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EndaCof DM Brompheniramine Maleate, Dextromethorphan Hydrobromide and Phenylephrine Hydrochloride 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mL Liquid, 473 mL — NDC 68047-0143-16 package photo
Label image from the product's FDA listing (DailyMed) — may show a different pack size or an older label revision.

EndaCof DM Brompheniramine Maleate, Dextromethorphan Hydrobromide and Phenylephrine Hydrochloride 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mL Liquid, 473 mL — NDC 68047-143-16 (Billing 68047-0143-16)

by Larken Laboratories, Inc. · 473 mL in 1 BOTTLE

This is a package of 473 mL of EndaCof DM Brompheniramine Maleate, Dextromethorphan Hydrobromide and Phenylephrine Hydrochloride 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mL Liquid from Larken Laboratories, Inc., marketed since Mar 2012 and currently FDA-listed; retail pharmacies pay about $0.0512 per mL (NADAC). It is this product's only package size.

NDC 68047-0143-16
🏷️ FDA NDC (as labeled) 68047-143-16 billing pads the product segment with a zero
OTC On market Non-controlled ⇄ Compare with another NDC
🗂️ FDA directory synced Oct 1, 2026 · this listing last changed Jul 24, 2026 · sources: openFDA · FDA label (DailyMed) · FDA Orange & Purple Book · First Databank · CMS NADAC, ASP, Medicare & Medicaid · RxNorm
📋 All sources & update times →

This page is curated, coded, and maintained by

Compiled from public FDA, CMS, DailyMed, NADAC, and related drug data sources. Editorial policy

NDC database record

One package, one record: these facts belong to NDC 68047-143-16 alone.

Record
FDA NDC Directory package listing · Human OTC drug
Code segments
68047 labeler · 143 product · 16 package
Package marketed since
Mar 30, 2012
Sample package
No — commercial package
Listing certified through
Dec 31, 2026
Billing quantity
473 mL per package
Barcode (UPC)
0368047143167
Medicaid fills, this package
18,287 prescriptions in the last four reported quarters
FDA record last changed
Jul 24, 2026

Identity & classification

Regulatory identifiers FDA, NLM and CMS codes for this package

FDA NDC (as labeled) 68047-143-16
Product NDC 68047-143
11-digit billing NDC 68047014316
NCPDP billing unit ML — per mL (volume)
RxCUI 1090463
UNII IXA7C9ZN03, 9D2RTI9KYH, 04JA59TNSJ
UPC 0368047143167
Application # M012
SPL Set ID c68ea55a-8b9a-4a70-8b5c-1a2736651813
Established class (EPC) Sigma-1 Agonist; Uncompetitive N-methyl-D-aspartate Receptor Antagonist; alpha-1 Adrenergic Agonist
Mechanism of action Adrenergic alpha1-Agonists; Sigma-1 Receptor Agonists; Uncompetitive NMDA Receptor Antagonists
DEA schedule Non-controlled
Marketing category OTC MONOGRAPH DRUG
Marketing status On market
FDA listing status Listed (active directory)
Marketing start 2012-03-30
Route ORAL
Dosage form LIQUID
Substance BROMPHENIRAMINE MALEATE; DEXTROMETHORPHAN HYDROBROMIDE; PHENYLEPHRINE HYDROCHLORIDE

Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification

GPI-14 43995803080910
GPI class EndaCof-DM
GCN Seq No 060622
GCN 26808
HICL code 035368
Ingredient (HICL) Brompheniram/Phenylephrine/Dm
HIC1 code B
Therapeutic class — broad (HIC1) Respiratory System
HIC2 code B3
Therapeutic class — intermediate (HIC2) Drugs Affecting Primarily The Trachea And Bronchi
HIC3 code B3R
Therapeutic class — specific (HIC3) Non-Opioid Antitus-1St Gen.antihistamine-Decongest
AHFS code 04:04.20.00
AHFS class Propylamine Derivatives
FDB label name ENDACOF-DM LIQUID
FDB brand name Endacof-Dm
Legend status O — Over-the-counter (OTC) drug or device
Quick answers
  • GSN (GCN sequence number): 060622
  • GCN: 26808
  • GPI-14 (Medi-Span): 43995803080910
  • HICL (First Databank): 035368
  • AHFS class code: 04:04.20.00
  • RxCUI (RxNorm): 1090463
Why two NDCs? The FDA registers this code as 68047-143-16 — a 5-3-2 layout, and that's what's printed on the package and shown on DailyMed. For insurance claims, every NDC is standardized to a uniform 11-digit 5-4-2 format by adding a zero to the product segment → 68047-0143-16. Same drug, same package — only the format differs.
Where does this data come from?
Identifiers from the FDA openFDA NDC Directory and Structured Product Labeling; RxCUI from RxNorm (NLM); GPI from Medi-Span; GCN / HIC / AHFS / legend from First Databank.

