Anti-Itch Cream Diphenhydramine hydrochloride 2%, zinc acetate 0.1% 2 g/100g; .1 g/100g Cream — NDC 69396-025-05 (Billing 69396-0025-05)
This is a package of Anti-Itch Cream Diphenhydramine hydrochloride 2%, zinc acetate 0.1% 2 g/100g; .1 g/100g Cream from Trifecta Pharmaceuticals USA, LLC., marketed since Dec 2016 and currently FDA-listed. It is the main listing for this product, which comes in 2 package sizes.
Identity & classification
Regulatory identifiers FDA, NLM and CMS codes for this package
Drug-database identifiers Medi-Span GPI and First Databank GCN / HICL / AHFS classification
- GSN (GCN sequence number): 024972
- GCN: 67334
- GPI-14 (Medi-Span): 90209902083735
- HICL (First Databank): 009759
- AHFS class code: 84:08.00.00
- RxCUI (RxNorm): 1087026
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
- RxNorm (NLM RxNav) · catalog refreshed Oct 1, 2026
- Medi-Span GPI (licensed)
- First Databank (licensed) · refreshed Oct 1, 2026
RxNorm drug class
This medicine belongs to the Histamine-1 Receptor Antagonist class.
Where does this data come from?
- RxClass (NLM) · catalog refreshed Oct 1, 2026
Clinical
Diphenhydramine is used to treat allergy and cold symptoms: sneezing runny nose red, itchy, watery eyes itching of the nose or throat Diphenhydramine is also used to treat insomnia (difficulty falling asleep or staying asleep) in adults, but should not be used to make a child sleepy. Diphenhydramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms. Diphenhydramine is also available in combination with other medications. This monograph only includes information about the use of diphenh...
Read the full MedlinePlus article ↗This is an over-the-counter topical cream marketed under FDA's monograph rules for itch relief products. It contains diphenhydramine hydrochloride, an antihistamine commonly used to reduce itching and minor skin irritation, and zinc acetate, which is typically included for its mild astringent and skin-soothing properties. The cream is applied directly to the affected skin area and is intended for temporary relief of minor itching associated with common skin conditions.
Patient education
Supplement & herbal interactions
Where does this data come from?
- MedlinePlus (NLM) · refreshed Oct 1, 2026
- FDA label on DailyMed · label index refreshed Oct 1, 2026
Ask a licensed pharmacist directly — free, answered by our team.
Pricing
A drug doesn't have one price. Each row is a different public payment system, and none is what you'd pay at the counter — that depends on your insurance. The ⓘ on each row explains what it measures.
| Price system | Per g | Per package |
|---|---|---|
| Retail pharmacies payNADAC · weekly | Not in the retail survey — common for institutional, discontinued, or low-volume packs. | |
| Medicaid paysCMS SDUD · 12 mo | No recent Medicaid claims on file for this NDC — rare and low-volume NDCs are suppressed in the public data. | |
| Medicare drug plans payPart D · quarterly | No Part D plan price is available for this NDC in our data. | |
Where does this data come from?
- CMS NADAC weekly file
- CMS ASP pricing files · refreshed Sep 20, 2026
- CMS Medicaid State Drug Utilization Data · refreshed Oct 2, 2026
- CMS Part D plan pricing files · refreshed Sep 24, 2026
- VA National Acquisition Center price file
Packaging — all sizes for this product
| Package NDC | Description | Marketing start | Marketing end | Status |
|---|---|---|---|---|
| 69396-0025-05 You're viewing this Main listing | 1 TUBE in 1 BOX / 15 g in 1 TUBE | 2016-12-29 | — | Active |
| 69396-0025-15 69396-025-15 | 1 TUBE in 1 BOX / 42 g in 1 TUBE | 2020-02-11 | — | Active |
Pack size FAQ
What quantity is in this package?
What NDC number is used to bill for this package of Anti-Itch Cream Diphenhydramine hydrochloride 2%, zinc acetate 0.1% 2 g/100g; .1 g/100g Cream?
