cream 2 g/100g; .1 g/100g 69396-0150-01 Trifecta 1 tube — — FDA listed —
itch relief 1 mg/g; 20 mg/g 69452-0449-37 Bionpharma 1 tube — — FDA listed —
Family Wellness 2 g/100g; .1 g/100g 69571-0005-02 FRONT 1 tube — — FDA listed —
CVS Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69842-0321-28 CVS 1 tube — — FDA listed —
Benadryl Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69968-0223-01 Kenvue 1 tube — — FDA listed —
TheraCare 2% Diphenhydramine Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0014-01 Veridian 1 tube — — FDA listed —
Caring Mill Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0055-01 Veridian 1 tube — — FDA listed —
Anti-Itch Cream 2 g/100g; .1 g/100g 83324-0039-01 Chain 1 tube — — FDA listed —
Savvy Itch Stopping 2 g/100g; .1 g/100g 83650-0102-01 Savvy 35.4 g — — FDA listed —
topcare anti itch 2 g/100g; .1 g/100g 36800-0622-64 Topco 1 tube — — FDA listed —
Itch Stopping 2 g/100g; .1 g/100g 42507-0622-64 HyVee 1 tube — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2005
On the market since
Jun 2005
📍
2026
Currently FDA-listed
21 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

Loading inactive ingredients from the official FDA label in the background. No external source is being called by this page request.
Where does this data come from?
Source: official FDA Structured Product Labeling (SPL) via DailyMed and the openFDA label index. Structured IACT rows and label-wide narrative are kept separate; availability and product-level specificity depend on the submitted label.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerCVS Pharmacy
FDA applicationM017 (OTC MONOGRAPH DRUG)
Labeler code59779
First marketedJun 2005
Product typeHuman Otc Drug
Portfolio550 products on file
The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 📦 Storage and Handling 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Do Not Use 📄 Ask a Doctor Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 51 words ▾

Uses • temporarily relieves pain and itching associated with: • insect bites • minor burns • sunburn • minor skin irritations • minor cuts • scrapes • rashes due to poison ivy, poison oak and poison sumac • dries the oozing and weeping of poison ivy, poison oak and poison sumac

⏱️ Dosage and Administration 40 words ▾

Directions • do not use more than directed • adults and children 2 years of age and older: apply to affected area no more than 3 to 4 times daily • children under 2 years of age: ask a doctor

⚠️ Warnings 103 words ▾

Warnings For external use only Do not use • on large areas of the body • with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use • on chicken pox • on measles When using this product • avoid contact with the eyes Stop use and ask a doctor if • condition worsens or does not improve within 7 days • symptoms persist for more than 7 days or clear up and occur again within a few days Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📦 Storage and Handling 7 words ▾

Other information • store at 20°-25°C (68°-77°F)

🧪 Active Ingredient 8 words ▾

Active ingredients Diphenhydramine hydrochloride 2% Zinc acetate 0.1%

🧪 Inactive Ingredients 16 words ▾

Inactive ingredients cetyl alcohol, diazolidinyl urea, methylparaben, PEG-2 stearate, PEG-20 stearate, propylene glycol, propylparaben, purified water

🎯 Purpose 5 words ▾

Purpose Topical analgesic Skin protectant

📄 Do Not Use 22 words ▾

Do not use • on large areas of the body • with any other product containing diphenhydramine, even one taken by mouth

📄 Ask a Doctor Before Use If 12 words ▾

Ask a doctor before use • on chicken pox • on measles

📄 When Using This Product 10 words ▾

When using this product • avoid contact with the eyes

📄 Stop Use and Ask a Doctor If 35 words ▾

Stop use and ask a doctor if • condition worsens or does not improve within 7 days • symptoms persist for more than 7 days or clear up and occur again within a few days

📄 Keep Out of Reach of Children 19 words ▾

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

📄 Questions or Comments 4 words ▾

Questions or comments? 1-800-719-9260

📄 Package Label / Principal Display Panel 61 words ▾

Principal Display Panel CVS TM Extra Strength ITCH RELIEF CREAM Diphenhydramine Hydrochloride 2% | Zinc Acetate 0.1% Compare to Extra Strength Benadryl ® Itch Stopping Cream active ingredients NET WT 1 OZ (28 g) Temporary Relief of Itch & Pain Due to: Insect bites, Rashes from poison ivy, poison oak & poison sumac, Minor skin irritations Topical Analgesic Skin Protectant itch-relief

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

About this NDC listing & data coverage

Over-the-counter (OTC) product
What data is (and isn’t) available for this NDC — tap to expand
NDC identity (package / product / labeler codes) ✓ Available
Labeler ✓ Available
Product & package description ✓ Available
Marketing category & status ✓ Available
Active ingredient / dosage form / route ✓ Available
FDA label (SPL via DailyMed) ✓ Available
Package photos — Not published for this NDC No photo available yet for this listing.
Inactive ingredients (structured) — Not published for this NDC The labeler did not submit a structured excipient list, or no SPL is available.
NADAC pharmacy acquisition price (CMS) — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey.
Orange Book / therapeutic-equivalence data — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope.
HCPCS J-code billing crosswalk — Not published for this NDC Most self-administered / retail products have no J-code — that is normal.
Medicaid utilization (CMS SDUD) — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold.
“Not published” reflects what the public FDA / CMS / NLM sources provide for this exact package code — it is a property of the data feeds, not a judgment about the product.

Questions about this listing

Is this NDC FDA-approved?
An NDC listing does not by itself establish FDA approval — the NDC Directory records that a product is listed with FDA, not that it was reviewed and approved. This listing's marketing category is "Otc Monograph Drug". Products approved under an application carry an NDA, ANDA, or BLA number.
Why is there no price listed?
The pricing shown on our NDC pages comes from CMS NADAC, a voluntary survey of retail community pharmacy invoices. CMS does not publish a NADAC for every NDC — packages outside the retail survey (institutional and hospital products, bulk packages, discontinued items, and many OTC items) may never receive one. A missing price reflects the survey's scope, not this product's actual cost, and does not mean the product is free or unavailable.
Is the NDC printed on the package the same as the 11-digit billing NDC?
Yes, they identify this exact package in different formats. The form printed on the packaging and shown on DailyMed is the one the FDA registered. Insurance claims use a fixed 11-digit 5-4-2 format, so the short segment is padded with a leading zero and the dashes are dropped. The Identity section at the top of this page lists each form of this code.
Is this package still being marketed?
Yes, per the latest FDA NDC Directory data on this page: this package is listed as actively marketed, with no marketing end date reported by CVS Pharmacy. Listing status can change — the directory data on this page refreshes weekly.
Who lists this product with the FDA?
CVS Pharmacy is the labeler of record for this NDC — the company under whose FDA-assigned code the package is listed. The labeler may be the manufacturer itself or a distributor marketing the product under its own code.
Do I need a prescription for this product?
This NDC is listed with FDA as an over-the-counter product, so it does not require a prescription. Follow the package directions, and ask your pharmacist if you are unsure whether it is right for you.
This page identifies an FDA-listed package (the NDC) and reports public regulatory and pricing data about the listing. It is reference information, not a medical recommendation — talk to your pharmacist or prescriber about your own medication.
Where does this data come from?
Listing facts (marketing category, packager status, marketing dates) from the FDA openFDA NDC Directory; label availability from DailyMed; pricing coverage from CMS NADAC; equivalence scope from the FDA Orange Book.
← 59779-0703-52 · CVS 59779-0709-21 · CVS →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.