RxNorm drug class

This medicine belongs to the Substituted alkylamines class.

Drug family (ATC) Substituted alkylamines
Where does this data come from?
Therapeutic classes from RxNorm RxClass (U.S. National Library of Medicine) — Established Pharmacologic Class (FDA), ATC drug family (WHO) and mechanism of action, matched by this product’s RxCUI.

Clinical

Label name ENDACOF-DM LIQUID Ingredient Brompheniram/Phenylephrine/Dm
📖 About the active ingredient MedlinePlus · NLM
General information about the ingredient itself — the description of this specific product follows below.

Brompheniramine is used to treat allergy and cold symptoms: sneezing runny nose itching of the nose or throat red, itchy, watery eyes Brompheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Read the full MedlinePlus article ↗
🧪 What is this product?

EndaCof DM is an over-the-counter oral liquid cough and cold product containing three active ingredients. Brompheniramine maleate is an antihistamine typically used to reduce allergy-related symptoms and congestion. Dextromethorphan hydrobromide is a cough suppressant commonly found in cold remedies. Phenylephrine hydrochloride is a decongestant typically used to relieve nasal congestion. This product is marketed under FDA's over-the-counter drug monograph rules.

Supplement & herbal interactions

🌿 Drug–supplement interaction checker →
Where does this data come from?
Plain-language summary from MedlinePlus (U.S. National Library of Medicine); supplement & herbal interactions and nutrient depletion data from the Natural Medicines database; our full guide is HelloPharmacist editorial content.

Pricing

A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.

Price systemPer mLPer package
Retail pharmacies payNADAC · weekly $0.051 $24.22 / 473 ml
Medicaid paysCMS SDUD · 12 mo $0.0885 $41.86 / 473 ml
Medicare drug plans payPart D · quarterly No Part D plan price is available for this NDC in our data.
NADAC price history (per mL) — tap or hover for the price & month
Dec 2021 Aug 2022 Feb 2026 Sep 2026 $0.052 $0.037
▲ Up 37% over the last 20 months.
Where does this data come from?
NADAC (National Average Drug Acquisition Cost) is the CMS weekly pharmacy-acquisition-cost survey — what pharmacies pay. ASP (Average Sales Price) is the CMS Medicare Part B drug-payment file, published quarterly. Medicaid pays is computed by us from CMS State Drug Utilization Data (total reimbursed ÷ units, trailing 12 months) — gross of rebates and inclusive of dispensing fees, so it reflects what Medicaid paid, not an acquisition cost. Medicare drug plans pay is the median negotiated point-of-sale unit cost across plans listing this NDC in the CMS quarterly Prescription Drug Plan pricing files, before rebates. The VA pays is the federal contract price (FSS, and the statutory Big 4 ceiling where listed) from the VA National Acquisition Center pharmaceutical price file. All are free public government data; each measures a different payer, so the figures are not directly comparable.

Packaging — all sizes for this product

Package NDCDescription Marketing startMarketing endStatus
68047-0143-16 You're viewing this Main listing 473 mL in 1 BOTTLE 2012-03-30 — Active