Therapeutic equivalents
| Product | Labeler | Pack | NADAC/unit | TE | Status | Price vs. this |
|---|---|---|---|---|---|---|
| good sense itch relief 2 g/100g; .1 g/100g 00113-0622-64 | L. | 1 tube | $0.058 | — | Availability likely | — |
| Banophen 2 g/100g; .1 g/100g 00904-5354-31 | Major | 1 tube | $0.058 | — | Availability likely | — |
| diphenhydramine hcl and zinc acetate 2 g/100g; .1 g/100g 45802-0358-03 | Padagis | 1 tube | $0.058 | — | Availability likely | — |
| GNP Extra Strength Anti-Itch Cream .1 g/100g; 2 g/100g 46122-0804-36 | Amerisource | 1 tube | $0.058 | — | Availability likely | — |
| leader anti itch 2 g/100g; .1 g/100g 70000-0388-01 | Cardinal | 1 tube | $0.058 | — | Availability likely | — |
| foster and thrive anti itch cream 2 g/100g; .1 g/100g 70677-1289-01 | Strategic | 1 tube | $0.058 | — | Availability likely | — |
| Anti-Itch 20 mg/g; 1 mg/g 24385-0210-03 | Amerisource | 1 tube | $0.130 | — | Discontinued | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 70677-1213-01 | STRATEGIC | 1 tube | $0.130 | — | FDA listed | — |
| Walgreens Anti Itch Cream 20 mg/g; 1 mg/g 00363-2315-28 | Walgreens | 1 tube | — | — | FDA listed | — |
| Dr. Sheffield Anti Itch Cream 20 mg/g; 1 mg/g 11527-0069-04 | Sheffield | 1 tube | — | — | FDA listed | — |
| Anti-itch 20 mg/g; 1 mg/g 11673-0895-28 | Target | 1 tube | — | — | FDA listed | — |
| Rite Aid Extra Strength Itch Stopping 1 mg/g; 20 mg/g 11822-6614-01 | Rite | 1 tube | — | — | FDA listed | — |
| signature care itch relief 2 g/100g; .1 g/100g 21130-0154-64 | Safeway | 1 tube | — | — | FDA listed | — |
| anti itch 2 g/100g; .1 g/100g 30142-0582-64 | Kroger | 1 tube | — | — | FDA listed | — |
| Shopko Anti-Itch 20 mg/g; 1 mg/g 37012-0089-02 | Shopko | 1 tube | — | — | FDA listed | — |
| itch relief 2 g/100g; .1 g/100g 37808-0622-64 | H | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 1 mg/g; 20 mg/g 41226-0888-02 | Kroger | 1 tube | — | — | FDA listed | — |
| Anti Itch 2 g/100g; .1 g/100g 41250-0622-64 | Meijer | 1 tube | — | — | FDA listed | — |
| Equate Anti Itch 2 g/100g; .1 g/100g 49035-0622-64 | Wal-Mart | 1 tube | — | — | FDA listed | — |
| Diphenhydramine Hydrochloride and Zinc Acetate 20 mg/g; 1 mg/g 51672-2089-02 | Sun | 1 tube | — | — | FDA listed | — |
| CAREALL Anti-Itch 20 mg/g; 1 mg/g 51824-0088-01 | New | 35 g | — | — | FDA listed | — |
| Extra Strength Itch Stopping 20 mg/g; 1 mg/g 52000-0071-02 | Universal | 1 tube | — | — | FDA listed | — |
| Discount Drug Mart Extra Strength Itch Stopping 20 mg/g; 1 mg/g 53943-0258-01 | Discount | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100g 55621-0007-01 | Zhejiang | 1 tube | — | — | FDA listed | — |
| ItchZap 20 mg/g; 1 mg/g 57237-0352-28 | Rising | 1 tube | — | — | FDA listed | — |
| Itch Relief 2 g/100g; .1 g/100g 59779-0708-64 | CVS | 1 tube | — | — | FDA listed | — |
| Itch Relief Cream 2 g/100g; .1 g/100g 68016-0163-01 | Pharmacy | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100gthis 69396-0025-05 | Trifecta | 1 tube | — | — | FDA listed | — |
| Itch stopping Cream 2 g/100g; .1 g/100g 69396-0150-01 | Trifecta | 1 tube | — | — | FDA listed | — |
| itch relief 1 mg/g; 20 mg/g 69452-0449-37 | Bionpharma | 1 tube | — | — | FDA listed | — |
| Family Wellness 2 g/100g; .1 g/100g 69571-0005-02 | FRONT | 1 tube | — | — | FDA listed | — |
| CVS Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69842-0321-28 | CVS | 1 tube | — | — | FDA listed | — |
| Benadryl Extra Strength Itch Stopping 20 mg/g; 1 mg/g 69968-0223-01 | Kenvue | 1 tube | — | — | FDA listed | — |