Therapeutic equivalents

ProductLabelerPackNADAC/unitTEStatusPrice vs. this
Cold and Cough Relief children 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 70677-0121-01 Strategic 1 bottle $0.017 — Discontinued save 67%
EndaCof DM 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mLthis 68047-0143-16 Larken 473 ml $0.051 — Availability likely —
Good Sense Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 00113-0987-26 L. 1 bottle $0.075 — Availability likely +47%
Rynex DM 2.5 mg/5mL; 1 mg/5mL; 5 mg/5mL 00485-0204-04 Edwards 118 ml $0.075 — Availability likely +47%
dimaphen dm 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 00904-6463-20 Major 1 bottle $0.075 — Availability likely +47%
good neighbor pharmacy cold and cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 24385-0519-26 Amerisource 1 bottle $0.075 — Availability likely +47%
Signature Care Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 21130-0082-26 Safeway 1 bottle — — Discontinued —
Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 30142-0987-26 Kroger 1 bottle — — FDA listed —
cold and cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 37808-0987-26 H 1 bottle — — FDA listed —
equaline childrens cold and cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 41163-0987-26 United 1 bottle — — FDA listed —
CareOne Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 41520-0987-26 American 1 bottle — — Discontinued —
equate childrens cold and cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 49035-0082-34 Wal-Mart 1 bottle — — FDA listed —
Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 51316-0578-03 CVS 1 bottle — — FDA listed —
Childrens Dimetapp Cold And Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 51316-0645-08 CVS 1 bottle — — FDA listed —
Pediacare Childrens Cough and Cold Grape 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 52412-0920-01 RANDOB 1 bottle — — FDA listed —
Childrens Metapp Daytime 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mL 53041-0577-03 Guardian 1 bottle — — FDA listed —
Cold and Cough DM 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 56062-0987-26 Publix 1 bottle — — FDA listed —
dimaphen dm 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 68788-8134-01 Preferred 1 bottle — — FDA listed —
Good Sense Childrens Cold and Cough 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 68788-8331-01 Preferred 1 bottle — — FDA listed —
Dimetapp Cold and Cough 1 mg/5mL; 5 mg/5mL; 2.5 mg/5mL 80070-0310-04 Foundation 1 bottle — — FDA listed —
TARGET CHILDRENs COLD and COUGH 2 mg/10mL; 10 mg/10mL; 5 mg/10mL 82442-0645-04 TARGET 1 bottle — — FDA listed —
About this product: other versions of the same ingredient, strength and form are listed above, least expensive first, with FDA equivalence ratings where available.
Where does this data come from?
Equivalents are other NDCs of the same ingredient, form and route from the openFDA NDC Directory, ranked least-expensive-first by NADAC. Therapeutic-equivalence (AB) ratings come from the FDA Orange Book; biologics use the FDA Purple Book for biosimilar & interchangeable status.

Availability & generic status

🏛️
2012
On the market since
Mar 2012
📍
2026
Currently FDA-listed
14 years listed
🔒
·
No generic listed yet
brand only
ℹ️No FDA-approved generic found

We did not find an FDA-approved generic match for this exact strength, form and route.

Where does this data come from?
Patents and exclusivity from the FDA Orange Book (small-molecule drugs), refreshed from public FDA data. Generic launch timing is an estimate, not a guarantee.

Inactive Ingredients / Excipients

Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.

💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.

  • UNII 8SKN0B0MIM
    Benzoic acid is a naturally occurring organic acid used as a preservative in medicines and foods. It helps prevent bacterial and fungal growth to extend shelf life and maintain product stability.
  • UNII 7FLD91C86K
    Edetate disodium is a chemical compound that binds and removes certain metal ions. In medicines, it acts as a preservative and stabilizer by preventing metals like calcium from interfering with the product's shelf life and consistency.
  • UNII WZB9127XOA
    A synthetic red dye used to color medications and make them easier to identify. It serves as a colorant in tablets, capsules, and liquid formulations.
  • UNII 6DC9Q167V3
    Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
  • UNII SB8ZUX40TY
    Saccharin sodium is an artificial sweetener made from saccharin salt. It's added to medicines to improve taste, especially in liquid formulations for children or bitter drugs.
  • UNII 506T60A25R
    Sorbitol is a natural sugar alcohol derived from glucose. It serves as a sweetener, humectant, and bulking agent in medications to improve taste and help maintain moisture in the product.
  • UNII 059QF0KO0R
    Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.

7 inactive ingredients listed in the exact product block matched to this NDC.

The official label also statesBenzoic acid, edetate disodium, FD&C Red #40, propylene glycol, purified water saccharin sodium, sorbitol solution and strawberry flavoring

Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.

Where does this data come from?
Data sourced from official FDA Structured Product Labeling (SPL) via DailyMed — ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.

Inactive ingredient FAQ

Are inactive ingredients the same for every manufacturer?
No. Inactive ingredients can differ by manufacturer, dosage form, strength, and package / product version.
Why might an inactive ingredient be missing?
Some SPLs do not provide a complete structured inactive-ingredient list, and older or unusual labels may only include the information in narrative text.
Can inactive ingredients matter?
Yes. They can matter for allergies, intolerances, dyes, gluten / lactose concerns, preservatives, and formulation differences — but confirm with a pharmacist or the manufacturer when it’s clinically important.

Manufacturer & labeler

LabelerLarken Laboratories, Inc.
FDA applicationM012 (OTC MONOGRAPH DRUG)
Labeler code68047
First marketedMar 2012
Product typeHuman Otc Drug
Portfolio12 products on file

More NDCs from Larken Laboratories, Inc. labeler code 68047

The labeler markets the product; the application holder owns the FDA approval. They’re often the same company but can differ (e.g. a repackager or an authorized generic). A mailing address / phone appears here when the manufacturer includes it in the product’s FDA label (not all do).
Where does this data come from?
Labeler, application holder and registered establishment from the FDA openFDA NDC Directory and Drugs@FDA; address/contact from the product’s FDA label.

FDA label — Drug Facts FDA SPL

The complete FDA label for this product — the official Drug Facts labeling, verbatim, section by section. Jump with a chip, search within the label, or expand everything.
🎯 Indications and Usage ⏱️ Dosage and Administration ⚠️ Warnings 🧪 Active Ingredient 🧪 Inactive Ingredients 🎯 Purpose 📄 Ask a Doctor Before Use If 📄 Ask a Doctor or Pharmacist Before Use If 📄 When Using This Product 📄 Stop Use and Ask a Doctor If 🤰 If Pregnant or Breast-Feeding 📄 Keep Out of Reach of Children 📄 Questions or Comments 📄 Package Label / Principal Display Panel
🎯 Indications and Usage 54 words ▾

Uses Temporarily relieves these symptoms due to hay fever (allergic rhinitis): cough due to minor throat and bronchial irritation runny nose sneezing itchy, watery eyes itching of the nose or throat temporarily relieves nasal congestion due to the common cold, hay fever or other upper respiratory allergies temporarily restores freer breathing through the nose

⏱️ Dosage and Administration 51 words ▾

Directions Do not exceed 6 doses in a 24-hour period Age Dose Adults and children over 12 years of age: 4 teaspoonsful (20 mL) every 4 hours Children 6 to under 12 years of age: 2 teaspoonsful (10 mL) every 4 hours Children under 6 years of age: Ask your doctor

⚠️ Warnings 65 words ▾

Warnings Do not use to sedate a child or make a child sleepy if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this drug.

🧪 Active Ingredient 22 words ▾

Active Ingredients (In each 5 mL teaspoonful) Brompheniramine Maleate, USP 1 mg Dextromethorphan HBr, USP 5 mg Phenylephrine HCl, USP 2.5 mg

🧪 Inactive Ingredients 20 words ▾

Inactive Ingredients Benzoic acid, edetate disodium, FD&C Red #40, propylene glycol, purified water saccharin sodium, sorbitol solution and strawberry flavoring

🎯 Purpose 13 words ▾

Purpose Brompheniramine Maleate Antihistamine Dextromethorphan HBr Antitussive (cough suppressant) Phenylephrine HCl Nasal decongestant

📄 Ask a Doctor Before Use If 58 words ▾

Ask a doctor before use if you have heart disease high blood pressure thyroid disease diabetes glaucoma trouble urinating due to an enlarged prostate gland a breathing problem such as emphysema or chronic bronchitis a cough that lasts or is chronic such as occurs with smoking, asthma or emphysema a cough that occurs with too much phlegm (mucus)

📄 Ask a Doctor or Pharmacist Before Use If 21 words ▾

Ask a doctor or pharmacist before use if you are taking any other nasal decongestant or stimulant taking sedatives or tranquilizers

📄 When Using This Product 39 words ▾

When using this product Do not exceed recommended dosage. marked drowsiness may occur avoid alcoholic beverages alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery excitability may occur, especially in children

📄 Stop Use and Ask a Doctor If 43 words ▾

Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur. cough or nasal congestion persists for more than 1 week, tends to recur, or is accompanied by a fever, rash or persistent headache. These could be signs of a serious condition.

🤰 If Pregnant or Breast-Feeding 10 words ▾

If pregnant or breast-feeding ask a health professional before use.

📄 Keep Out of Reach of Children 21 words ▾

Keep out of the reach of children In case of overdose, get medical help or contact a Poison Control Center immediately.

📄 Questions or Comments 18 words ▾

Questions or Comments Call 1-601-855-7678 weekdays from 9:00 am to 4:00 pm CST or go to http://www.larkenlabs.com .