| TheraCare 2% Diphenhydramine Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0014-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Caring Mill Anti-Itch Cream 20 mg/g; 1 mg/g 71101-0055-01 | Veridian | 1 tube | — | — | FDA listed | — |
| Anti-Itch Cream 2 g/100g; .1 g/100g 83324-0039-01 | Chain | 1 tube | — | — | FDA listed | — |
| Savvy Itch Stopping 2 g/100g; .1 g/100g 83650-0102-01 | Savvy | 35.4 g | — | — | FDA listed | — |
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- FDA Orange Book · refreshed Sep 3, 2026
- CMS NADAC weekly file
Availability & generic status
We did not find an FDA-approved generic match for this exact strength, form and route.
Where does this data come from?
- FDA Orange Book · refreshed Sep 3, 2026
Inactive Ingredients / Excipients
Inactive ingredients, also called excipients, are components of the drug product other than the active ingredient. They may include fillers, dyes, coatings, preservatives, flavors, or other formulation ingredients.
💡 Tap an ingredient (hover on desktop) to see what it is and why it’s used.
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UNII 2DMT128M1S
A waxy solid derived from plant or animal sources. It acts as an emulsifier to blend oil and water components, and also thickens the medicine to give it the right texture and consistency.
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UNII 230OU9XXE4
A waxy substance made from glycerin and stearic acid that acts as an emulsifier to blend oily and watery ingredients together. It also helps thicken and stabilize the medicine's texture.
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UNII N72LMW566G
A synthetic cleansing agent derived from lauryl alcohol and ethylene oxide. It helps dissolve and mix oil and water-based ingredients in liquid medicines, acting as an emulsifier and solubilizer.
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UNII A2I8C7HI9T
Methylparaben is a preservative derived from benzoic acid that prevents growth of bacteria, fungi, and mold in medicines. It extends the product's shelf life and maintains safety during storage.
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UNII T5L8T28FGP
Mineral oil is a clear, odorless liquid derived from crude oil. It acts as a lubricant and emollient in medications, helping pills slide smoothly during manufacturing and aiding moisture retention in topical products.
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UNII 4T6H12BN9U
Petrolatum is a purified mineral oil-based jelly derived from petroleum. In medicines, it acts as an emollient, lubricant, and moisture barrier to soften skin, reduce friction, and help prevent water loss from formulations.
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UNII 6DC9Q167V3
Propylene glycol is a clear liquid derived from petroleum or vegetable sources. It acts as a solvent, humectant, and preservative in medicines, helping dissolve active ingredients and maintain product stability.
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UNII Z8IX2SC1OH
Propylparaben is a chemical preservative used to prevent bacterial and fungal growth in medicines and personal care products. It helps extend shelf life and maintain product safety during storage.
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UNII 4ELV7Z65AP
Stearic acid is a fatty acid derived from plant or animal sources. It acts as a binder and lubricant in tablets and capsules, helping them hold together and flow smoothly during manufacturing.
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UNII 2KR89I4H1Y
Stearyl alcohol is a waxy, fatty substance derived from natural oils or made synthetically. It acts as an emulsifier and thickener in medicines, helping mix ingredients together and give the product the right texture.