📄 Package Label / Principal Display Panel 24 words ▾

Principal Display Panel Figure 1: 16 oz. Bottle Label (Front) figure-01

Principal Display Panel Figure 2: 16 oz. Bottle Label (Drug Facts Continued) figure-02

Source: FDA Structured Product Labeling, mirrored from DailyMed / openFDA. Prefer the government’s original formatting? View this label on DailyMed ↗

Medicaid utilization & spend

📍 This exact package only: Medicaid data is reported per full 11-digit NDC — labeler, product and pack size — so every number here is for this package alone, not the drug overall. Other pack sizes report separately.
💊 Pharmacy benefit only: These are Medicaid outpatient pharmacy claims, billed by NDC. They exclude the medical benefit — clinic- or hospital-administered drugs billed under HCPCS J-codes — so drugs used mostly that way (e.g. Avastin, Lucentis, Keytruda) can look low or missing here. That’s expected, not an error.
📅 Q1 2025 – Q1 2026 · 5 quarters of data
ⓘ The newest quarter is usually incomplete when first published; states restate recent quarters in later CMS releases, so the latest figures typically revise upward. State coverage-policy changes can also shift quarter-to-quarter totals.
Prescriptions last 4 qtrs
18.3K
Units reimbursed last 4 qtrs
3.4M
Gross reimbursed last 4 qtrs
$299.6K
Avg / prescription
$16.38
Avg / unit
$0.0885
Latest quarter Q1 2026
7.4KRx
Medicaid pays / mL
$0.0885
gross reimbursed
vs
NADAC / mL
$0.0512
acquisition cost
=
Spread
+$0.0373
+73% vs cost
What Medicaid paid per mL (before rebates; includes the pharmacy’s dispensing fee) compared with NADAC — the average price pharmacies pay to buy the drug. A positive spread means Medicaid reimbursed more than the purchase price, before manufacturer rebates.
Fee-for-service vs managed care ⓘ
24% FFS 76% MCO
Fee-for-service · 4,305 Rx Managed care · 13,982 Rx
State Medicaid map
Alaska: no data reported AK Maine: no data reported ME Washington: no data reported WA Idaho: no data reported ID Montana: no data reported MT North Dakota: no data reported ND Minnesota: no data reported MN Wisconsin: no data reported WI Michigan: no data reported MI New York: no data reported NY Vermont: no data reported VT New Hampshire: no data reported NH Oregon: no data reported OR Nevada: no data reported NV Wyoming: no data reported WY South Dakota: no data reported SD Iowa: no data reported IA Illinois: no data reported IL Indiana: no data reported IN Ohio: no data reported OH Pennsylvania: no data reported PA New Jersey: 570,964 units · 6,146 per 100k residents NJ Massachusetts: no data reported MA California: 646,967 units · 1,660 per 100k residents CA Utah: no data reported UT Colorado: no data reported CO Nebraska: no data reported NE Missouri: no data reported MO Kentucky: 1,850 units · 40.9 per 100k residents KY West Virginia: 10,106 units · 571 per 100k residents WV Virginia: no data reported VA Maryland: no data reported MD Connecticut: no data reported CT Rhode Island: no data reported RI Arizona: no data reported AZ New Mexico: 7,904 units · 374 per 100k residents NM Kansas: no data reported KS Arkansas: no data reported AR Tennessee: no data reported TN North Carolina: no data reported NC South Carolina: no data reported SC Delaware: no data reported DE Oklahoma: no data reported OK Louisiana: no data reported LA Mississippi: 2,113,281 units · 71,880 per 100k residents MS Alabama: no data reported AL Georgia: 21,639 units · 196 per 100k residents GA D.C.: no data reported DC Hawaii: no data reported HI Texas: 12,457 units · 40.8 per 100k residents TX Florida: no data reported FL
Units reimbursed · per 100k residents
40.871,880
gray = no data reported ⓘ
Colors are per 100,000 residents, so big states don’t automatically dominate. Tap or hover a state for its actual totals.
Tap or hover a state
…for its Medicaid breakdown
🏆 Top states by units · per 100k residents
1 Mississippi 71,880 /100k
2 New Jersey 6,146 /100k
3 California 1,660 /100k
4 West Virginia 571 /100k
5 New Mexico 374 /100k
6 Georgia 196 /100k
7 Kentucky 40.9 /100k
8 Texas 40.8 /100k
National units — by quarter
💵 About the dollar figures: “reimbursed” is what Medicaid paid pharmacies before confidential manufacturer rebates, so the program’s real net cost is lower than these numbers. Fee-for-service and managed-care claims are combined unless split above. Source: CMS State Drug Utilization Data; per-100k rates use 2023 Census population estimates.
← 68047-0129-16 · Larken 68047-0159-16 · Larken →
For educational and professional reference only — not medical advice. Pricing reflects published NADAC and CMS ASP (free public data) and may differ from your acquisition cost; always verify before billing or dispensing.