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UNII 059QF0KO0R
Water is a liquid solvent that dissolves and mixes ingredients together in liquid medicines, syrups, and injections. It helps distribute the active drug evenly throughout the product.
11 inactive ingredients listed in the exact product block matched to this NDC.
Label-section wording can be broader than the structured product block and may mention additional formulation ingredients.
Where does this data come from?
ingredient classCode="IACT" elements from the exact product block matched by this NDC. Label-section narrative from DailyMed / the openFDA label index is shown separately when available.- FDA label on DailyMed · label index refreshed Oct 1, 2026
- FDA openFDA NDC Directory · synced Oct 1, 2026
Inactive ingredient FAQ
Are inactive ingredients the same for every manufacturer?
Why might an inactive ingredient be missing?
Can inactive ingredients matter?
Manufacturer & labeler
Where does this data come from?
- FDA openFDA NDC Directory · synced Oct 1, 2026
- Drugs@FDA
FDA label — Drug Facts FDA SPL
🎯 Indications and Usage ▾
For the temporary relief from pain and itching associated with insect bites minor burns minor skin irritation rashes due to poison ivy, poison oak, and poison sumac dries the weeping and oozing of poison ivy, oak and sumac
⏱️ Dosage and Administration ▾
Directions Do not use more than directed Adults and children 2 years of age and older: apply to affected area not more than 3 to 4 times daily Children under 2 years of age: consult a doctor
⚠️ Warnings ▾
Warnings For External Use Only Do not use on large areas of the body or with any other product containing diphenhydramine, even one taken by mouth Ask a doctor before use on chicken pox or measles When using this product avoid contact with eyes Stop use and ask a doctor if Conditions worsen or do not improve within 7 days Symptoms persist for more than 7 days or clear up and occur again within a few days
📦 Storage and Handling ▾
Other information Store at controlled room temperature 20º-25ºC (68º-77ºF) Close cap tightly after use Questions? Call 1-888-296-9067
🧪 Active Ingredient ▾
Active Ingredient Diphenhydramine Hydrochloride 2%
Active Ingredient Zinc Acetate 0.1%
🧪 Inactive Ingredients ▾
Inactive Ingredients Aloe Vera (Aloe Barbadensis) leaf juice, Cetyl alcohol, Glyceryl monostearate, Methylparaben, Mineral Oil, Petrolatum, Polyoxyethylene lauryl ether, Propylene glycol, Propylparaben, Purified Water, Stearic acid
🎯 Purpose ▾
Purpose Topical Analgesic
Purpose Skin Protectant
📄 Stop Use and Ask a Doctor If ▾
Stop use and ask a doctor Conditions worsen or do not improve within 7 days Symptoms persist for more than 7 days or clear up and occur again within a few days
📄 Keep Out of Reach of Children ▾
Keep out of the reach of children If swallowed, get medical help or contact a Poison Control Center immediately
📄 Package Label / Principal Display Panel ▾
Packaging Globe Anti-itch Cream 1.5oz Rev10 062422 CDER
About this NDC listing & data coverage
What data is (and isn’t) available for this NDC — tap to expand
| NDC identity (package / product / labeler codes) | ✓ Available |
| Labeler | ✓ Available |
| Product & package description | ✓ Available |
| Marketing category & status | ✓ Available |
| Active ingredient / dosage form / route | ✓ Available |
| FDA label (SPL via DailyMed) | ✓ Available |
| Package photos | ✓ Available |
| Inactive ingredients (structured) | ✓ Available |
| NADAC pharmacy acquisition price (CMS) | — Not published for this NDC CMS publishes NADAC only for NDCs reported in its retail-pharmacy survey. |
| Orange Book / therapeutic-equivalence data | — Not published for this NDC Applies only to products approved under an NDA/ANDA; many listings are out of scope. |
| HCPCS J-code billing crosswalk | — Not published for this NDC Most self-administered / retail products have no J-code — that is normal. |
| Medicaid utilization (CMS SDUD) | — Not published for this NDC CMS reports utilization only for NDCs with Medicaid claims above its privacy threshold. |